SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yut'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE
(Thermus
thermophilus) 		4 / 7 THR A   6
SER A  28
HIS A  72
LEU A 145
 None
 1.12A 1ibgL-2yutA:
undetectable		 1ibgL-2yutA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 9 GLY A  10
ARG A  31
ALA A  34
LEU A  35
GLY A  29
 NAP  A 500 (-3.2A)
NAP  A 500 (-4.8A)
None
None
NAP  A 500 ( 4.1A)
 1.08A 1jb0A-2yutA:
undetectable		 1jb0A-2yutA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE
(Thermus
thermophilus) 		4 / 6 LEU A 193
ALA A  15
LEU A  12
ALA A  73
 None
None
NAP  A 500 (-4.0A)
NAP  A 500 (-4.1A)
 0.91A 2vcvB-2yutA:
undetectable		 2vcvB-2yutA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE
(Thermus
thermophilus) 		4 / 7 LEU A 193
ALA A  15
LEU A  12
ALA A  73
 None
None
NAP  A 500 (-4.0A)
NAP  A 500 (-4.1A)
 0.99A 2vcvG-2yutA:
undetectable		 2vcvG-2yutA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 9 LEU A 164
ALA A  15
LEU A  12
ALA A  73
PHE A 119
 NAP  A 500 ( 4.8A)
None
NAP  A 500 (-4.0A)
NAP  A 500 (-4.1A)
NAP  A 500 ( 4.4A)
 1.23A 2vcvI-2yutA:
undetectable		 2vcvI-2yutA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 9 LEU A 193
ALA A  15
LEU A  12
ALA A  73
PHE A 119
 None
None
NAP  A 500 (-4.0A)
NAP  A 500 (-4.1A)
NAP  A 500 ( 4.4A)
 1.00A 2vcvI-2yutA:
undetectable		 2vcvI-2yutA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE
(Thermus
thermophilus) 		4 / 6 LEU A 193
ALA A  15
LEU A  12
ALA A  73
 None
None
NAP  A 500 (-4.0A)
NAP  A 500 (-4.1A)
 0.94A 2vcvK-2yutA:
undetectable		 2vcvK-2yutA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE
(Thermus
thermophilus) 		4 / 8 LEU A 193
ALA A  15
LEU A  12
ALA A  73
 None
None
NAP  A 500 (-4.0A)
NAP  A 500 (-4.1A)
 0.84A 2vcvP-2yutA:
undetectable		 2vcvP-2yutA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE
(Thermus
thermophilus) 		4 / 7 LEU A  60
LEU A 141
LEU A  70
LEU A 171
 None
None
None
NAP  A 500 (-3.5A)
 0.92A 3g8iA-2yutA:
undetectable		 3g8iA-2yutA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE
(Thermus
thermophilus) 		3 / 3 LEU A  26
LEU A   4
ARG A 109
 None
 0.63A 3hcnB-2yutA:
2.2		 3hcnB-2yutA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 GLY A   7
GLY A  10
GLY A  14
ARG A  30
ASP A  50
 NAP  A 500 (-3.1A)
NAP  A 500 (-3.2A)
None
NAP  A 500 (-3.5A)
NAP  A 500 (-3.7A)
 0.82A 3ihtA-2yutA:
5.6		 3ihtA-2yutA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE
(Thermus
thermophilus) 		4 / 5 VAL A 117
LEU A  70
ILE A   5
ALA A  73
 None
None
None
NAP  A 500 (-4.1A)
 0.99A 3n8yB-2yutA:
undetectable		 3n8yB-2yutA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_A_PQNA847_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 9 GLY A  10
ARG A  31
ALA A  34
LEU A  35
GLY A  29
 NAP  A 500 (-3.2A)
NAP  A 500 (-4.8A)
None
None
NAP  A 500 ( 4.1A)
 1.08A 3pcqA-2yutA:
undetectable		 3pcqA-2yutA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S68_A_SAMA228_1
(CATECHOL
O-METHYLTRANSFERASE)		 2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 VAL A 117
TYR A 144
ALA A 136
PHE A 119
HIS A  97
 None
None
None
NAP  A 500 ( 4.4A)
NAP  A 500 (-4.6A)
 1.42A 3s68A-2yutA:
7.4		 3s68A-2yutA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  25
LEU A  69
GLY A  14
LEU A  12
PHE A 119
 None
None
None
NAP  A 500 (-4.0A)
NAP  A 500 ( 4.4A)
 1.24A 3tbgC-2yutA:
undetectable		 3tbgC-2yutA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 GLY A  11
GLY A 170
ARG A  31
ALA A 168
ALA A  15
 NAP  A 500 (-3.8A)
NAP  A 500 ( 4.4A)
NAP  A 500 (-4.8A)
None
None
 1.21A 4kicA-2yutA:
5.8		 4kicA-2yutA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 11 GLY A  10
ARG A  31
ALA A  34
LEU A  35
GLY A  29
 NAP  A 500 (-3.2A)
NAP  A 500 (-4.8A)
None
None
NAP  A 500 ( 4.1A)
 1.08A 4kt0A-2yutA:
undetectable
4kt0J-2yutA:
undetectable		 4kt0A-2yutA:
14.38
4kt0J-2yutA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 10 PRO A 123
VAL A 126
ALA A 135
TYR A 134
GLY A 139
 None
 1.32A 4mmdA-2yutA:
undetectable		 4mmdA-2yutA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE
(Thermus
thermophilus) 		3 / 3 GLY A 177
PRO A 178
ALA A 166
 None
None
NAP  A 500 (-4.3A)
 0.52A 4qn9B-2yutA:
2.4		 4qn9B-2yutA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 GLY A  14
ILE A   5
ALA A  73
PHE A 119
VAL A  71
 None
None
NAP  A 500 (-4.1A)
NAP  A 500 ( 4.4A)
None
 1.14A 4u8vB-2yutA:
undetectable		 4u8vB-2yutA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 GLY A  14
ILE A   5
ALA A  73
PHE A 119
VAL A  71
 None
None
NAP  A 500 (-4.1A)
NAP  A 500 ( 4.4A)
None
 1.10A 4u8yB-2yutA:
undetectable		 4u8yB-2yutA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 11 LEU A 171
GLY A 120
LEU A 141
PHE A 119
ALA A  73
 NAP  A 500 (-3.5A)
None
None
NAP  A 500 ( 4.4A)
NAP  A 500 (-4.1A)
 1.27A 4wnuC-2yutA:
undetectable		 4wnuC-2yutA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 8 ALA A 121
PRO A 123
VAL A 126
GLY A 120
GLY A 139
 None
 1.11A 4zjzB-2yutA:
3.4		 4zjzB-2yutA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  69
LEU A  51
LEU A  60
ALA A   8
LEU A  35
 None
NAP  A 500 (-4.0A)
None
None
None
 1.11A 5iepA-2yutA:
undetectable		 5iepA-2yutA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 9 GLY A  10
ARG A  31
ALA A  34
LEU A  35
GLY A  29
 NAP  A 500 (-3.2A)
NAP  A 500 (-4.8A)
None
None
NAP  A 500 ( 4.1A)
 1.09A 5l8rA-2yutA:
undetectable		 5l8rA-2yutA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 10 GLY A  10
ARG A  31
ALA A  34
LEU A  35
GLY A  29
 NAP  A 500 (-3.2A)
NAP  A 500 (-4.8A)
None
None
NAP  A 500 ( 4.1A)
 1.08A 6hqbA-2yutA:
undetectable
6hqbJ-2yutA:
undetectable		 6hqbA-2yutA:
16.15
6hqbJ-2yutA:
11.50