SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yv4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 2yv4 HYPOTHETICAL PROTEIN
PH0435
(Pyrococcus
horikoshii) 		4 / 8 LEU A 329
VAL A 292
LEU A 285
ALA A 299
 None
 0.69A 1fiqC-2yv4A:
undetectable		 1fiqC-2yv4A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 2yv4 HYPOTHETICAL PROTEIN
PH0435
(Pyrococcus
horikoshii) 		5 / 10 LEU A 262
VAL A 271
VAL A 308
GLY A 270
LEU A 258
 None
 1.19A 1fkoA-2yv4A:
undetectable		 1fkoA-2yv4A:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		 2yv4 HYPOTHETICAL PROTEIN
PH0435
(Pyrococcus
horikoshii) 		5 / 9 LEU A 262
VAL A 271
VAL A 308
GLY A 270
LEU A 258
 None
 1.22A 1ikvA-2yv4A:
undetectable		 1ikvA-2yv4A:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		 2yv4 HYPOTHETICAL PROTEIN
PH0435
(Pyrococcus
horikoshii) 		5 / 10 LEU A 262
VAL A 271
VAL A 308
GLY A 270
LEU A 258
 None
 1.20A 1ikwA-2yv4A:
undetectable		 1ikwA-2yv4A:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		 2yv4 HYPOTHETICAL PROTEIN
PH0435
(Pyrococcus
horikoshii) 		5 / 11 LEU A 262
VAL A 271
VAL A 308
GLY A 270
LEU A 258
 None
 1.32A 1jkhA-2yv4A:
undetectable
1jkhB-2yv4A:
undetectable		 1jkhA-2yv4A:
10.29
1jkhB-2yv4A:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGR_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 2yv4 HYPOTHETICAL PROTEIN
PH0435
(Pyrococcus
horikoshii) 		5 / 11 LEU A 285
VAL A 271
TYR A 335
LEU A 296
GLU A 314
 None
 1.15A 3bgrA-2yv4A:
undetectable
3bgrB-2yv4A:
undetectable		 3bgrA-2yv4A:
10.25
3bgrB-2yv4A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2yv4 HYPOTHETICAL PROTEIN
PH0435
(Pyrococcus
horikoshii) 		4 / 8 LEU A 329
VAL A 292
LEU A 285
ALA A 299
 None
 0.68A 3uniB-2yv4A:
2.7		 3uniB-2yv4A:
6.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2yv4 HYPOTHETICAL PROTEIN
PH0435
(Pyrococcus
horikoshii) 		5 / 10 LEU A 262
VAL A 271
VAL A 308
GLY A 270
LEU A 258
 None
 1.27A 6bsgA-2yv4A:
undetectable		 6bsgA-2yv4A:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2yv4 HYPOTHETICAL PROTEIN
PH0435
(Pyrococcus
horikoshii) 		5 / 10 LEU A 262
VAL A 271
VAL A 308
GLY A 270
LEU A 258
 None
 1.20A 6bsiA-2yv4A:
undetectable		 6bsiA-2yv4A:
26.17