SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yrr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 2yrr AMINOTRANSFERASE,
CLASS V
(Thermus
thermophilus) 		4 / 8 GLY A 138
THR A 287
GLY A 133
LEU A 168
 None
 0.74A 1aegA-2yrrA:
undetectable		 1aegA-2yrrA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 2yrr AMINOTRANSFERASE,
CLASS V
(Thermus
thermophilus) 		4 / 4 ARG A 204
ALA A 199
ALA A  55
GLU A 225
 None
 1.16A 1e7bA-2yrrA:
undetectable		 1e7bA-2yrrA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 2yrr AMINOTRANSFERASE,
CLASS V
(Thermus
thermophilus) 		4 / 8 LEU A   4
ARG A 326
GLY A 138
PHE A 342
 None
 0.92A 1fapB-2yrrA:
undetectable		 1fapB-2yrrA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2yrr AMINOTRANSFERASE,
CLASS V
(Thermus
thermophilus) 		4 / 5 GLU A 270
LEU A 343
ASP A 347
LEU A 350
 None
 1.17A 1n13B-2yrrA:
undetectable
1n13C-2yrrA:
undetectable		 1n13B-2yrrA:
14.89
1n13C-2yrrA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 2yrr AMINOTRANSFERASE,
CLASS V
(Thermus
thermophilus) 		5 / 11 ALA A 345
LEU A 306
ALA A 305
LEU A   4
VAL A 313
 None
 1.11A 2bxeB-2yrrA:
undetectable		 2bxeB-2yrrA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2yrr AMINOTRANSFERASE,
CLASS V
(Thermus
thermophilus) 		5 / 10 THR A 320
ILE A 317
GLY A 318
GLY A  83
THR A 137
 None
 1.40A 2y7wB-2yrrA:
0.6		 2y7wB-2yrrA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 2yrr AMINOTRANSFERASE,
CLASS V
(Thermus
thermophilus) 		5 / 12 GLY A   7
VAL A 248
GLY A 331
ALA A 190
ALA A 244
 None
 1.09A 3keeB-2yrrA:
undetectable		 3keeB-2yrrA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 2yrr AMINOTRANSFERASE,
CLASS V
(Thermus
thermophilus) 		5 / 12 GLY A   7
VAL A 248
GLY A 331
ALA A 190
ALA A 244
 None
 1.08A 3keeC-2yrrA:
undetectable		 3keeC-2yrrA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 2yrr AMINOTRANSFERASE,
CLASS V
(Thermus
thermophilus) 		4 / 6 ALA A  55
HIS A 223
HIS A 238
ASN A  35
 None
 1.00A 3nneG-2yrrA:
undetectable		 3nneG-2yrrA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 2yrr AMINOTRANSFERASE,
CLASS V
(Thermus
thermophilus) 		5 / 12 SER A  62
GLY A 183
LEU A 215
ASP A 216
PHE A 207
 PLP  A 500 (-2.7A)
None
None
None
None
 1.28A 3r24A-2yrrA:
2.5		 3r24A-2yrrA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2yrr AMINOTRANSFERASE,
CLASS V
(Thermus
thermophilus) 		4 / 8 PRO A 294
VAL A 291
LEU A 325
LEU A 327
 None
 0.89A 3u5kA-2yrrA:
undetectable		 3u5kA-2yrrA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 2yrr AMINOTRANSFERASE,
CLASS V
(Thermus
thermophilus) 		4 / 7 THR A 232
HIS A 238
ASN A  35
LEU A  32
 None
 1.38A 4awuA-2yrrA:
undetectable		 4awuA-2yrrA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 2yrr AMINOTRANSFERASE,
CLASS V
(Thermus
thermophilus) 		5 / 10 LEU A 350
LEU A 346
VAL A 291
LEU A 289
LEU A 268
 None
 1.03A 4po0A-2yrrA:
undetectable		 4po0A-2yrrA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 2yrr AMINOTRANSFERASE,
CLASS V
(Thermus
thermophilus) 		4 / 7 SER A  86
ARG A 326
SER A 136
GLU A 134
 None
 1.30A 4xzkA-2yrrA:
undetectable		 4xzkA-2yrrA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2yrr AMINOTRANSFERASE,
CLASS V
(Thermus
thermophilus) 		6 / 9 SER A 184
ALA A  56
ALA A  55
GLY A 193
GLY A  59
ALA A  58
 None
 1.47A 5d0xK-2yrrA:
undetectable
5d0xL-2yrrA:
undetectable		 5d0xK-2yrrA:
19.02
5d0xL-2yrrA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2yrr AMINOTRANSFERASE,
CLASS V
(Thermus
thermophilus) 		6 / 9 SER A 184
ALA A  56
ALA A  55
GLY A 193
GLY A  59
ALA A  58
 None
 1.47A 5d0xY-2yrrA:
undetectable
5d0xZ-2yrrA:
undetectable		 5d0xY-2yrrA:
19.02
5d0xZ-2yrrA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 2yrr AMINOTRANSFERASE,
CLASS V
(Thermus
thermophilus) 		5 / 11 ALA A 349
ALA A 345
VAL A 311
LEU A 346
VAL A 313
 None
 1.11A 5eb5A-2yrrA:
undetectable		 5eb5A-2yrrA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 2yrr AMINOTRANSFERASE,
CLASS V
(Thermus
thermophilus) 		5 / 12 LEU A 329
LEU A 289
PHE A 276
PHE A 342
LEU A   4
 None
 1.16A 5uanB-2yrrA:
undetectable		 5uanB-2yrrA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 2yrr AMINOTRANSFERASE,
CLASS V
(Thermus
thermophilus) 		4 / 8 ARG A 256
ALA A 260
VAL A 263
GLY A 333
 None
 0.92A 5v0vA-2yrrA:
undetectable		 5v0vA-2yrrA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_G_6ELG501_0
(PROTEIN CEREBLON)		 2yrr AMINOTRANSFERASE,
CLASS V
(Thermus
thermophilus) 		4 / 8 PHE A  46
HIS A 231
THR A 233
TRP A 224
 None
 1.37A 5yj1G-2yrrA:
undetectable
5yj1Y-2yrrA:
undetectable		 5yj1G-2yrrA:
16.93
5yj1Y-2yrrA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2yrr AMINOTRANSFERASE,
CLASS V
(Thermus
thermophilus) 		4 / 6 ARG A 211
ALA A  70
LEU A  69
ALA A  93
 None
 1.17A 6fosB-2yrrA:
undetectable		 6fosB-2yrrA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_0
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 2yrr AMINOTRANSFERASE,
CLASS V
(Thermus
thermophilus) 		5 / 12 PRO A  29
TYR A 239
HIS A 238
THR A 233
HIS A 223
 None
 1.46A 6hloA-2yrrA:
2.1		 6hloA-2yrrA:
21.66