SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yv2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		4 / 5 LYS A 121
ALA A 123
ASP A  93
GLY A  95
 None
 0.92A 1e7bA-2yv2A:
undetectable		 1e7bA-2yv2A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		3 / 3 ASP A  86
ASP A  93
ASP A 110
 None
 0.66A 1eizA-2yv2A:
7.2		 1eizA-2yv2A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		3 / 3 ASP A  86
ASP A  93
ASP A 110
 None
 0.68A 1ej0A-2yv2A:
7.1		 1ej0A-2yv2A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		5 / 11 VAL A 237
LEU A 210
MET A 227
LEU A 198
GLN A 202
 None
 1.11A 1rlbF-2yv2A:
undetectable		 1rlbF-2yv2A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		5 / 11 ILE A 241
VAL A 270
LEU A 273
ARG A 274
VAL A 278
 None
 1.01A 2kawA-2yv2A:
undetectable		 2kawA-2yv2A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		4 / 7 VAL A  53
ILE A  21
ALA A  30
GLY A  55
 None
 0.74A 2xrzB-2yv2A:
undetectable		 2xrzB-2yv2A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		5 / 10 ILE A 134
GLY A 183
THR A 164
PRO A 136
ILE A 182
 None
 1.38A 2y7wB-2yv2A:
1.8		 2y7wB-2yv2A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		5 / 12 GLY A 183
GLY A 191
GLY A 127
ILE A 189
ASP A 187
 None
 1.08A 2zbpA-2yv2A:
7.4		 2zbpA-2yv2A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		5 / 12 VAL A  10
ALA A 155
THR A  38
VAL A  16
THR A  14
 None
 1.02A 3czhA-2yv2A:
undetectable		 3czhA-2yv2A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		3 / 3 ASP A  86
ASP A  93
ASP A 110
 None
 0.68A 3douA-2yv2A:
5.6		 3douA-2yv2A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		4 / 6 ILE A 182
PRO A 136
ILE A 176
VAL A 237
 None
 0.76A 3n3iA-2yv2A:
undetectable		 3n3iA-2yv2A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		5 / 12 LEU A  17
ALA A  30
GLY A  26
GLY A  43
ALA A  32
 None
 1.08A 3ou6A-2yv2A:
3.3		 3ou6A-2yv2A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		5 / 12 LEU A  17
ALA A  30
GLY A  26
GLY A  43
ALA A  32
 None
 1.09A 3ou6B-2yv2A:
3.9		 3ou6B-2yv2A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		5 / 9 ILE A 228
ALA A 224
VAL A 157
PHE A 194
LEU A 210
 None
 1.32A 3ti1A-2yv2A:
undetectable		 3ti1A-2yv2A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		5 / 12 ILE A 213
SER A 160
ILE A 126
VAL A 237
PHE A 194
 None
 0.95A 3vw1D-2yv2A:
undetectable		 3vw1D-2yv2A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		3 / 3 ASP A 187
GLU A 104
GLY A 105
 None
 0.61A 3w9tA-2yv2A:
undetectable		 3w9tA-2yv2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		4 / 7 LEU A 192
ALA A 133
VAL A  16
ILE A 126
 None
 0.88A 3wsjB-2yv2A:
undetectable		 3wsjB-2yv2A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		5 / 10 ARG A 119
GLY A 185
ILE A 184
VAL A 115
ILE A 189
 None
 1.11A 4dqcA-2yv2A:
undetectable		 4dqcA-2yv2A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		3 / 3 GLY A 152
GLU A 208
THR A 207
 None
 0.43A 4kouA-2yv2A:
undetectable		 4kouA-2yv2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		4 / 6 GLU A 279
TYR A 240
GLU A 286
GLU A 282
 None
 1.25A 4mi4A-2yv2A:
undetectable		 4mi4A-2yv2A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		4 / 7 GLU A 279
TYR A 240
GLU A 286
GLU A 282
 None
 1.29A 4mi4A-2yv2A:
undetectable
4mi4C-2yv2A:
undetectable		 4mi4A-2yv2A:
22.37
4mi4C-2yv2A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		4 / 8 GLU A 279
TYR A 240
GLU A 286
GLU A 282
 None
 1.22A 4mj8A-2yv2A:
undetectable
4mj8C-2yv2A:
undetectable		 4mj8A-2yv2A:
21.93
4mj8C-2yv2A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		4 / 7 GLU A 279
TYR A 240
GLU A 286
GLU A 282
 None
 1.31A 4mj8C-2yv2A:
undetectable		 4mj8C-2yv2A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		5 / 9 LEU A 192
GLY A 185
ASP A 187
VAL A 115
THR A 124
 None
 1.16A 4njtD-2yv2A:
