SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ywa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 2ywa HYPOTHETICAL PROTEIN
TTHA0048
(Thermus
thermophilus) 		5 / 12 LEU A 105
ALA A 104
PHE A  74
THR A  85
LEU A  81
 None
 1.18A 1og5A-2ywaA:
undetectable		 1og5A-2ywaA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2ywa HYPOTHETICAL PROTEIN
TTHA0048
(Thermus
thermophilus) 		5 / 8 LEU A  11
LEU A  15
TYR A  98
ASP A  25
ILE A  28
 None
 1.24A 4lzrA-2ywaA:
undetectable		 4lzrA-2ywaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 2ywa HYPOTHETICAL PROTEIN
TTHA0048
(Thermus
thermophilus) 		3 / 3 ARG A 107
ASP A  72
TRP A  75
 None
 0.95A 4xdqA-2ywaA:
undetectable		 4xdqA-2ywaA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 2ywa HYPOTHETICAL PROTEIN
TTHA0048
(Thermus
thermophilus) 		3 / 3 GLU A  32
TRP A  39
ASN A  83
 None
 1.07A 5dv4A-2ywaA:
undetectable		 5dv4A-2ywaA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 2ywa HYPOTHETICAL PROTEIN
TTHA0048
(Thermus
thermophilus) 		4 / 5 GLU A  91
ALA A  94
GLU A  95
GLU A  21
 None
 1.11A 5dwkC-2ywaA:
2.6		 5dwkC-2ywaA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 2ywa HYPOTHETICAL PROTEIN
TTHA0048
(Thermus
thermophilus) 		4 / 5 LEU A  42
PHE A 108
LEU A   4
TRP A  75
 None
 1.46A 5m10A-2ywaA:
undetectable		 5m10A-2ywaA:
12.38