SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yv9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2yv9 CHLORIDE
INTRACELLULAR
CHANNEL EXC-4
(Caenorhabditis
elegans) 		4 / 8 GLU A 259
ASP A 240
ILE A 244
ILE A 204
 None
 0.82A 1p7lD-2yv9A:
undetectable		 1p7lD-2yv9A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2yv9 CHLORIDE
INTRACELLULAR
CHANNEL EXC-4
(Caenorhabditis
elegans) 		4 / 8 GLU A 259
ASP A 240
ILE A 244
ILE A 204
 None
 0.83A 1p7lC-2yv9A:
undetectable		 1p7lC-2yv9A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2yv9 CHLORIDE
INTRACELLULAR
CHANNEL EXC-4
(Caenorhabditis
elegans) 		4 / 8 GLU A 259
ASP A 240
ILE A 244
ILE A 204
 None
 0.81A 1rg9B-2yv9A:
undetectable		 1rg9B-2yv9A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2yv9 CHLORIDE
INTRACELLULAR
CHANNEL EXC-4
(Caenorhabditis
elegans) 		4 / 8 GLU A 259
ASP A 240
ILE A 244
ILE A 204
 None
 0.83A 1rg9A-2yv9A:
undetectable		 1rg9A-2yv9A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2yv9 CHLORIDE
INTRACELLULAR
CHANNEL EXC-4
(Caenorhabditis
elegans) 		4 / 8 GLU A 259
ASP A 240
ILE A 244
ILE A 204
 None
 0.82A 1rg9D-2yv9A:
undetectable		 1rg9D-2yv9A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2yv9 CHLORIDE
INTRACELLULAR
CHANNEL EXC-4
(Caenorhabditis
elegans) 		4 / 8 GLU A 259
ASP A 240
ILE A 244
ILE A 204
 None
 0.83A 1rg9C-2yv9A:
undetectable		 1rg9C-2yv9A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		 2yv9 CHLORIDE
INTRACELLULAR
CHANNEL EXC-4
(Caenorhabditis
elegans) 		5 / 12 ALA A 239
ARG A  32
GLN A 262
SER A  26
GLY A  27
 None
 1.19A 2xffA-2yv9A:
undetectable		 2xffA-2yv9A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 2yv9 CHLORIDE
INTRACELLULAR
CHANNEL EXC-4
(Caenorhabditis
elegans) 		3 / 3 PHE A  38
ASN A  93
PHE A  42
 None
CA  A1002 (-3.8A)
None
 0.99A 2zbuD-2yv9A:
undetectable		 2zbuD-2yv9A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 2yv9 CHLORIDE
INTRACELLULAR
CHANNEL EXC-4
(Caenorhabditis
elegans) 		3 / 3 LYS A  16
PRO A  17
LEU A  18
 None
 0.81A 3tpxE-2yv9A:
undetectable		 3tpxE-2yv9A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2yv9 CHLORIDE
INTRACELLULAR
CHANNEL EXC-4
(Caenorhabditis
elegans) 		4 / 8 GLU A 259
ASP A 240
ILE A 244
ILE A 204
 None
 0.90A 4kttB-2yv9A:
undetectable		 4kttB-2yv9A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2yv9 CHLORIDE
INTRACELLULAR
CHANNEL EXC-4
(Caenorhabditis
elegans) 		4 / 8 GLU A 259
ASP A 240
ILE A 244
ILE A 204
 None
 0.86A 4kttD-2yv9A:
undetectable		 4kttD-2yv9A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2yv9 CHLORIDE
INTRACELLULAR
CHANNEL EXC-4
(Caenorhabditis
elegans) 		4 / 8 GLU A 259
ASP A 240
ILE A 244
ILE A 204
 None
 0.88A 4ndnB-2yv9A:
undetectable		 4ndnB-2yv9A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2yv9 CHLORIDE
INTRACELLULAR
CHANNEL EXC-4
(Caenorhabditis
elegans) 		4 / 8 GLU A 259
ASP A 240
ILE A 244
ILE A 204
 None
 0.88A 4ndnD-2yv9A:
undetectable		 4ndnD-2yv9A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2yv9 CHLORIDE
INTRACELLULAR
CHANNEL EXC-4
(Caenorhabditis
elegans) 		4 / 8 GLU A 259
ASP A 240
ILE A 244
ILE A 204
 None
 0.88A 5t8sA-2yv9A:
undetectable		 5t8sA-2yv9A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2yv9 CHLORIDE
INTRACELLULAR
CHANNEL EXC-4
(Caenorhabditis
elegans) 		4 / 7 GLU A 259
ASP A 240
ILE A 244
ILE A 204
 None
 0.96A 6fbnA-2yv9A:
undetectable		 6fbnA-2yv9A:
22.28