SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yt0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)
2yt0 AMYLOID BETA A4
PROTEIN AND AMYLOID
BETA A4 PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 2

(Mus
musculus)
5 / 12 HIS A  17
LEU A  18
GLY A 137
MET A  80
PHE A 133
None
1.37A 1d4fB-2yt0A:
undetectable
1d4fB-2yt0A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)
2yt0 AMYLOID BETA A4
PROTEIN AND AMYLOID
BETA A4 PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 2

(Mus
musculus)
3 / 3 ARG A  76
ASP A  81
ASP A  75
None
0.64A 3jb2A-2yt0A:
undetectable
3jb2A-2yt0A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)
2yt0 AMYLOID BETA A4
PROTEIN AND AMYLOID
BETA A4 PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 2

(Mus
musculus)
3 / 3 ARG A  76
ASP A  81
ASP A  75
None
0.71A 3jb3A-2yt0A:
undetectable
3jb3A-2yt0A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)
2yt0 AMYLOID BETA A4
PROTEIN AND AMYLOID
BETA A4 PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 2

(Mus
musculus)
3 / 3 ARG A 127
VAL A  61
THR A  58
None
0.85A 3pwrA-2yt0A:
undetectable
3pwrA-2yt0A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)
2yt0 AMYLOID BETA A4
PROTEIN AND AMYLOID
BETA A4 PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 2

(Mus
musculus)
3 / 3 HIS A  17
GLU A  14
ASN A 167
None
0.97A 4bupB-2yt0A:
undetectable
4bupB-2yt0A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
2yt0 AMYLOID BETA A4
PROTEIN AND AMYLOID
BETA A4 PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 2

(Mus
musculus)
5 / 11 PHE A 145
PHE A 143
LEU A  83
VAL A  74
THR A 149
None
1.42A 4eilA-2yt0A:
undetectable
4eilA-2yt0A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
2yt0 AMYLOID BETA A4
PROTEIN AND AMYLOID
BETA A4 PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 2

(Mus
musculus)
5 / 10 PHE A 145
PHE A 143
LEU A  83
VAL A  74
THR A 149
None
1.46A 4eilB-2yt0A:
undetectable
4eilB-2yt0A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
2yt0 AMYLOID BETA A4
PROTEIN AND AMYLOID
BETA A4 PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 2

(Mus
musculus)
5 / 12 PHE A 145
PHE A 143
LEU A  83
VAL A  74
THR A 149
None
1.47A 4kyaD-2yt0A:
undetectable
4kyaD-2yt0A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)
2yt0 AMYLOID BETA A4
PROTEIN AND AMYLOID
BETA A4 PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 2

(Mus
musculus)
4 / 4 VAL A 172
ALA A 171
ASN A 167
GLN A  62
None
1.32A 4zgfA-2yt0A:
undetectable
4zgfA-2yt0A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)
2yt0 AMYLOID BETA A4
PROTEIN AND AMYLOID
BETA A4 PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 2

(Mus
musculus)
4 / 5 ARG A 129
THR A 110
ALA A 109
ASP A 108
None
1.41A 5mfxA-2yt0A:
undetectable
5mfxA-2yt0A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_1
(-)
2yt0 AMYLOID BETA A4
PROTEIN AND AMYLOID
BETA A4 PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 2

(Mus
musculus)
5 / 12 HIS A  17
LEU A  18
GLY A 137
MET A  80
PHE A 133
None
1.29A 6f3mA-2yt0A:
undetectable
6f3mA-2yt0A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_C_ADNC502_1
(-)
2yt0 AMYLOID BETA A4
PROTEIN AND AMYLOID
BETA A4 PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 2

(Mus
musculus)
5 / 12 HIS A  17
LEU A  18
GLY A 137
MET A  80
PHE A 133
None
1.29A 6f3mC-2yt0A:
undetectable
6f3mC-2yt0A:
16.07