SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yuh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2yuh TUBULIN-SPECIFIC
CHAPERONE C
(Homo
sapiens) 		4 / 6 ASP A  78
ALA A  57
THR A  96
THR A  93
 None
 1.44A 4z4iA-2yuhA:
undetectable		 4z4iA-2yuhA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 2yuh TUBULIN-SPECIFIC
CHAPERONE C
(Homo
sapiens) 		3 / 3 ARG A  53
THR A  51
ASP A  32
 None
 0.97A 5g5gA-2yuhA:
undetectable
5g5gB-2yuhA:
undetectable		 5g5gA-2yuhA:
21.07
5g5gB-2yuhA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2yuh TUBULIN-SPECIFIC
CHAPERONE C
(Homo
sapiens) 		3 / 3 LYS A  61
LEU A  63
ARG A  44
 None
 0.83A 5yw0A-2yuhA:
undetectable		 5yw0A-2yuhA:
19.20