SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yt2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 2yt2 FIBROBLAST GROWTH
FACTOR RECEPTOR
SUBSTRATE 3 AND ALK
TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		4 / 8 ASN A  25
GLY A 134
THR A  82
GLY A  85
 None
 0.82A 1jr1B-2yt2A:
undetectable		 1jr1B-2yt2A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2yt2 FIBROBLAST GROWTH
FACTOR RECEPTOR
SUBSTRATE 3 AND ALK
TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		4 / 7 LEU A 135
PHE A  89
LEU A  49
PHE A  74
 None
 0.72A 1wrlE-2yt2A:
undetectable
1wrlF-2yt2A:
undetectable		 1wrlE-2yt2A:
16.45
1wrlF-2yt2A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5V_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 2yt2 FIBROBLAST GROWTH
FACTOR RECEPTOR
SUBSTRATE 3 AND ALK
TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		4 / 7 ARG A 137
VAL A  55
TRP A  57
PHE A  87
 None
 1.44A 3n5vA-2yt2A:
undetectable
3n5vB-2yt2A:
undetectable		 3n5vA-2yt2A:
17.26
3n5vB-2yt2A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 2yt2 FIBROBLAST GROWTH
FACTOR RECEPTOR
SUBSTRATE 3 AND ALK
TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		3 / 3 GLN A 102
PHE A  98
TYR A  65
 None
 0.89A 3ucjB-2yt2A:
undetectable		 3ucjB-2yt2A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 2yt2 FIBROBLAST GROWTH
FACTOR RECEPTOR
SUBSTRATE 3 AND ALK
TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		3 / 3 GLN A 102
PHE A  98
TYR A  65
 None
 0.92A 3ucjA-2yt2A:
undetectable		 3ucjA-2yt2A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNV_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2yt2 FIBROBLAST GROWTH
FACTOR RECEPTOR
SUBSTRATE 3 AND ALK
TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		4 / 6 ARG A 137
VAL A  55
TRP A  57
PHE A  87
 None
 1.41A 5unvA-2yt2A:
undetectable
5unvB-2yt2A:
undetectable		 5unvA-2yt2A:
17.26
5unvB-2yt2A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUJ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2yt2 FIBROBLAST GROWTH
FACTOR RECEPTOR
SUBSTRATE 3 AND ALK
TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		4 / 7 ARG A 137
VAL A  55
TRP A  57
PHE A  87
 None
 1.44A 5vujA-2yt2A:
undetectable
5vujB-2yt2A:
undetectable		 5vujA-2yt2A:
17.26
5vujB-2yt2A:
17.26