SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ysk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 2ysk HYPOTHETICAL PROTEIN
TTHA1432
(Thermus
thermophilus) 		4 / 5 HIS A  44
GLU A  96
ALA A  38
HIS A  33
 None
 1.38A 1errA-2yskA:
undetectable
1errB-2yskA:
undetectable		 1errA-2yskA:
22.13
1errB-2yskA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 2ysk HYPOTHETICAL PROTEIN
TTHA1432
(Thermus
thermophilus) 		5 / 12 LEU A  50
VAL A 130
VAL A 114
LEU A 118
LEU A  39
 None
 1.30A 1mx1E-2yskA:
undetectable		 1mx1E-2yskA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 2ysk HYPOTHETICAL PROTEIN
TTHA1432
(Thermus
thermophilus) 		5 / 12 ILE A  23
PHE A  89
LEU A  39
VAL A  66
LEU A 118
 None
 1.14A 4g1bD-2yskA:
undetectable		 4g1bD-2yskA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2ysk HYPOTHETICAL PROTEIN
TTHA1432
(Thermus
thermophilus) 		3 / 3 PRO A  63
LEU A  62
HIS A  44
 SO4  A 146 (-4.1A)
None
None
 0.69A 4pevA-2yskA:
undetectable		 4pevA-2yskA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 2ysk HYPOTHETICAL PROTEIN
TTHA1432
(Thermus
thermophilus) 		3 / 3 ARG A  67
GLU A 126
TYR A  71
 SO4  A 146 ( 4.6A)
None
None
 0.86A 4r29D-2yskA:
undetectable		 4r29D-2yskA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ysk HYPOTHETICAL PROTEIN
TTHA1432
(Thermus
thermophilus) 		5 / 5 LEU A  37
LYS A  34
ALA A  38
LEU A  39
LEU A  27
 None
 1.45A 5vkqA-2yskA:
undetectable
5vkqD-2yskA:
undetectable		 5vkqA-2yskA:
6.69
5vkqD-2yskA:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ysk HYPOTHETICAL PROTEIN
TTHA1432
(Thermus
thermophilus) 		5 / 5 LEU A  27
LEU A  37
LYS A  34
ALA A  38
LEU A  39
 None
 1.44A 5vkqA-2yskA:
undetectable
5vkqB-2yskA:
undetectable		 5vkqA-2yskA:
6.69
5vkqB-2yskA:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ysk HYPOTHETICAL PROTEIN
TTHA1432
(Thermus
thermophilus) 		5 / 5 LEU A  27
LEU A  37
LYS A  34
ALA A  38
LEU A  39
 None
 1.44A 5vkqB-2yskA:
undetectable
5vkqC-2yskA:
undetectable		 5vkqB-2yskA:
6.69
5vkqC-2yskA:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ysk HYPOTHETICAL PROTEIN
TTHA1432
(Thermus
thermophilus) 		5 / 5 LEU A  27
LEU A  37
LYS A  34
ALA A  38
LEU A  39
 None
 1.43A 5vkqC-2yskA:
undetectable
5vkqD-2yskA:
undetectable		 5vkqC-2yskA:
6.69
5vkqD-2yskA:
6.69