SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yv3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 ALA A 149
SER A 226
THR A 228
VAL A 230
 None
 0.88A 1dvxB-2yv3A:
undetectable		 1dvxB-2yv3A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU A 318
ARG A  96
ILE A 129
GLY A 309
LEU A 313
 None
 1.24A 1g50B-2yv3A:
undetectable		 1g50B-2yv3A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 LEU A 318
ARG A  96
ILE A 129
GLY A 309
LEU A 313
 None
 1.24A 1g50C-2yv3A:
undetectable		 1g50C-2yv3A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 LEU A 259
GLY A 264
VAL A 268
GLY A 309
ILE A 129
 None
 0.94A 1hxwB-2yv3A:
undetectable		 1hxwB-2yv3A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 ILE A  16
ALA A 320
VAL A  19
ARG A  23
LEU A  43
 None
 1.22A 1n4hA-2yv3A:
undetectable		 1n4hA-2yv3A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 TYR A  97
PRO A  99
THR A 127
THR A 214
 None
 1.42A 1ymxB-2yv3A:
undetectable		 1ymxB-2yv3A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A600_1
(ORF12)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 LYS A 209
SER A  74
TYR A  97
GLY A  71
ARG A 205
 None
 1.21A 2xf3A-2yv3A:
1.9		 2xf3A-2yv3A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B600_1
(ORF12)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 LYS A 209
SER A  74
TYR A  97
GLY A  71
ARG A 205
 None
 1.22A 2xf3B-2yv3A:
1.8		 2xf3B-2yv3A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 LYS A 209
SER A  74
TYR A  97
GLY A  71
ARG A 205
 None
 1.25A 2xh9A-2yv3A:
1.8		 2xh9A-2yv3A:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1437_1
(ORF12)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 LYS A 209
SER A  74
TYR A  97
GLY A  71
ARG A 205
 None
 1.22A 2xh9B-2yv3A:
1.7		 2xh9B-2yv3A:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 TYR A 276
MET A 278
THR A 281
LEU A 280
 None
 1.24A 3ag1J-2yv3A:
undetectable		 3ag1J-2yv3A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 TYR A 276
MET A 278
THR A 281
LEU A 280
 None
 1.32A 3ag2J-2yv3A:
undetectable		 3ag2J-2yv3A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 TYR A 276
MET A 278
THR A 281
LEU A 280
 None
 1.32A 3ag4J-2yv3A:
undetectable		 3ag4J-2yv3A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 ALA A 149
SER A 226
THR A 228
VAL A 230
 None
 1.04A 3d2tB-2yv3A:
undetectable		 3d2tB-2yv3A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 LEU A 259
GLY A 264
VAL A 268
GLY A 309
ILE A 129
 None
 0.94A 3nujB-2yv3A:
undetectable		 3nujB-2yv3A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 ALA A 149
SER A 226
THR A 228
VAL A 230
 None
 0.87A 3ozkB-2yv3A:
undetectable		 3ozkB-2yv3A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 PRO A 188
ALA A 180
GLU A 164
GLN A 311
 None
 1.11A 4g0uA-2yv3A:
undetectable		 4g0uA-2yv3A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 PRO A 277
MET A 278
TYR A 276
 None
 1.01A 4qa0B-2yv3A:
undetectable		 4qa0B-2yv3A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 PRO A 277
MET A 278
TYR A 276
 None
 1.02A 4qa0A-2yv3A:
undetectable		 4qa0A-2yv3A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 PRO A 277
MET A 278
TYR A 276
 None
 0.82A 4qa2B-2yv3A:
undetectable		 4qa2B-2yv3A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIW_B_AZMB402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLU A 213
LEU A 130
THR A 127
THR A 126
VAL A 242
 None
 0.82A 4xiwB-2yv3A:
undetectable
4xiwE-2yv3A:
undetectable		 4xiwB-2yv3A:
20.63
4xiwE-2yv3A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 ALA A 282
THR A 281
VAL A 268
GLU A 266
 None
 1.20A 5ecnA-2yv3A:
undetectable		 5ecnA-2yv3A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ILE A 147
TRP A 135
ILE A 217
ALA A 131
LEU A 134
 None
 1.04A 5oy02-2yv3A:
undetectable		 5oy02-2yv3A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 VAL A 232
TYR A 151
GLN A 152
 None
 0.51A 5qgkA-2yv3A:
undetectable		 5qgkA-2yv3A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 VAL A 232
TYR A 151
GLN A 152
 None
 0.50A 5qgrA-2yv3A:
undetectable		 5qgrA-2yv3A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 VAL A 232
TYR A 151
GLN A 152
 None
 0.48A 5qgtA-2yv3A:
undetectable		 5qgtA-2yv3A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 TYR A 276
MET A 278
THR A 281
LEU A 280
 None
 1.17A 5w97J-2yv3A:
undetectable		 5w97J-2yv3A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 TYR A 276
MET A 278
THR A 281
LEU A 280
 None
 1.29A 5wauJ-2yv3A:
undetectable		 5wauJ-2yv3A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 TYR A 276
MET A 278
THR A 281
LEU A 280
 None
 1.21A 5x19J-2yv3A:
undetectable		 5x19J-2yv3A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 TYR A 276
MET A 278
THR A 281
LEU A 280
 None
 1.28A 5x1bW-2yv3A:
undetectable		 5x1bW-2yv3A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 TYR A 276
MET A 278
THR A 281
LEU A 280
 None
 1.21A 5x1fW-2yv3A:
undetectable		 5x1fW-2yv3A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 ILE A 147
TRP A 135
ILE A 217
ALA A 131
LEU A 134
 None
 1.04A 5zjiB-2yv3A:
undetectable		 5zjiB-2yv3A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 SER A  74
GLY A 158
SER A 155
ALA A 153
VAL A  12
 None
 1.44A 6hu9L-2yv3A:
undetectable
6hu9P-2yv3A:
undetectable
6hu9T-2yv3A:
undetectable		 6hu9L-2yv3A:
20.00
6hu9P-2yv3A:
21.61
6hu9T-2yv3A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 TYR A 276
MET A 278
THR A 281
LEU A 280
 None
 1.21A 6nknJ-2yv3A:
undetectable		 6nknJ-2yv3A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yv3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 TYR A 276
MET A 278
THR A 281
LEU A 280
 None
 1.22A 6nknW-2yv3A:
undetectable		 6nknW-2yv3A:
10.24