SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yug'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GM7_B_PNNB1577_0 (PENICILLIN G ACYLASE ALPHA SUBUNIT PENICILLIN G ACYLASE BETA SUBUNIT)	2yug	PROTEIN FRG1 (Mus musculus)	4 / 8	PHE A 109 ALA A 115 PHE A 123 ILE A 145	None	1.10A	1gm7A-2yugA: undetectable 1gm7B-2yugA: undetectable	1gm7A-2yugA: 22.22 1gm7B-2yugA: 13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CKZ_A_ZMRA469_2 (NEURAMINIDASE)	2yug	PROTEIN FRG1 (Mus musculus)	4 / 6	ARG A 73 TRP A 105 ILE A 86 SER A 88	None	1.37A	3ckzA-2yugA: undetectable	3ckzA-2yugA: 17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NUN_A_Z80A201_1 (BETA-LACTOGLOBULIN)	2yug	PROTEIN FRG1 (Mus musculus)	5 / 9	ALA A 118 ILE A 37 ILE A 29 ILE A 145 ALA A 134	None	0.91A	5nunA-2yugA: undetectable	5nunA-2yugA: 20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OM3_B_DXTB501_1 (ALPHA-1-ANTICHYMOTRY PSIN)	2yug	PROTEIN FRG1 (Mus musculus)	4 / 6	LEU A 84 SER A 78 PHE A 64 HIS A 38	None	1.22A	5om3A-2yugA: undetectable 5om3B-2yugA: undetectable	5om3A-2yugA: 18.06 5om3B-2yugA: 18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VLM_G_CVIG301_0 (REGULATORY PROTEIN TETR)	2yug	PROTEIN FRG1 (Mus musculus)	5 / 12	ALA A 66 LEU A 116 ILE A 145 VAL A 17 PHE A 109	None	1.16A	5vlmG-2yugA: undetectable	5vlmG-2yugA: 22.83

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1GM7_B_PNNB1577_0","PENICILLIN G ACYLASE ALPHA SUBUNIT;PENICILLIN G ACYLASE BETA SUBUNIT","2yug","PROTEIN FRG1","Mus musculus",4,"PHE A 109;ALA A 115;PHE A 123;ILE A 145","None","1.10A","1gm7A-2yugA:undetectable;1gm7B-2yugA:undetectable","1gm7A-2yugA:22.22;1gm7B-2yugA:13.63"],["3CKZ_A_ZMRA469_2","NEURAMINIDASE","2yug","PROTEIN FRG1","Mus musculus",4,"ARG A  73;TRP A 105;ILE A  86;SER A  88","None","1.37A","3ckzA-2yugA:undetectable","3ckzA-2yugA:17.45"],["5NUN_A_Z80A201_1","BETA-LACTOGLOBULIN","2yug","PROTEIN FRG1","Mus musculus",5,"ALA A 118;ILE A  37;ILE A  29;ILE A 145;ALA A 134","None","0.91A","5nunA-2yugA:undetectable","5nunA-2yugA:20.26"],["5OM3_B_DXTB501_1","ALPHA-1-ANTICHYMOTRYPSIN;ALPHA-1-ANTICHYMOTRYPSIN","2yug","PROTEIN FRG1","Mus musculus",4,"LEU A  84;SER A  78;PHE A  64;HIS A  38","None","1.22A","5om3A-2yugA:undetectable;5om3B-2yugA:undetectable","5om3A-2yugA:18.06;5om3B-2yugA:18.52"],["5VLM_G_CVIG301_0","REGULATORY PROTEIN TETR","2yug","PROTEIN FRG1","Mus musculus",5,"ALA A  66;LEU A 116;ILE A 145;VAL A  17;PHE A 109","None","1.16A","5vlmG-2yugA:undetectable","5vlmG-2yugA:22.83"]]