SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yvs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 2yvs GLYCOLATE OXIDASE
SUBUNIT GLCE
(Thermus
thermophilus) 		4 / 8 LEU A 215
VAL A 218
THR A  69
VAL A  75
 None
 1.14A 1dz9A-2yvsA:
undetectable		 1dz9A-2yvsA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 2yvs GLYCOLATE OXIDASE
SUBUNIT GLCE
(Thermus
thermophilus) 		4 / 8 GLY A  51
ARG A  49
LEU A  46
VAL A  37
 None
 1.01A 1gsfA-2yvsA:
undetectable		 1gsfA-2yvsA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 2yvs GLYCOLATE OXIDASE
SUBUNIT GLCE
(Thermus
thermophilus) 		4 / 8 GLY A  51
ARG A  49
LEU A  46
VAL A  37
 None
 1.01A 1gsfB-2yvsA:
undetectable		 1gsfB-2yvsA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 2yvs GLYCOLATE OXIDASE
SUBUNIT GLCE
(Thermus
thermophilus) 		4 / 8 GLY A  51
ARG A  49
LEU A  46
VAL A  37
 None
 1.01A 1gsfC-2yvsA:
undetectable		 1gsfC-2yvsA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 2yvs GLYCOLATE OXIDASE
SUBUNIT GLCE
(Thermus
thermophilus) 		4 / 8 GLY A  51
ARG A  49
LEU A  46
VAL A  37
 None
 1.01A 1gsfD-2yvsA:
undetectable		 1gsfD-2yvsA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2yvs GLYCOLATE OXIDASE
SUBUNIT GLCE
(Thermus
thermophilus) 		5 / 12 GLY A  44
GLY A  42
GLY A  41
VAL A  47
GLY A 102
 None
 0.95A 1n2xB-2yvsA:
undetectable		 1n2xB-2yvsA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 2yvs GLYCOLATE OXIDASE
SUBUNIT GLCE
(Thermus
thermophilus) 		4 / 8 LEU A 215
VAL A 218
THR A  69
VAL A  75
 None
 1.14A 1o76B-2yvsA:
undetectable		 1o76B-2yvsA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 2yvs GLYCOLATE OXIDASE
SUBUNIT GLCE
(Thermus
thermophilus) 		4 / 7 PHE A  31
GLY A 155
PHE A  34
PHE A 137
 None
 1.14A 3ko0D-2yvsA:
undetectable
3ko0E-2yvsA:
undetectable		 3ko0D-2yvsA:
16.44
3ko0E-2yvsA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2yvs GLYCOLATE OXIDASE
SUBUNIT GLCE
(Thermus
thermophilus) 		4 / 8 ARG A  76
SER A  97
VAL A 108
GLY A  64
 None
 0.96A 4klrB-2yvsA:
undetectable		 4klrB-2yvsA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		 2yvs GLYCOLATE OXIDASE
SUBUNIT GLCE
(Thermus
thermophilus) 		5 / 9 GLN A  54
GLY A  51
GLY A  50
ALA A  48
VAL A  95
 None
 1.35A 5v3cA-2yvsA:
undetectable		 5v3cA-2yvsA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yvs GLYCOLATE OXIDASE
SUBUNIT GLCE
(Thermus
thermophilus) 		4 / 6 ARG A  49
GLN A 200
LEU A  39
PHE A  52
 None
 1.02A 5z84P-2yvsA:
undetectable
5z84W-2yvsA:
undetectable		 5z84P-2yvsA:
20.59
5z84W-2yvsA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yvs GLYCOLATE OXIDASE
SUBUNIT GLCE
(Thermus
thermophilus) 		4 / 7 ARG A  49
GLN A 200
LEU A  39
PHE A  52
 None
 0.95A 5z85C-2yvsA:
undetectable
5z85J-2yvsA:
undetectable		 5z85C-2yvsA:
20.59
5z85J-2yvsA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yvs GLYCOLATE OXIDASE
SUBUNIT GLCE
(Thermus
thermophilus) 		4 / 6 ARG A  49
GLN A 200
LEU A  39
PHE A  52
 None
 1.13A 5z85P-2yvsA:
undetectable
5z85W-2yvsA:
undetectable		 5z85P-2yvsA:
20.59
5z85W-2yvsA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yvs GLYCOLATE OXIDASE
SUBUNIT GLCE
(Thermus
thermophilus) 		4 / 6 ARG A  49
GLN A 200
LEU A  39
PHE A  52
 None
 0.99A 5z86C-2yvsA:
undetectable
5z86J-2yvsA:
undetectable		 5z86C-2yvsA:
20.59
5z86J-2yvsA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yvs GLYCOLATE OXIDASE
SUBUNIT GLCE
(Thermus
thermophilus) 		4 / 6 ARG A  49
GLN A 200
LEU A  39
PHE A  52
 None
 1.00A 5z86P-2yvsA:
undetectable
5z86W-2yvsA:
undetectable		 5z86P-2yvsA:
20.59
5z86W-2yvsA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yvs GLYCOLATE OXIDASE
SUBUNIT GLCE
(Thermus
thermophilus) 		4 / 6 ARG A  49
GLN A 200
LEU A  39
PHE A  52
 None
 0.94A 5zcoP-2yvsA:
undetectable
5zcoW-2yvsA:
undetectable		 5zcoP-2yvsA:
20.59
5zcoW-2yvsA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yvs GLYCOLATE OXIDASE
SUBUNIT GLCE
(Thermus
thermophilus) 		4 / 6 ARG A  49
GLN A 200
LEU A  39
PHE A  52
 None
 0.95A 5zcpC-2yvsA:
undetectable
5zcpJ-2yvsA:
undetectable		 5zcpC-2yvsA:
20.59
5zcpJ-2yvsA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yvs GLYCOLATE OXIDASE
SUBUNIT GLCE
(Thermus
thermophilus) 		4 / 6 ARG A  49
GLN A 200
LEU A  39
PHE A  52
 None
 1.01A 5zcpP-2yvsA:
undetectable
5zcpW-2yvsA:
undetectable		 5zcpP-2yvsA:
20.59
5zcpW-2yvsA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yvs GLYCOLATE OXIDASE
SUBUNIT GLCE
(Thermus
thermophilus) 		4 / 6 ARG A  49
GLN A 200
LEU A  39
PHE A  52
 None
 1.24A 6nmpC-2yvsA:
undetectable
6nmpJ-2yvsA:
undetectable		 6nmpC-2yvsA:
20.59
6nmpJ-2yvsA:
13.81