SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ys6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Geobacillus
kaustophilus) 		5 / 12 ALA A 256
GLU A 260
LEU A 257
LEU A 109
LEU A 268
 None
 0.89A 1errB-2ys6A:
undetectable		 1errB-2ys6A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Geobacillus
kaustophilus) 		5 / 12 GLY A 362
ASN A  34
GLY A  10
ASP A 290
VAL A 377
 None
 1.29A 1ffyA-2ys6A:
undetectable		 1ffyA-2ys6A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Geobacillus
kaustophilus) 		4 / 6 VAL A  30
VAL A  25
ILE A  63
ARG A  11
 None
 1.06A 1iepA-2ys6A:
undetectable		 1iepA-2ys6A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI2_A_GA2A1_1
(THYMIDINE KINASE)		 2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Geobacillus
kaustophilus) 		5 / 11 HIS A 213
GLU A 191
ILE A 417
TYR A 231
ARG A 415
 None
 1.47A 1ki2A-2ys6A:
0.0		 1ki2A-2ys6A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Geobacillus
kaustophilus) 		5 / 12 HIS A 213
GLU A 191
ILE A 417
TYR A 231
ARG A 415
 None
 1.39A 1ki7A-2ys6A:
undetectable		 1ki7A-2ys6A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Geobacillus
kaustophilus) 		5 / 12 HIS A 213
GLU A 191
ILE A 417
TYR A 231
ARG A 415
 None
 1.44A 1ki7B-2ys6A:
undetectable		 1ki7B-2ys6A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Geobacillus
kaustophilus) 		4 / 7 VAL A  79
LEU A 268
ALA A  97
LEU A  74
 None
 0.70A 1pthA-2ys6A:
undetectable		 1pthA-2ys6A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Geobacillus
kaustophilus) 		4 / 7 VAL A  79
LEU A 268
ALA A  97
LEU A  74
 None
 0.70A 1pthB-2ys6A:
undetectable		 1pthB-2ys6A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Geobacillus
kaustophilus) 		4 / 7 ILE A  46
LEU A   4
ILE A  51
ASP A  50
 None
 0.91A 1yc2E-2ys6A:
3.0		 1yc2E-2ys6A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Geobacillus
kaustophilus) 		4 / 5 LEU A 250
PHE A 284
VAL A 199
ALA A 197
 None
 1.13A 2cizA-2ys6A:
undetectable		 2cizA-2ys6A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Geobacillus
kaustophilus) 		4 / 8 ARG A  88
PHE A  90
GLY A  91
GLY A 314
 None
 0.94A 2y6rB-2ys6A:
4.0		 2y6rB-2ys6A:
24.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Geobacillus
kaustophilus) 		8 / 8 ASP A 212
LYS A 214
TYR A 269
ASN A 285
ARG A 287
GLY A 289
PRO A 291
GLU A 292
 GLY  A 431 (-3.5A)
GLY  A 431 ( 3.6A)
GLY  A 431 (-4.8A)
GLY  A 431 (-3.6A)
GLY  A 431 (-3.0A)
GLY  A 431 (-3.4A)
GLY  A 431 ( 4.8A)
GLY  A 431 (-3.1A)
 0.02A 2ys6A-2ys6A:
70.5		 2ys6A-2ys6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Geobacillus
kaustophilus) 		4 / 7 GLY A  33
ASN A  34
ALA A  16
VAL A  40
 None
 0.79A 3a2qA-2ys6A:
undetectable		 3a2qA-2ys6A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Geobacillus
kaustophilus) 		5 / 12 ALA A 253
ALA A  96
GLY A 101
GLU A 100
THR A 117
 None
 1.14A 3c6gB-2ys6A:
undetectable		 3c6gB-2ys6A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_D_ACTD229_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Geobacillus
kaustophilus) 		4 / 4 ASP A 313
GLY A 314
LYS A 315
GLU A 316
 None
 1.49A 3hznD-2ys6A:
undetectable		 3hznD-2ys6A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Geobacillus
kaustophilus) 		4 / 5 LEU A 327
GLN A 211
HIS A 213
GLY A 413
 None
 1.13A 3pp1A-2ys6A:
undetectable		 3pp1A-2ys6A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Geobacillus
kaustophilus) 		4 / 5 PHE A 288
ALA A 307
THR A 302
LEU A 207
 None
 1.23A 3t3zC-2ys6A:
undetectable		 3t3zC-2ys6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TX2_A_BEZA251_0
(PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE)		 2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Geobacillus
kaustophilus) 		4 / 7 LYS A  18
ALA A  14
TRP A  17
ALA A 293
 None
 1.15A 3tx2A-2ys6A:
undetectable		 3tx2A-2ys6A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Geobacillus
kaustophilus) 		4 / 4 PRO A 298
LEU A 297
ILE A  15
ARG A  11
 None
 1.41A 3w1wA-2ys6A:
2.6		 3w1wA-2ys6A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Geobacillus
kaustophilus) 		5 / 12 ASP A 290
ALA A 361
ASN A  34
ILE A 412
ARG A 376
 None
 1.23A 3wenA-2ys6A:
undetectable		 3wenA-2ys6A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Geobacillus
kaustophilus) 		5 / 12 ASP A 290
ALA A 361
ASN A  34
ILE A 412
ARG A 376
 None
 1.23A 3weoA-2ys6A:
undetectable		 3weoA-2ys6A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Geobacillus
kaustophilus) 		5 / 12 HIS A 213
GLY A 271
SER A 194
GLY A 413
ASP A 212
 None
None
None
None
GLY  A 431 (-3.5A)
 1.12A 4blvB-2ys6A:
undetectable		 4blvB-2ys6A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Geobacillus
kaustophilus) 		5 / 12 GLY A  10
GLY A   9
ILE A  37
PHE A 288
ILE A  15
 None
 1.28A 4fglA-2ys6A:
undetectable
4fglB-2ys6A:
undetectable		 4fglA-2ys6A:
20.18
4fglB-2ys6A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Geobacillus
kaustophilus) 		4 / 7 ILE A  15
LEU A 304
VAL A  68
ALA A 293
 None
 0.69A 4g77A-2ys6A:
undetectable		 4g77A-2ys6A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Geobacillus
kaustophilus) 		5 / 12 GLY A 266
ILE A  99
ALA A  97
ALA A 253
MET A 196
 None
 1.21A 4kicA-2ys6A:
3.6		 4kicA-2ys6A:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Geobacillus
kaustophilus) 		5 / 11 GLY A  10
GLY A   9
ILE A  37
PHE A 288
ILE A  15
 None
 1.14A 4qoiA-2ys6A:
2.7
4qoiB-2ys6A:
3.0		 4qoiA-2ys6A:
18.70
4qoiB-2ys6A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Geobacillus
kaustophilus) 		4 / 8 GLY A 405
LEU A 406
GLU A 341
ALA A 333
 None
 0.66A 5vw5A-2ys6A:
undetectable		 5vw5A-2ys6A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
(Geobacillus
kaustophilus) 		5 / 12 LEU A 297
VAL A 296
PHE A 264
PHE A 198
VAL A 308
 None
 1.30A 6a94A-2ys6A:
undetectable		 6a94A-2ys6A:
23.13