SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yva'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA
(Escherichia
coli) 		5 / 12 VAL A 140
LEU A 114
ILE A  27
ALA A  31
LEU A  34
 None
 0.93A 1cqeA-2yvaA:
undetectable		 1cqeA-2yvaA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA
(Escherichia
coli) 		5 / 12 VAL A 140
LEU A 114
ILE A  27
ALA A  31
LEU A  34
 None
 0.94A 1cqeB-2yvaA:
undetectable		 1cqeB-2yvaA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA
(Escherichia
coli) 		5 / 9 VAL A 140
LEU A 114
ILE A  27
ALA A  31
LEU A  34
 None
 0.94A 1eqgA-2yvaA:
0.3		 1eqgA-2yvaA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA
(Escherichia
coli) 		5 / 11 VAL A 140
LEU A 114
ILE A  27
ALA A  31
LEU A  34
 None
 0.96A 1eqgB-2yvaA:
0.9		 1eqgB-2yvaA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA
(Escherichia
coli) 		5 / 12 VAL A 140
LEU A 114
ILE A  27
ALA A  31
LEU A  34
 None
 0.94A 1eqhA-2yvaA:
1.0		 1eqhA-2yvaA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA
(Escherichia
coli) 		5 / 12 VAL A 140
LEU A 114
ILE A  27
ALA A  31
LEU A  34
 None
 0.97A 1eqhB-2yvaA:
1.0		 1eqhB-2yvaA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA
(Escherichia
coli) 		5 / 10 LEU A  45
LEU A  79
ILE A 125
THR A 138
ILE A 139
 None
 1.37A 1i18A-2yvaA:
undetectable
1i18B-2yvaA:
undetectable		 1i18A-2yvaA:
21.03
1i18B-2yvaA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA
(Escherichia
coli) 		5 / 10 THR A 138
ILE A 139
LEU A  45
LEU A  79
ILE A 125
 None
 1.36A 1i18A-2yvaA:
undetectable
1i18B-2yvaA:
undetectable		 1i18A-2yvaA:
21.03
1i18B-2yvaA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA
(Escherichia
coli) 		4 / 6 ASN A 121
HIS A 166
TYR A 145
GLY A 147
 None
 1.29A 1mxdA-2yvaA:
undetectable		 1mxdA-2yvaA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA
(Escherichia
coli) 		4 / 7 ASN A 121
HIS A 166
TYR A 145
GLY A 147
 None
 1.30A 1mxgA-2yvaA:
undetectable		 1mxgA-2yvaA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA
(Escherichia
coli) 		5 / 12 LEU A 113
LEU A  34
ILE A 161
THR A 178
ILE A 125
 None
 1.20A 1tw4B-2yvaA:
undetectable		 1tw4B-2yvaA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA
(Escherichia
coli) 		5 / 12 VAL A 140
LEU A 114
ILE A  27
ALA A  31
LEU A  34
 None
 0.93A 2aylB-2yvaA:
undetectable		 2aylB-2yvaA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA
(Escherichia
coli) 		5 / 10 ALA A 115
LEU A 182
ALA A  30
LEU A 113
VAL A 112
 None
 1.17A 2bxeA-2yvaA:
undetectable		 2bxeA-2yvaA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA
(Escherichia
coli) 		4 / 5 LYS A  43
PRO A  75
SER A  73
LEU A  45
 None
 1.15A 3iluH-2yvaA:
undetectable		 3iluH-2yvaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA
(Escherichia
coli) 		5 / 6 VAL A 129
SER A 117
ILE A 171
ALA A 141
LEU A 154
 None
 1.46A 3kk6B-2yvaA:
undetectable		 3kk6B-2yvaA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDZ_A_EZLA264_1
(CARBONIC ANHYDRASE 7)		 2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA
(Escherichia
coli) 		5 / 11 HIS A 175
VAL A 140
ALA A  31
LEU A 182
THR A 178
 None
 1.22A 3mdzA-2yvaA:
undetectable		 3mdzA-2yvaA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA
(Escherichia
coli) 		4 / 8 SER A  12
LEU A 177
ALA A  20
ALA A  19
 None
 0.71A 3ns1L-2yvaA:
undetectable		 3ns1L-2yvaA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA
(Escherichia
coli) 		5 / 12 LEU A 113
CYH A  47
HIS A 175
LEU A 150
GLY A 120
 None
 1.31A 3okxA-2yvaA:
undetectable		 3okxA-2yvaA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA
(Escherichia
coli) 		5 / 12 LEU A 113
CYH A  47
HIS A 175
LEU A 150
GLY A 120
 None
 1.31A 3okxB-2yvaA:
undetectable		 3okxB-2yvaA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4A_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA
(Escherichia
coli) 		4 / 8 THR A 178
THR A  33
LEU A 142
VAL A 140
 None
 0.97A 4l4aA-2yvaA:
undetectable		 4l4aA-2yvaA:
19.85