SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yvp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 2yvp MUTT/NUDIX FAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 12 THR A 134
GLY A  96
VAL A  95
GLU A  94
GLU A 139
 None
None
None
MG  A 184 (-2.5A)
MG  A 183 (-2.5A)
 1.42A 1jdvE-2yvpA:
undetectable
1jdvF-2yvpA:
undetectable		 1jdvE-2yvpA:
21.43
1jdvF-2yvpA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 2yvp MUTT/NUDIX FAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 144
LEU A  70
LEU A  47
PRO A  48
LEU A  91
 None
 1.03A 1og5A-2yvpA:
undetectable		 1og5A-2yvpA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2yvp MUTT/NUDIX FAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 10 THR A 134
GLY A  96
VAL A  95
GLU A  94
GLU A 139
 None
None
None
MG  A 184 (-2.5A)
MG  A 183 (-2.5A)
 1.36A 1z35A-2yvpA:
undetectable		 1z35A-2yvpA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2yvp MUTT/NUDIX FAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 9 THR A 134
GLY A  96
VAL A  95
GLU A  94
GLU A 139
 None
None
None
MG  A 184 (-2.5A)
MG  A 183 (-2.5A)
 1.39A 1z37A-2yvpA:
undetectable		 1z37A-2yvpA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_A_ADNA1216_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2yvp MUTT/NUDIX FAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 11 THR A 134
GLY A  96
VAL A  95
GLU A  94
GLU A 139
 None
None
None
MG  A 184 (-2.5A)
MG  A 183 (-2.5A)
 1.35A 2ac7A-2yvpA:
undetectable
2ac7B-2yvpA:
undetectable		 2ac7A-2yvpA:
20.92
2ac7B-2yvpA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_B_ADNB1215_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2yvp MUTT/NUDIX FAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 11 THR A 134
GLY A  96
VAL A  95
GLU A  94
GLU A 139
 None
None
None
MG  A 184 (-2.5A)
MG  A 183 (-2.5A)
 1.35A 2ac7A-2yvpA:
undetectable
2ac7B-2yvpA:
undetectable		 2ac7A-2yvpA:
20.92
2ac7B-2yvpA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 2yvp MUTT/NUDIX FAMILY
PROTEIN
(Thermus
thermophilus) 		4 / 7 GLU A 139
ARG A  62
GLU A  94
GLU A  90
 MG  A 183 (-2.5A)
RBY  A 186 (-3.2A)
MG  A 184 (-2.5A)
MG  A 183 (-2.6A)
 1.27A 2zt7A-2yvpA:
undetectable		 2zt7A-2yvpA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 2yvp MUTT/NUDIX FAMILY
PROTEIN
(Thermus
thermophilus) 		4 / 4 LEU A 169
ALA A  55
VAL A  49
PRO A  48
 None
 1.23A 3gv1B-2yvpA:
undetectable		 3gv1B-2yvpA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 2yvp MUTT/NUDIX FAMILY
PROTEIN
(Thermus
thermophilus) 		4 / 6 LEU A 102
GLU A  84
PRO A 104
ARG A  88
 None
 1.50A 3ltwA-2yvpA:
undetectable		 3ltwA-2yvpA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2yvp MUTT/NUDIX FAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 10 THR A 134
GLY A  96
VAL A  95
GLU A  94
GLU A 139
 None
None
None
MG  A 184 (-2.5A)
MG  A 183 (-2.5A)
 1.37A 3uayA-2yvpA:
undetectable		 3uayA-2yvpA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2yvp MUTT/NUDIX FAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 11 GLY A  96
VAL A  95
GLU A  94
GLU A 139
VAL A 129
 None
None
MG  A 184 (-2.5A)
MG  A 183 (-2.5A)
None
 1.28A 4danA-2yvpA:
undetectable		 4danA-2yvpA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 2yvp MUTT/NUDIX FAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 11 HIS A 120
SER A 107
LEU A 155
ASP A 162
VAL A  72
 None
 1.33A 4fogC-2yvpA:
undetectable		 4fogC-2yvpA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 2yvp MUTT/NUDIX FAMILY
PROTEIN
(Thermus
thermophilus) 		4 / 6 GLU A 139
ARG A  62
GLU A  94
GLU A  90
 MG  A 183 (-2.5A)
RBY  A 186 (-3.2A)
MG  A 184 (-2.5A)
MG  A 183 (-2.6A)
 1.45A 4kr3A-2yvpA:
undetectable		 4kr3A-2yvpA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2yvp MUTT/NUDIX FAMILY
PROTEIN
(Thermus
thermophilus) 		4 / 4 GLU A  84
PRO A 104
ILE A 103
LEU A 102
 None
 1.22A 5m45A-2yvpA:
undetectable		 5m45A-2yvpA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2yvp MUTT/NUDIX FAMILY
PROTEIN
(Thermus
thermophilus) 		4 / 4 GLU A  84
PRO A 104
ILE A 103
LEU A 102
 None
 1.18A 5m45D-2yvpA:
undetectable		 5m45D-2yvpA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2yvp MUTT/NUDIX FAMILY
PROTEIN
(Thermus
thermophilus) 		4 / 4 GLU A  84
PRO A 104
ILE A 103
LEU A 102
 None
 1.21A 5m45G-2yvpA:
undetectable		 5m45G-2yvpA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2yvp MUTT/NUDIX FAMILY
PROTEIN
(Thermus
thermophilus) 		4 / 4 GLU A  84
PRO A 104
ILE A 103
LEU A 102
 None
 1.21A 5m45J-2yvpA:
undetectable		 5m45J-2yvpA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 2yvp MUTT/NUDIX FAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 146
ARG A  59
LEU A  57
ILE A 160
GLU A 159
 None
 1.15A 5v0vA-2yvpA:
undetectable		 5v0vA-2yvpA:
16.64