SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yw4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 2yw4 4-HYDROXY-2-OXOGLUTA
RATE
ALDOLASE/2-DEYDRO-3-
DEOXYPHOSPHOGLUCONAT
E ALDOLASE
(Thermus
thermophilus) 		4 / 7 LEU A  34
LEU A  64
GLY A  62
LEU A  58
 None
 0.86A 1gtiB-2yw4A:
undetectable		 1gtiB-2yw4A:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 2yw4 4-HYDROXY-2-OXOGLUTA
RATE
ALDOLASE/2-DEYDRO-3-
DEOXYPHOSPHOGLUCONAT
E ALDOLASE
(Thermus
thermophilus) 		5 / 9 GLU A 134
LEU A 165
ALA A 169
LEU A 201
LEU A 174
 None
 1.42A 1hwiA-2yw4A:
undetectable		 1hwiA-2yw4A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 2yw4 4-HYDROXY-2-OXOGLUTA
RATE
ALDOLASE/2-DEYDRO-3-
DEOXYPHOSPHOGLUCONAT
E ALDOLASE
(Thermus
thermophilus) 		5 / 10 GLU A  43
ALA A  79
LEU A  55
ALA A  84
PHE A  86
 None
 1.20A 1mjqG-2yw4A:
undetectable
1mjqH-2yw4A:
undetectable		 1mjqG-2yw4A:
18.84
1mjqH-2yw4A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2yw4 4-HYDROXY-2-OXOGLUTA
RATE
ALDOLASE/2-DEYDRO-3-
DEOXYPHOSPHOGLUCONAT
E ALDOLASE
(Thermus
thermophilus) 		3 / 3 ARG A 143
VAL A 177
GLY A 159
 None
 0.61A 2avvE-2yw4A:
undetectable		 2avvE-2yw4A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2yw4 4-HYDROXY-2-OXOGLUTA
RATE
ALDOLASE/2-DEYDRO-3-
DEOXYPHOSPHOGLUCONAT
E ALDOLASE
(Thermus
thermophilus) 		3 / 3 LYS A 129
ARG A  47
LEU A  18
 None
 1.39A 3v4tE-2yw4A:
undetectable		 3v4tE-2yw4A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 2yw4 4-HYDROXY-2-OXOGLUTA
RATE
ALDOLASE/2-DEYDRO-3-
DEOXYPHOSPHOGLUCONAT
E ALDOLASE
(Thermus
thermophilus) 		4 / 8 LEU A  55
LEU A  52
GLY A  51
THR A  48
 None
 0.80A 4c9nA-2yw4A:
undetectable		 4c9nA-2yw4A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 2yw4 4-HYDROXY-2-OXOGLUTA
RATE
ALDOLASE/2-DEYDRO-3-
DEOXYPHOSPHOGLUCONAT
E ALDOLASE
(Thermus
thermophilus) 		5 / 11 LEU A  55
LEU A  46
LEU A 155
LEU A  64
LEU A  10
 None
 1.04A 4zowA-2yw4A:
undetectable		 4zowA-2yw4A:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 2yw4 4-HYDROXY-2-OXOGLUTA
RATE
ALDOLASE/2-DEYDRO-3-
DEOXYPHOSPHOGLUCONAT
E ALDOLASE
(Thermus
thermophilus) 		6 / 12 LEU A  87
VAL A  70
LEU A  52
LEU A  80
LEU A  55
GLY A  51
 None
 1.39A 5h2uA-2yw4A:
undetectable		 5h2uA-2yw4A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2yw4 4-HYDROXY-2-OXOGLUTA
RATE
ALDOLASE/2-DEYDRO-3-
DEOXYPHOSPHOGLUCONAT
E ALDOLASE
(Thermus
thermophilus) 		5 / 12 ALA A 197
LEU A 200
PRO A 166
ILE A 160
LEU A 171
 None
 1.26A 5ljcA-2yw4A:
undetectable		 5ljcA-2yw4A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 2yw4 4-HYDROXY-2-OXOGLUTA
RATE
ALDOLASE/2-DEYDRO-3-
DEOXYPHOSPHOGLUCONAT
E ALDOLASE
(Thermus
thermophilus) 		4 / 6 THR A  48
ARG A  22
ILE A  44
GLU A  43
 None
 1.28A 5uigA-2yw4A:
undetectable		 5uigA-2yw4A:
17.79