SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yv5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 2yv5 YJEQ PROTEIN
(Aquifex
aeolicus) 		4 / 6 PRO A 113
ASN A 101
ASP A 100
TYR A 143
 None
 1.25A 1hpkA-2yv5A:
undetectable		 1hpkA-2yv5A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OXR_A_AINA141_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 2yv5 YJEQ PROTEIN
(Aquifex
aeolicus) 		4 / 4 LEU A  10
GLY A 165
ASP A  81
TYR A  49
 None
 1.19A 1oxrA-2yv5A:
undetectable		 1oxrA-2yv5A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 2yv5 YJEQ PROTEIN
(Aquifex
aeolicus) 		4 / 4 LEU A 163
PRO A 224
ILE A 181
LEU A 185
 None
 0.86A 1ya4B-2yv5A:
1.2		 1ya4B-2yv5A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 2yv5 YJEQ PROTEIN
(Aquifex
aeolicus) 		4 / 4 LEU A 163
PRO A 224
ILE A 181
LEU A 185
 None
 0.87A 1ya4C-2yv5A:
undetectable		 1ya4C-2yv5A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2yv5 YJEQ PROTEIN
(Aquifex
aeolicus) 		4 / 6 SER A 218
PHE A 166
ARG A  82
GLU A 164
 None
 1.37A 2c8aC-2yv5A:
undetectable		 2c8aC-2yv5A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2yv5 YJEQ PROTEIN
(Aquifex
aeolicus) 		3 / 3 THR A  88
SER A 174
LYS A 228
 None
GDP  A1001 ( 4.1A)
None
 1.14A 3aocC-2yv5A:
undetectable		 3aocC-2yv5A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 2yv5 YJEQ PROTEIN
(Aquifex
aeolicus) 		4 / 7 PHE A  24
GLY A  27
GLY A 217
PHE A  60
 None
 0.88A 3ko0M-2yv5A:
0.0
3ko0P-2yv5A:
undetectable		 3ko0M-2yv5A:
17.54
3ko0P-2yv5A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2yv5 YJEQ PROTEIN
(Aquifex
aeolicus) 		5 / 12 SER A 218
PHE A 214
LEU A 146
VAL A 148
VAL A 114
 None
 1.38A 3u9fB-2yv5A:
undetectable
3u9fC-2yv5A:
undetectable		 3u9fB-2yv5A:
22.58
3u9fC-2yv5A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2yv5 YJEQ PROTEIN
(Aquifex
aeolicus) 		5 / 10 SER A 218
PHE A 214
LEU A 146
VAL A 148
VAL A 114
 None
 1.26A 3u9fE-2yv5A:
undetectable		 3u9fE-2yv5A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2yv5 YJEQ PROTEIN
(Aquifex
aeolicus) 		5 / 12 SER A 218
PHE A 214
LEU A 146
VAL A 148
VAL A 114
 None
 1.33A 3u9fJ-2yv5A:
undetectable
3u9fK-2yv5A:
undetectable		 3u9fJ-2yv5A:
22.58
3u9fK-2yv5A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2yv5 YJEQ PROTEIN
(Aquifex
aeolicus) 		5 / 12 ILE A 288
TYR A 284
LEU A 285
LEU A 298
HIS A 259
 None
None
None
None
ZN  A 303 ( 3.2A)
 1.49A 3vn2A-2yv5A:
undetectable		 3vn2A-2yv5A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 2yv5 YJEQ PROTEIN
(Aquifex
aeolicus) 		4 / 8 TYR A  97
ASN A 101
ILE A 288
SER A 283
 None
 0.96A 4eyzA-2yv5A:
undetectable		 4eyzA-2yv5A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 2yv5 YJEQ PROTEIN
(Aquifex
aeolicus) 		4 / 8 TYR A  97
ASN A 101
ILE A 288
SER A 283
 None
 0.95A 4eyzB-2yv5A:
undetectable		 4eyzB-2yv5A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 2yv5 YJEQ PROTEIN
(Aquifex
aeolicus) 		3 / 3 PRO A  92
LEU A  99
SER A 174
 None
None
GDP  A1001 ( 4.1A)
 0.85A 5fsaB-2yv5A:
undetectable		 5fsaB-2yv5A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2yv5 YJEQ PROTEIN
(Aquifex
aeolicus) 		5 / 12 LEU A 170
ILE A 169
GLY A 225
SER A 179
LEU A 182
 None
None
None
GDP  A1001 (-4.5A)
None
 1.08A 5twjC-2yv5A:
undetectable		 5twjC-2yv5A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 2yv5 YJEQ PROTEIN
(Aquifex
aeolicus) 		4 / 6 THR A  59
ARG A  31
ILE A  62
GLU A  63
 None
 1.19A 5uigA-2yv5A:
undetectable		 5uigA-2yv5A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2yv5 YJEQ PROTEIN
(Aquifex
aeolicus) 		5 / 12 GLY A 208
LYS A 205
VAL A  50
GLY A  20
ILE A  19
 None
 1.07A 5vooB-2yv5A:
2.5		 5vooB-2yv5A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2yv5 YJEQ PROTEIN
(Aquifex
aeolicus) 		5 / 12 GLY A 208
VAL A  50
LEU A  10
GLY A  20
ILE A  19
 None
 1.16A 5vooE-2yv5A:
undetectable		 5vooE-2yv5A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2yv5 YJEQ PROTEIN
(Aquifex
aeolicus) 		5 / 12 GLY A 208
VAL A  50
LEU A  10
GLY A  20
ILE A  19
 None
 1.18A 5vooF-2yv5A:
2.2		 5vooF-2yv5A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2yv5 YJEQ PROTEIN
(Aquifex
aeolicus) 		5 / 12 GLY A 208
VAL A  50
LEU A  10
GLY A  20
ILE A  19
 None
 1.12A 5vopB-2yv5A:
2.2		 5vopB-2yv5A:
23.24