SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yu1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 2yu1 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1A
(Homo
sapiens) 		4 / 6 HIS A 284
ILE A 234
ALA A  51
VAL A 262
 FE2  A 600 ( 3.4A)
None
None
None
 1.05A 1hk1A-2yu1A:
undetectable		 1hk1A-2yu1A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 2yu1 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1A
(Homo
sapiens) 		4 / 6 LEU A 496
LEU A 499
SER A 502
THR A 454
 None
 1.07A 1ictB-2yu1A:
undetectable		 1ictB-2yu1A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 2yu1 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1A
(Homo
sapiens) 		4 / 6 LEU A  76
LEU A  72
PRO A 160
VAL A 163
 None
 1.07A 2dqyC-2yu1A:
undetectable		 2dqyC-2yu1A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2yu1 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1A
(Homo
sapiens) 		5 / 12 PHE A 215
VAL A 220
ALA A 285
PHE A 211
TYR A 244
 None
 1.32A 2g72A-2yu1A:
undetectable		 2g72A-2yu1A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 2yu1 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1A
(Homo
sapiens) 		4 / 5 ILE A 278
PRO A  75
PHE A  53
ILE A 283
 None
 0.97A 2hjhA-2yu1A:
undetectable		 2hjhA-2yu1A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 2yu1 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1A
(Homo
sapiens) 		4 / 6 LYS A 352
GLN A 355
GLY A 481
LEU A 177
 None
 1.03A 3bjwE-2yu1A:
undetectable		 3bjwE-2yu1A:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 2yu1 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1A
(Homo
sapiens) 		4 / 8 HIS A 301
ILE A 305
TRP A 168
ARG A  73
 None
 1.43A 3ccfB-2yu1A:
undetectable		 3ccfB-2yu1A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 2yu1 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1A
(Homo
sapiens) 		6 / 10 LEU A 201
THR A 209
HIS A 212
ASP A 214
ILE A 278
HIS A 284
 None
AKG  A 701 (-3.1A)
AKG  A 701 ( 3.5A)
FE2  A 600 ( 2.1A)
None
FE2  A 600 ( 3.4A)
 0.90A 3kcxA-2yu1A:
15.9		 3kcxA-2yu1A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 2yu1 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1A
(Homo
sapiens) 		6 / 10 THR A 209
HIS A 212
ASP A 214
LYS A 229
ILE A 278
HIS A 284
 AKG  A 701 (-3.1A)
AKG  A 701 ( 3.5A)
FE2  A 600 ( 2.1A)
AKG  A 701 (-2.9A)
None
FE2  A 600 ( 3.4A)
 0.95A 3kcxA-2yu1A:
15.9		 3kcxA-2yu1A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2yu1 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1A
(Homo
sapiens) 		4 / 8 VAL A 230
TYR A 274
VAL A 286
ILE A 268
 None
None
AKG  A 701 (-4.2A)
None
 1.15A 4aftD-2yu1A:
undetectable
4aftE-2yu1A:
undetectable		 4aftD-2yu1A:
18.81
4aftE-2yu1A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2yu1 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1A
(Homo
sapiens) 		3 / 3 LEU A 471
PRO A 472
ARG A 325
 None
 0.71A 4klrB-2yu1A:
undetectable		 4klrB-2yu1A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 2yu1 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1A
(Homo
sapiens) 		5 / 11 GLY A 273
ILE A 268
THR A 288
PRO A 289
THR A 290
 None
 1.06A 4l1aA-2yu1A:
undetectable		 4l1aA-2yu1A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2yu1 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1A
(Homo
sapiens) 		5 / 12 ASP A 260
SER A 252
GLY A 259
PHE A  38
GLY A 254
 None
 1.04A 4pevB-2yu1A:
undetectable		 4pevB-2yu1A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2yu1 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1A
(Homo
sapiens) 		5 / 11 LEU A 453
GLU A 459
LEU A 461
LEU A 496
LEU A 495
 None
 1.00A 4wg0C-2yu1A:
undetectable
4wg0D-2yu1A:
undetectable
4wg0E-2yu1A:
undetectable		 4wg0C-2yu1A:
2.86
4wg0D-2yu1A:
2.86
4wg0E-2yu1A:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2yu1 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1A
(Homo
sapiens) 		5 / 11 LEU A 453
GLU A 459
LEU A 461
LEU A 496
LEU A 495
 None
 0.99A 4wg0E-2yu1A:
undetectable
4wg0F-2yu1A:
undetectable
4wg0G-2yu1A:
undetectable		 4wg0E-2yu1A:
2.86
4wg0F-2yu1A:
2.86
4wg0G-2yu1A:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yu1 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1A
(Homo
sapiens) 		4 / 4 GLN A 308
THR A 218
GLU A 315
LEU A 241
 None
 1.45A 5m66A-2yu1A:
undetectable		 5m66A-2yu1A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2yu1 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1A
(Homo
sapiens) 		4 / 6 LEU A 337
VAL A 341
THR A 345
GLU A 459
 None
 0.73A 5tudD-2yu1A:
undetectable		 5tudD-2yu1A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2yu1 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1A
(Homo
sapiens) 		4 / 8 VAL A 157
HIS A 225
PRO A 160
GLY A  85
 None
 0.93A 5w3jB-2yu1A:
undetectable		 5w3jB-2yu1A:
22.06