SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yv1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2yv1 SUCCINYL-COA LIGASE
[ADP-FORMING]
SUBUNIT ALPHA
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A 131
THR A 129
ILE A 125
GLY A 160
THR A 163
 None
 1.15A 1c9sN-2yv1A:
undetectable
1c9sO-2yv1A:
undetectable		 1c9sN-2yv1A:
13.90
1c9sO-2yv1A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2yv1 SUCCINYL-COA LIGASE
[ADP-FORMING]
SUBUNIT ALPHA
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A 131
THR A 129
ILE A 125
GLY A 160
THR A 163
 None
 1.13A 1gtfR-2yv1A:
undetectable
1gtfS-2yv1A:
undetectable		 1gtfR-2yv1A:
13.90
1gtfS-2yv1A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2yv1 SUCCINYL-COA LIGASE
[ADP-FORMING]
SUBUNIT ALPHA
(Methanocaldococc
us
jannaschii) 		5 / 11 GLY A 131
THR A 129
ILE A 125
GLY A 160
THR A 163
 None
 1.15A 1gtfS-2yv1A:
undetectable
1gtfT-2yv1A:
undetectable		 1gtfS-2yv1A:
13.90
1gtfT-2yv1A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2yv1 SUCCINYL-COA LIGASE
[ADP-FORMING]
SUBUNIT ALPHA
(Methanocaldococc
us
jannaschii) 		5 / 11 GLY A 131
THR A 129
ILE A 125
GLY A 160
THR A 163
 None
 1.13A 1utdS-2yv1A:
undetectable
1utdT-2yv1A:
undetectable		 1utdS-2yv1A:
13.90
1utdT-2yv1A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2yv1 SUCCINYL-COA LIGASE
[ADP-FORMING]
SUBUNIT ALPHA
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A 131
THR A 129
ILE A 125
GLY A 160
THR A 163
 None
 1.15A 1utdU-2yv1A:
undetectable
1utdV-2yv1A:
undetectable		 1utdU-2yv1A:
13.90
1utdV-2yv1A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2yv1 SUCCINYL-COA LIGASE
[ADP-FORMING]
SUBUNIT ALPHA
(Methanocaldococc
us
jannaschii) 		5 / 11 GLY A 160
THR A 163
GLY A 131
THR A 129
ILE A 125
 None
 1.14A 1utdL-2yv1A:
undetectable
1utdV-2yv1A:
undetectable		 1utdL-2yv1A:
13.90
1utdV-2yv1A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2yv1 SUCCINYL-COA LIGASE
[ADP-FORMING]
SUBUNIT ALPHA
(Methanocaldococc
us
jannaschii) 		4 / 6 GLY A 185
TYR A 193
ASP A 186
ASN A 128
 None
 1.26A 2g72A-2yv1A:
4.0		 2g72A-2yv1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 2yv1 SUCCINYL-COA LIGASE
[ADP-FORMING]
SUBUNIT ALPHA
(Methanocaldococc
us
jannaschii) 		5 / 12 PHE A 113
PHE A  77
ILE A  40
ALA A  16
ALA A  90
 None
 1.11A 2j0dA-2yv1A:
undetectable		 2j0dA-2yv1A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2yv1 SUCCINYL-COA LIGASE
[ADP-FORMING]
SUBUNIT ALPHA
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 182
GLY A 190
GLY A 126
ILE A 188
ASP A 186
 None
 0.92A 2nxeA-2yv1A:
6.7		 2nxeA-2yv1A:
26.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2yv1 SUCCINYL-COA LIGASE
[ADP-FORMING]
SUBUNIT ALPHA
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 182
GLY A 190
GLY A 126
ILE A 188
ASP A 186
 None
 0.97A 2nxeB-2yv1A:
6.4		 2nxeB-2yv1A:
26.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 2yv1 SUCCINYL-COA LIGASE
[ADP-FORMING]
SUBUNIT ALPHA
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A 158
SER A 159
TYR A 193
 None
 0.85A 2q2hA-2yv1A:
undetectable
2q2hB-2yv1A:
undetectable		 2q2hA-2yv1A:
21.85
