SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ysz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1D4F_B_ADNB602_1 (S-ADENOSYLHOMOCYSTEI NE HYDROLASE)	2ysz	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 2 AND AMYLOID BETA A4 PROTEIN (Mus musculus)	5 / 12	HIS A 163 LEU A 164 GLY A 91 MET A 34 PHE A 87	None	1.40A	1d4fB-2yszA: undetectable	1d4fB-2yszA: 18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5I1N_G_DVAG9_0 (D-VILLIN HEADPIECE SUBDOMAIN VILLIN-1)	2ysz	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 2 AND AMYLOID BETA A4 PROTEIN (Mus musculus)	3 / 3	ALA A 40 ASN A 43 LEU A 44	None	0.36A	5i1nB-2yszA: undetectable	5i1nB-2yszA: 8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5I1O_H_DVAH9_0 (D-VILLIN HEADPIECE SUBDOMAIN VILLIN-1)	2ysz	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 2 AND AMYLOID BETA A4 PROTEIN (Mus musculus)	3 / 3	ALA A 40 ASN A 43 LEU A 44	None	0.42A	5i1oA-2yszA: undetectable	5i1oA-2yszA: 8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LF7_H_6V8H305_0 (PROTEASOME SUBUNIT BETA TYPE-3 PROTEASOME SUBUNIT BETA TYPE-7)	2ysz	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 2 AND AMYLOID BETA A4 PROTEIN (Mus musculus)	5 / 11	ALA A 40 GLY A 91 ALA A 98 THR A 96 LEU A 85	None	1.11A	5lf7H-2yszA: undetectable 5lf7I-2yszA: undetectable	5lf7H-2yszA: 22.22 5lf7I-2yszA: 16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LF7_V_6V8V303_0 (PROTEASOME SUBUNIT BETA TYPE-3 PROTEASOME SUBUNIT BETA TYPE-7)	2ysz	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 2 AND AMYLOID BETA A4 PROTEIN (Mus musculus)	5 / 11	ALA A 40 GLY A 91 ALA A 98 THR A 96 LEU A 85	None	1.10A	5lf7V-2yszA: undetectable 5lf7W-2yszA: undetectable	5lf7V-2yszA: 22.22 5lf7W-2yszA: 16.11

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1D4F_B_ADNB602_1","S-ADENOSYLHOMOCYSTEINE HYDROLASE","2ysz","AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 2 AND AMYLOID BETA A4 PROTEIN","Mus musculus",5,"HIS A 163;LEU A 164;GLY A  91;MET A  34;PHE A  87","None","1.40A","1d4fB-2yszA:undetectable","1d4fB-2yszA:18.96"],["5I1N_G_DVAG9_0","D-VILLIN HEADPIECE SUBDOMAIN;VILLIN-1","2ysz","AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 2 AND AMYLOID BETA A4 PROTEIN","Mus musculus",3,"ALA A  40;ASN A  43;LEU A  44","None","0.36A","5i1nB-2yszA:undetectable","5i1nB-2yszA:8.11"],["5I1O_H_DVAH9_0","D-VILLIN HEADPIECE SUBDOMAIN;VILLIN-1","2ysz","AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 2 AND AMYLOID BETA A4 PROTEIN","Mus musculus",3,"ALA A  40;ASN A  43;LEU A  44","None","0.42A","5i1oA-2yszA:undetectable","5i1oA-2yszA:8.11"],["5LF7_H_6V8H305_0","PROTEASOME SUBUNIT BETA TYPE-3;PROTEASOME SUBUNIT BETA TYPE-7","2ysz","AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 2 AND AMYLOID BETA A4 PROTEIN","Mus musculus",5,"ALA A  40;GLY A  91;ALA A  98;THR A  96;LEU A  85","None","1.11A","5lf7H-2yszA:undetectable;5lf7I-2yszA:undetectable","5lf7H-2yszA:22.22;5lf7I-2yszA:16.11"],["5LF7_V_6V8V303_0","PROTEASOME SUBUNIT BETA TYPE-3;PROTEASOME SUBUNIT BETA TYPE-7","2ysz","AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 2 AND AMYLOID BETA A4 PROTEIN","Mus musculus",5,"ALA A  40;GLY A  91;ALA A  98;THR A  96;LEU A  85","None","1.10A","5lf7V-2yszA:undetectable;5lf7W-2yszA:undetectable","5lf7V-2yszA:22.22;5lf7W-2yszA:16.11"]]