SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yu6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 2yu6 YTH
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 9 LEU A  40
SER A  35
ILE A  72
ILE A  23
GLY A  81
 None
 1.18A 3cv9A-2yu6A:
undetectable		 3cv9A-2yu6A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP6_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2yu6 YTH
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 PHE A  62
VAL A  91
ILE A  12
MET A  13
VAL A 117
 None
 1.46A 3sp6A-2yu6A:
undetectable		 3sp6A-2yu6A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2yu6 YTH
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 8 GLU A 125
TYR A  10
GLY A   7
ARG A   9
 None
 1.05A 4fgzA-2yu6A:
undetectable
4fgzB-2yu6A:
undetectable		 4fgzA-2yu6A:
17.53
4fgzB-2yu6A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yu6 YTH
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 5 GLU A  71
GLU A  37
THR A  32
LEU A  52
 None
 1.23A 5hm8A-2yu6A:
undetectable		 5hm8A-2yu6A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yu6 YTH
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 5 GLU A  71
GLU A  37
THR A  32
LEU A  52
 None
 1.23A 5hm8B-2yu6A:
undetectable		 5hm8B-2yu6A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yu6 YTH
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 5 GLU A  71
GLU A  37
THR A  32
LEU A  52
 None
 1.23A 5hm8C-2yu6A:
undetectable		 5hm8C-2yu6A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yu6 YTH
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 5 GLU A  71
GLU A  37
THR A  32
LEU A  52
 None
 1.23A 5hm8D-2yu6A:
undetectable		 5hm8D-2yu6A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yu6 YTH
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 5 GLU A  71
GLU A  37
THR A  32
LEU A  52
 None
 1.23A 5hm8E-2yu6A:
undetectable		 5hm8E-2yu6A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yu6 YTH
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 5 GLU A  71
GLU A  37
THR A  32
LEU A  52
 None
 1.23A 5hm8F-2yu6A:
undetectable		 5hm8F-2yu6A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yu6 YTH
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 5 GLU A  71
GLU A  37
THR A  32
LEU A  52
 None
 1.23A 5hm8H-2yu6A:
undetectable		 5hm8H-2yu6A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yu6 YTH
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 5 LEU A  40
PHE A  44
LEU A  52
PHE A  54
 None
 1.10A 5iy5P-2yu6A:
undetectable
5iy5W-2yu6A:
undetectable		 5iy5P-2yu6A:
18.70
5iy5W-2yu6A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2yu6 YTH
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 7 ASN A  20
GLN A  26
ILE A  23
GLY A  28
 None
 0.97A 5nzyA-2yu6A:
undetectable		 5nzyA-2yu6A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yu6 YTH
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 6 LEU A  40
PHE A  44
LEU A  52
PHE A  54
 None
 1.14A 5w97C-2yu6A:
undetectable
5w97J-2yu6A:
undetectable		 5w97C-2yu6A:
18.56
5w97J-2yu6A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yu6 YTH
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 5 LEU A  40
PHE A  44
LEU A  52
PHE A  54
 None
 1.21A 5x1fC-2yu6A:
undetectable
5x1fJ-2yu6A:
undetectable		 5x1fC-2yu6A:
18.56
5x1fJ-2yu6A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2yu6 YTH
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 5 LEU A  40
PHE A  44
LEU A  52
PHE A  54
 None
 1.09A 5xdxC-2yu6A:
undetectable
5xdxJ-2yu6A:
undetectable		 5xdxC-2yu6A:
18.63
5xdxJ-2yu6A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2yu6 YTH
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 5 LEU A  40
PHE A  44
LEU A  52
PHE A  54
 None
 1.09A 5xdxP-2yu6A:
undetectable
5xdxW-2yu6A:
undetectable		 5xdxP-2yu6A:
18.63
5xdxW-2yu6A:
18.10