undetectable		 4njtD-2yv2A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		5 / 9 LEU A 210
LEU A   9
SER A 179
THR A 180
ILE A 182
 None
 1.29A 4ubsA-2yv2A:
undetectable		 4ubsA-2yv2A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		5 / 12 ALA A  30
GLY A  43
GLY A  55
GLU A  90
LEU A  17
 None
 0.90A 5c0oG-2yv2A:
5.9		 5c0oG-2yv2A:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		3 / 3 MET A 170
GLN A 174
ARG A 173
 None
 1.09A 5ewzB-2yv2A:
undetectable		 5ewzB-2yv2A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		4 / 5 GLU A  13
THR A  14
THR A 124
LEU A 200
 None
 1.14A 5hm8A-2yv2A:
2.8		 5hm8A-2yv2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		4 / 5 GLU A  13
THR A  14
THR A 124
LEU A 200
 None
 1.15A 5hm8B-2yv2A:
2.3		 5hm8B-2yv2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		4 / 5 GLU A  13
THR A  14
THR A 124
LEU A 200
 None
 1.14A 5hm8C-2yv2A:
2.8		 5hm8C-2yv2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		4 / 5 GLU A  13
THR A  14
THR A 124
LEU A 200
 None
 1.15A 5hm8D-2yv2A:
2.2		 5hm8D-2yv2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		4 / 5 GLU A  13
THR A  14
THR A 124
LEU A 200
 None
 1.15A 5hm8E-2yv2A:
3.4		 5hm8E-2yv2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		4 / 5 GLU A  13
THR A  14
THR A 124
LEU A 200
 None
 1.14A 5hm8F-2yv2A:
3.3		 5hm8F-2yv2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		4 / 5 GLU A  13
THR A  14
THR A 124
LEU A 200
 None
 1.14A 5hm8G-2yv2A:
3.4		 5hm8G-2yv2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		4 / 5 GLU A  13
THR A  14
THR A 124
LEU A 200
 None
 1.15A 5hm8H-2yv2A:
2.3		 5hm8H-2yv2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		3 / 3 MET A 170
GLN A 174
ARG A 173
 None
 1.06A 5m35B-2yv2A:
undetectable		 5m35B-2yv2A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		3 / 3 MET A 170
GLN A 174
ARG A 173
 None
 1.06A 5m36A-2yv2A:
undetectable		 5m36A-2yv2A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		3 / 3 THR A  14
THR A 124
LEU A 200
 None
 0.71A 5m66D-2yv2A:
2.4		 5m66D-2yv2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_B_PFLB410_1
(PROTON-GATED ION
CHANNEL)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		5 / 9 PRO A 131
ILE A 182
ILE A 184
THR A 164
ILE A 213
 None
 1.33A 5mvnB-2yv2A:
undetectable		 5mvnB-2yv2A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_B_PFLB410_1
(PROTON-GATED ION
CHANNEL)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		5 / 9 PRO A 131
ILE A 184
VAL A 181
THR A 164
ILE A 213
 None
 1.47A 5mvnB-2yv2A:
undetectable		 5mvnB-2yv2A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		5 / 12 ILE A 126
GLY A 183
VAL A 157
VAL A 156
VAL A  10
 None
 1.21A 5n0rA-2yv2A:
undetectable		 5n0rA-2yv2A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		5 / 12 ILE A 126
GLY A 183
VAL A 157
VAL A 156
VAL A  10
 None
 1.19A 5n0wA-2yv2A:
undetectable		 5n0wA-2yv2A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		5 / 9 THR A 124
ALA A 118
GLY A 191
LEU A 192
SER A 193
 None
 1.25A 5vw4A-2yv2A:
undetectable		 5vw4A-2yv2A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		4 / 6 ALA A 139
GLN A 138
GLN A 206
ASP A 204
 None
 1.06A 5y9aA-2yv2A:
3.9		 5y9aA-2yv2A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		3 / 3 VAL A  56
GLU A  52
ILE A  21
 None
 0.57A 6f7lB-2yv2A:
4.4		 6f7lB-2yv2A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		3 / 3 MET A 170
GLN A 174
ARG A 173
 None
 1.06A 6fn9A-2yv2A:
undetectable		 6fn9A-2yv2A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		3 / 3 MET A 170
GLN A 174
ARG A 173
 None
 1.09A 6fnaB-2yv2A:
undetectable		 6fnaB-2yv2A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN
(Aeropyrum
pernix) 		3 / 3 MET A 170
GLN A 174
ARG A 173
 None
 1.06A 6fnbA-2yv2A:
undetectable		 6fnbA-2yv2A:
23.36