SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yw9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 2yw9 ENOYL-[ACYL CARRIER
PROTEIN] REDUCTASE
(Thermus
thermophilus) 		5 / 12 ARG A 184
GLY A 182
GLY A 179
ILE A 142
LEU A 229
 None
 0.98A 1p91B-2yw9A:
4.5		 1p91B-2yw9A:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2yw9 ENOYL-[ACYL CARRIER
PROTEIN] REDUCTASE
(Thermus
thermophilus) 		4 / 6 ILE A 254
GLY A 251
ALA A 250
HIS A 253
 None
 0.87A 1wmqA-2yw9A:
undetectable		 1wmqA-2yw9A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2yw9 ENOYL-[ACYL CARRIER
PROTEIN] REDUCTASE
(Thermus
thermophilus) 		4 / 6 ILE A 254
GLY A 251
ALA A 250
HIS A 253
 None
 0.86A 1wmqB-2yw9A:
undetectable		 1wmqB-2yw9A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2yw9 ENOYL-[ACYL CARRIER
PROTEIN] REDUCTASE
(Thermus
thermophilus) 		4 / 6 ILE A 254
GLY A 251
ALA A 250
HIS A 253
 None
 0.85A 1wpuA-2yw9A:
undetectable		 1wpuA-2yw9A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2yw9 ENOYL-[ACYL CARRIER
PROTEIN] REDUCTASE
(Thermus
thermophilus) 		4 / 6 ILE A 254
GLY A 251
ALA A 250
HIS A 253
 None
 0.86A 1wpuB-2yw9A:
undetectable		 1wpuB-2yw9A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2yw9 ENOYL-[ACYL CARRIER
PROTEIN] REDUCTASE
(Thermus
thermophilus) 		4 / 6 ILE A 254
GLY A 251
ALA A 250
HIS A 253
 None
 0.86A 1wrqA-2yw9A:
undetectable		 1wrqA-2yw9A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2yw9 ENOYL-[ACYL CARRIER
PROTEIN] REDUCTASE
(Thermus
thermophilus) 		4 / 6 ILE A 254
GLY A 251
ALA A 250
HIS A 253
 None
 0.86A 1wrqB-2yw9A:
undetectable		 1wrqB-2yw9A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2yw9 ENOYL-[ACYL CARRIER
PROTEIN] REDUCTASE
(Thermus
thermophilus) 		5 / 12 VAL A 245
ALA A 190
LEU A  22
LEU A 229
VAL A 171
 None
 0.99A 3fc6C-2yw9A:
undetectable		 3fc6C-2yw9A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 2yw9 ENOYL-[ACYL CARRIER
PROTEIN] REDUCTASE
(Thermus
thermophilus) 		3 / 3 TYR A 123
ASP A  70
ASP A  66
 None
 0.80A 4a6eA-2yw9A:
5.5		 4a6eA-2yw9A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 2yw9 ENOYL-[ACYL CARRIER
PROTEIN] REDUCTASE
(Thermus
thermophilus) 		5 / 12 HIS A  92
LEU A  12
SER A  40
LEU A  73
PHE A  77
 None
 1.17A 4qdcA-2yw9A:
undetectable		 4qdcA-2yw9A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2yw9 ENOYL-[ACYL CARRIER
PROTEIN] REDUCTASE
(Thermus
thermophilus) 		5 / 12 GLY A 141
GLY A 139
GLY A 182
LEU A  90
LEU A 234
 None
 0.97A 5c0oH-2yw9A:
6.8		 5c0oH-2yw9A:
25.09