SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yvq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 2yvq CARBAMOYL-PHOSPHATE
SYNTHASE
(Homo
sapiens) 		5 / 11 ASP A1429
GLY A1361
ILE A1362
ALA A1456
ILE A1427
 None
 1.14A 2idwA-2yvqA:
undetectable		 2idwA-2yvqA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2yvq CARBAMOYL-PHOSPHATE
SYNTHASE
(Homo
sapiens) 		4 / 7 THR A1391
VAL A1408
ILE A1423
ILE A1452
 None
 0.75A 3deuA-2yvqA:
undetectable		 3deuA-2yvqA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2yvq CARBAMOYL-PHOSPHATE
SYNTHASE
(Homo
sapiens) 		5 / 10 ILE A1432
PHE A1374
ALA A1474
LEU A1381
ALA A1378
 None
 1.30A 3lw5B-2yvqA:
undetectable		 3lw5B-2yvqA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2yvq CARBAMOYL-PHOSPHATE
SYNTHASE
(Homo
sapiens) 		3 / 3 PHE A1374
ILE A1364
ASP A1396
 None
 0.72A 5cswA-2yvqA:
undetectable		 5cswA-2yvqA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2yvq CARBAMOYL-PHOSPHATE
SYNTHASE
(Homo
sapiens) 		3 / 3 PHE A1374
ILE A1364
ASP A1396
 None
 0.70A 5cswB-2yvqA:
undetectable		 5cswB-2yvqA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2yvq CARBAMOYL-PHOSPHATE
SYNTHASE
(Homo
sapiens) 		3 / 3 LYS A1425
ASP A1429
ILE A1452
 None
 0.79A 5kc4E-2yvqA:
undetectable		 5kc4E-2yvqA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 2yvq CARBAMOYL-PHOSPHATE
SYNTHASE
(Homo
sapiens) 		5 / 12 ASP A1429
GLY A1361
ILE A1362
PRO A1462
ILE A1427
 None
 1.06A 5t2zA-2yvqA:
undetectable		 5t2zA-2yvqA:
18.88