SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yt4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WV2_A_TPFA1_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2yt4 PROTEIN DGCR8
(Homo
sapiens) 		5 / 9 PHE A 532
ALA A 544
ALA A 568
THR A 572
LEU A 516
 None
 1.49A 2wv2A-2yt4A:
undetectable		 2wv2A-2yt4A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2yt4 PROTEIN DGCR8
(Homo
sapiens) 		3 / 3 ASP A 579
VAL A 504
ASN A 599
 None
 0.77A 4lmnA-2yt4A:
undetectable		 4lmnA-2yt4A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2yt4 PROTEIN DGCR8
(Homo
sapiens) 		4 / 6 LEU A 516
ILE A 515
LEU A 573
GLU A 574
 None
 0.95A 4w5nA-2yt4A:
2.2		 4w5nA-2yt4A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 2yt4 PROTEIN DGCR8
(Homo
sapiens) 		3 / 3 TYR A 530
HIS A 517
MET A 520
 None
 1.15A 6af6A-2yt4A:
undetectable		 6af6A-2yt4A:
22.67