SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yvx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 2yvx MG2+ TRANSPORTER
MGTE
(Thermus
thermophilus) 		4 / 5 VAL A 375
GLY A 376
VAL A 378
TRP A 380
 None
 0.78A 1tkqB-2yvxA:
undetectable		 1tkqB-2yvxA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 2yvx MG2+ TRANSPORTER
MGTE
(Thermus
thermophilus) 		5 / 12 LEU A 394
GLY A 325
ASP A 432
GLY A 331
ILE A 397
 None
 0.96A 2f8gA-2yvxA:
undetectable		 2f8gA-2yvxA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2yvx MG2+ TRANSPORTER
MGTE
(Thermus
thermophilus) 		4 / 5 SER A 371
VAL A 375
SER A 393
VAL A 395
 None
 1.37A 2j9cA-2yvxA:
undetectable
2j9cB-2yvxA:
undetectable
2j9cC-2yvxA:
undetectable		 2j9cA-2yvxA:
14.74
2j9cB-2yvxA:
14.74
2j9cC-2yvxA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2yvx MG2+ TRANSPORTER
MGTE
(Thermus
thermophilus) 		4 / 6 LEU A 366
ALA A 401
LEU A 403
ALA A 406
 None
 0.94A 2vcvB-2yvxA:
undetectable		 2vcvB-2yvxA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2yvx MG2+ TRANSPORTER
MGTE
(Thermus
thermophilus) 		4 / 6 LEU A 366
ALA A 401
LEU A 403
ALA A 406
 None
 0.89A 2vcvK-2yvxA:
undetectable		 2vcvK-2yvxA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 2yvx MG2+ TRANSPORTER
MGTE
(Thermus
thermophilus) 		4 / 6 LEU A 430
ALA A 428
LEU A 426
SER A 423
 None
 1.05A 3cfqA-2yvxA:
undetectable		 3cfqA-2yvxA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 2yvx MG2+ TRANSPORTER
MGTE
(Thermus
thermophilus) 		5 / 11 LEU A 394
GLY A 325
ASP A 432
GLY A 331
ILE A 397
 None
 0.96A 3el1A-2yvxA:
undetectable		 3el1A-2yvxA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2yvx MG2+ TRANSPORTER
MGTE
(Thermus
thermophilus) 		3 / 3 ASP A 224
ARG A 220
ALA A 223
 None
None
MG  A 453 (-4.7A)
 0.72A 3mbgC-2yvxA:
2.1		 3mbgC-2yvxA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)		 2yvx MG2+ TRANSPORTER
MGTE
(Thermus
thermophilus) 		4 / 5 ARG A 413
ASP A 259
ASP A 418
ARG A 220
 None
MG  A 451 (-2.0A)
MG  A 451 (-3.4A)
None
 1.34A 3naiC-2yvxA:
1.0		 3naiC-2yvxA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 2yvx MG2+ TRANSPORTER
MGTE
(Thermus
thermophilus) 		4 / 7 ASP A 348
ASP A 351
VAL A 355
ILE A 339
 None
 0.68A 3t3cA-2yvxA:
undetectable		 3t3cA-2yvxA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 2yvx MG2+ TRANSPORTER
MGTE
(Thermus
thermophilus) 		4 / 5 LEU A 374
PRO A 321
VAL A 322
ASP A 381
 None
 1.11A 3ufnA-2yvxA:
undetectable
3ufnB-2yvxA:
undetectable		 3ufnA-2yvxA:
15.18
3ufnB-2yvxA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 2yvx MG2+ TRANSPORTER
MGTE
(Thermus
thermophilus) 		4 / 6 GLN A 215
ASP A  95
GLN A  98
GLU A 141
 None
 1.39A 4azvA-2yvxA:
undetectable		 4azvA-2yvxA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 2yvx MG2+ TRANSPORTER
MGTE
(Thermus
thermophilus) 		4 / 7 LEU A 408
THR A 434
THR A 429
VAL A 433
 None
 1.00A 4ik7A-2yvxA:
undetectable		 4ik7A-2yvxA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2yvx MG2+ TRANSPORTER
MGTE
(Thermus
thermophilus) 		4 / 8 TYR A 142
VAL A 232
LEU A  90
LEU A 126
 None
 0.81A 4jtrA-2yvxA:
undetectable		 4jtrA-2yvxA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 2yvx MG2+ TRANSPORTER
MGTE
(Thermus
thermophilus) 		3 / 3 TYR A 170
ARG A 187
SER A 185
 None
 1.02A 4khpI-2yvxA:
undetectable
4khpJ-2yvxA:
undetectable		 4khpI-2yvxA:
14.35
4khpJ-2yvxA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2yvx MG2+ TRANSPORTER
MGTE
(Thermus
thermophilus) 		5 / 8 VAL A 174
LEU A 180
LEU A 239
TYR A 142
ILE A 171
 None
 1.39A 4lzrA-2yvxA:
undetectable		 4lzrA-2yvxA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2yvx MG2+ TRANSPORTER
MGTE
(Thermus
thermophilus) 		5 / 12 ILE A 171
VAL A 145
LEU A 184
LEU A 155
LEU A 158
 None
 1.01A 4m11B-2yvxA:
undetectable		 4m11B-2yvxA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2yvx MG2+ TRANSPORTER
MGTE
(Thermus
thermophilus) 		4 / 5 GLU A 131
TYR A 129
GLU A 130
GLU A 133
 None
 1.37A 4r87E-2yvxA:
undetectable		 4r87E-2yvxA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2yvx MG2+ TRANSPORTER
MGTE
(Thermus
thermophilus) 		4 / 6 GLU A 131
TYR A 129
GLU A 130
GLU A 133
 None
 1.39A 4r87H-2yvxA:
undetectable		 4r87H-2yvxA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 2yvx MG2+ TRANSPORTER
MGTE
(Thermus
thermophilus) 		4 / 5 LEU A 189
ASP A 188
LEU A 155
THR A 196
 None
 1.27A 4wozF-2yvxA:
undetectable
4wozH-2yvxA:
undetectable		 4wozF-2yvxA:
21.01
4wozH-2yvxA:
21.01