SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yvt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2yvt HYPOTHETICAL PROTEIN
AQ_1956
(Aquifex
aeolicus) 		4 / 7 PHE A 134
PHE A  93
VAL A  95
VAL A  37
 None
 0.90A 1epbA-2yvtA:
undetectable		 1epbA-2yvtA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 2yvt HYPOTHETICAL PROTEIN
AQ_1956
(Aquifex
aeolicus) 		5 / 9 GLY A 138
ILE A 179
PRO A 213
ILE A 208
ILE A 207
 None
 0.93A 1hshB-2yvtA:
undetectable		 1hshB-2yvtA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2yvt HYPOTHETICAL PROTEIN
AQ_1956
(Aquifex
aeolicus) 		4 / 7 ILE A 164
LEU A 165
THR A 144
LEU A 143
 None
 0.93A 1v55A-2yvtA:
undetectable
1v55J-2yvtA:
undetectable		 1v55A-2yvtA:
18.01
1v55J-2yvtA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B82_A_ADNA1001_1
(CLASS B ACID
PHOSPHATASE)		 2yvt HYPOTHETICAL PROTEIN
AQ_1956
(Aquifex
aeolicus) 		5 / 10 GLU A 150
TYR A 156
LEU A 154
GLY A  40
ASP A 100
 None
 1.46A 2b82A-2yvtA:
2.6		 2b82A-2yvtA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2yvt HYPOTHETICAL PROTEIN
AQ_1956
(Aquifex
aeolicus) 		4 / 6 GLU A  71
ASN A  45
PRO A 102
ALA A 101
 None
 1.31A 2ejfB-2yvtA:
undetectable		 2ejfB-2yvtA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2yvt HYPOTHETICAL PROTEIN
AQ_1956
(Aquifex
aeolicus) 		4 / 7 GLU A  71
ASN A  45
PRO A 102
ALA A 101
 None
 1.29A 2ejgA-2yvtA:
undetectable		 2ejgA-2yvtA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2yvt HYPOTHETICAL PROTEIN
AQ_1956
(Aquifex
aeolicus) 		4 / 7 GLU A  71
ASN A  45
PRO A 102
ALA A 101
 None
 1.25A 2ejgB-2yvtA:
undetectable		 2ejgB-2yvtA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 2yvt HYPOTHETICAL PROTEIN
AQ_1956
(Aquifex
aeolicus) 		5 / 11 LEU A 165
ILE A 208
THR A 231
ASN A 230
LEU A 123
 None
 1.23A 2ft9A-2yvtA:
undetectable		 2ft9A-2yvtA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 2yvt HYPOTHETICAL PROTEIN
AQ_1956
(Aquifex
aeolicus) 		4 / 8 VAL A 221
THR A 182
PRO A 183
SER A 201
 None
 0.96A 2v32C-2yvtA:
undetectable
2v32D-2yvtA:
undetectable		 2v32C-2yvtA:
25.27
2v32D-2yvtA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yvt HYPOTHETICAL PROTEIN
AQ_1956
(Aquifex
aeolicus) 		4 / 7 ILE A 164
LEU A 165
THR A 144
LEU A 143
 None
 0.94A 3ag3A-2yvtA:
undetectable
3ag3J-2yvtA:
undetectable		 3ag3A-2yvtA:
18.01
3ag3J-2yvtA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 2yvt HYPOTHETICAL PROTEIN
AQ_1956
(Aquifex
aeolicus) 		6 / 12 GLY A  97
GLY A  40
ASN A  13
ALA A 101
PHE A 180
LEU A 154
 None
 1.39A 3p2kC-2yvtA:
undetectable		 3p2kC-2yvtA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 2yvt HYPOTHETICAL PROTEIN
AQ_1956
(Aquifex
aeolicus) 		5 / 9 GLY A 138
ILE A 179
PRO A 213
ILE A 208
ILE A 207
 None
 0.94A 3s45A-2yvtA:
undetectable		 3s45A-2yvtA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 2yvt HYPOTHETICAL PROTEIN
AQ_1956
(Aquifex
aeolicus) 		5 / 12 GLY A 138
ILE A 179
PRO A 213
ILE A 208
ILE A 207
 None
 0.92A 3s54A-2yvtA:
undetectable		 3s54A-2yvtA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 2yvt HYPOTHETICAL PROTEIN
AQ_1956
(Aquifex
aeolicus) 		5 / 9 GLY A 138
ILE A 179
PRO A 213
ILE A 208
ILE A 207
 None
 1.12A 3s56B-2yvtA:
undetectable		 3s56B-2yvtA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2yvt HYPOTHETICAL PROTEIN
AQ_1956
(Aquifex
aeolicus) 		4 / 6 ASN A  99
GLU A 149
GLU A  49
GLU A  53
 None
 1.11A 4mi4A-2yvtA:
undetectable		 4mi4A-2yvtA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2yvt HYPOTHETICAL PROTEIN
AQ_1956
(Aquifex
aeolicus) 		4 / 7 ASN A  99
GLU A 149
GLU A  49
GLU A  53
 None
 1.11A 4mi4B-2yvtA:
2.0
4mi4C-2yvtA:
undetectable		 4mi4B-2yvtA:
23.22
4mi4C-2yvtA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2yvt HYPOTHETICAL PROTEIN
AQ_1956
(Aquifex
aeolicus) 		4 / 7 ASN A  99
GLU A 149
GLU A  49
GLU A  53
 None
 1.12A 4mi4A-2yvtA:
undetectable
4mi4C-2yvtA:
undetectable		 4mi4A-2yvtA:
23.22
4mi4C-2yvtA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2yvt HYPOTHETICAL PROTEIN
AQ_1956
(Aquifex
aeolicus) 		4 / 8 ASN A  99
GLU A 149
GLU A  49
GLU A  53
 None
 1.11A 4mj8A-2yvtA:
2.2
4mj8C-2yvtA:
2.1		 4mj8A-2yvtA:
23.60
4mj8C-2yvtA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2yvt HYPOTHETICAL PROTEIN
AQ_1956
(Aquifex
aeolicus) 		4 / 8 ASN A  99
GLU A 149
GLU A  49
GLU A  53
 None
 1.10A 4mj8B-2yvtA:
undetectable
4mj8C-2yvtA:
2.0		 4mj8B-2yvtA:
23.60
4mj8C-2yvtA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2yvt HYPOTHETICAL PROTEIN
AQ_1956
(Aquifex
aeolicus) 		4 / 7 ASN A  99
GLU A 149
GLU A  49
GLU A  53
 None
 1.11A 4mj8C-2yvtA:
2.1		 4mj8C-2yvtA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 2yvt HYPOTHETICAL PROTEIN
AQ_1956
(Aquifex
aeolicus) 		4 / 5 LEU A   9
VAL A 234
VAL A  39
TYR A 244
 None
 1.03A 4r7iA-2yvtA:
undetectable		 4r7iA-2yvtA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yvt HYPOTHETICAL PROTEIN
AQ_1956
(Aquifex
aeolicus) 		4 / 7 ILE A 164
LEU A 165
THR A 144
LEU A 143
 None
 0.91A 5b1aA-2yvtA:
undetectable
5b1aJ-2yvtA:
undetectable		 5b1aA-2yvtA:
18.01
5b1aJ-2yvtA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)		 2yvt HYPOTHETICAL PROTEIN
AQ_1956
(Aquifex
aeolicus) 		5 / 12 GLY A 138
ILE A 179
PRO A 213
ILE A 208
ILE A 207
 None
 0.86A 5e5jB-2yvtA:
undetectable		 5e5jB-2yvtA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2yvt HYPOTHETICAL PROTEIN
AQ_1956
(Aquifex
aeolicus) 		4 / 7 ILE A 164
LEU A 165
THR A 144
LEU A 143
 None
 0.93A 5xdxA-2yvtA:
undetectable
5xdxJ-2yvtA:
undetectable		 5xdxA-2yvtA:
18.01
5xdxJ-2yvtA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 2yvt HYPOTHETICAL PROTEIN
AQ_1956
(Aquifex
aeolicus) 		5 / 12 GLU A 238
LEU A  36
LEU A  24
LEU A   9
GLY A 219
 None
 1.00A 6b0cD-2yvtA:
undetectable		 6b0cD-2yvtA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 2yvt HYPOTHETICAL PROTEIN
AQ_1956
(Aquifex
aeolicus) 		5 / 10 LEU A 165
VAL A 168
THR A 231
ALA A 216
LEU A 176
 None
 1.07A 6h1lA-2yvtA:
undetectable		 6h1lA-2yvtA:
21.66