2q2hB-2yv1A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2yv1 SUCCINYL-COA LIGASE
[ADP-FORMING]
SUBUNIT ALPHA
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 182
GLY A 190
GLY A 126
ILE A 188
ASP A 186
 None
 1.02A 2zbpA-2yv1A:
7.0		 2zbpA-2yv1A:
26.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 2yv1 SUCCINYL-COA LIGASE
[ADP-FORMING]
SUBUNIT ALPHA
(Methanocaldococc
us
jannaschii) 		4 / 6 GLY A 184
ILE A 183
ILE A 125
ASP A 186
 None
 0.96A 3a7eA-2yv1A:
5.1		 3a7eA-2yv1A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 2yv1 SUCCINYL-COA LIGASE
[ADP-FORMING]
SUBUNIT ALPHA
(Methanocaldococc
us
jannaschii) 		5 / 11 THR A  30
VAL A  99
GLY A 141
THR A  38
ILE A  40
 None
 1.26A 3bf1C-2yv1A:
undetectable
3bf1D-2yv1A:
2.0		 3bf1C-2yv1A:
24.60
3bf1D-2yv1A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2yv1 SUCCINYL-COA LIGASE
[ADP-FORMING]
SUBUNIT ALPHA
(Methanocaldococc
us
jannaschii) 		4 / 5 PRO A 144
VAL A 147
THR A 206
GLY A 154
 None
 1.13A 3elzB-2yv1A:
undetectable		 3elzB-2yv1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 2yv1 SUCCINYL-COA LIGASE
[ADP-FORMING]
SUBUNIT ALPHA
(Methanocaldococc
us
jannaschii) 		4 / 6 ILE A 281
MET A 155
ILE A 170
HIS A 168
 None
 1.08A 3eteA-2yv1A:
7.1
3eteE-2yv1A:
6.2		 3eteA-2yv1A:
21.41
3eteE-2yv1A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 2yv1 SUCCINYL-COA LIGASE
[ADP-FORMING]
SUBUNIT ALPHA
(Methanocaldococc
us
jannaschii) 		4 / 5 ILE A 281
MET A 155
ILE A 170
HIS A 168
 None
 1.09A 3eteB-2yv1A:
6.5
3eteC-2yv1A:
7.0		 3eteB-2yv1A:
21.41
3eteC-2yv1A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 2yv1 SUCCINYL-COA LIGASE
[ADP-FORMING]
SUBUNIT ALPHA
(Methanocaldococc
us
jannaschii) 		4 / 7 MET A 155
ILE A 170
HIS A 168
ILE A 281
 None
 1.07A 3eteD-2yv1A:
7.0
3eteF-2yv1A:
6.5		 3eteD-2yv1A:
21.41
3eteF-2yv1A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2yv1 SUCCINYL-COA LIGASE
[ADP-FORMING]
SUBUNIT ALPHA
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A 142
PHE A  77
THR A  38
ILE A  40
THR A 129
 None
 1.34A 3um5A-2yv1A:
undetectable		 3um5A-2yv1A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2yv1 SUCCINYL-COA LIGASE
[ADP-FORMING]
SUBUNIT ALPHA
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 292
LEU A 288
ILE A 291
GLY A 154
SER A 152
 None
 0.89A 4lmnA-2yv1A:
undetectable		 4lmnA-2yv1A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2yv1 SUCCINYL-COA LIGASE
[ADP-FORMING]
SUBUNIT ALPHA
(Methanocaldococc
us
jannaschii) 		4 / 8 THR A  69
GLY A  42
GLY A  43
VAL A  44
 None
 0.84A 4qvvY-2yv1A:
undetectable
4qvvZ-2yv1A:
undetectable		 4qvvY-2yv1A:
22.00
4qvvZ-2yv1A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 2yv1 SUCCINYL-COA LIGASE
[ADP-FORMING]
SUBUNIT ALPHA
(Methanocaldococc
us
jannaschii) 		5 / 9 LEU A 140
VAL A 181
ILE A 183
GLY A 190
ILE A 124
 None
 1.12A 5kqxB-2yv1A:
undetectable		 5kqxB-2yv1A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 2yv1 SUCCINYL-COA LIGASE
[ADP-FORMING]
SUBUNIT ALPHA
(Methanocaldococc
us
jannaschii) 		4 / 7 ARG A 158
TYR A 193
GLU A 220
LEU A 162
 None
 1.01A 5umwB-2yv1A:
undetectable
5umwE-2yv1A:
undetectable		 5umwB-2yv1A:
14.13
5umwE-2yv1A:
14.13