SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ywd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		6 / 12 VAL A 161
LEU A 160
LEU A 144
GLY A  79
ALA A  84
LEU A 103
 None
 1.23A 1cqeA-2ywdA:
undetectable		 1cqeA-2ywdA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		6 / 12 VAL A 161
LEU A 160
LEU A 144
GLY A  79
ALA A  84
LEU A 103
 None
 1.23A 1cqeB-2ywdA:
undetectable		 1cqeB-2ywdA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		4 / 6 VAL A  45
GLY A  79
LEU A  87
GLU A  63
 None
 1.04A 1fduD-2ywdA:
3.3		 1fduD-2ywdA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		5 / 10 HIS A  17
TYR A 184
LEU A 160
GLY A 129
PHE A 131
 None
 1.47A 1uhoA-2ywdA:
undetectable		 1uhoA-2ywdA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		6 / 12 VAL A 161
LEU A 160
LEU A 144
GLY A  79
ALA A  84
LEU A 103
 None
 1.27A 2aylA-2ywdA:
undetectable		 2aylA-2ywdA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		6 / 12 VAL A 161
LEU A 160
LEU A 144
PHE A 171
ALA A  84
LEU A 103
 None
 1.37A 2aylA-2ywdA:
undetectable		 2aylA-2ywdA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		6 / 12 VAL A 161
LEU A 160
LEU A 144
GLY A  79
ALA A  84
LEU A 103
 None
 1.20A 2aylB-2ywdA:
undetectable		 2aylB-2ywdA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		5 / 12 GLU A  19
ARG A  15
ALA A  28
ASP A  13
THR A 176
 None
 1.21A 2vdvE-2ywdA:
undetectable		 2vdvE-2ywdA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		5 / 11 GLU A  19
ARG A  15
ALA A  28
ASP A  13
THR A 176
 None
 1.20A 2vdvF-2ywdA:
undetectable		 2vdvF-2ywdA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		3 / 3 LYS A  29
LYS A  33
VAL A  31
 None
 1.09A 3brfA-2ywdA:
undetectable		 3brfA-2ywdA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		4 / 8 PHE A 185
GLY A  54
SER A  50
ILE A  53
 None
 0.89A 3ihzB-2ywdA:
undetectable		 3ihzB-2ywdA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		5 / 12 VAL A 161
LEU A 160
LEU A 144
GLY A  79
ALA A  84
 None
 1.10A 3kk6A-2ywdA:
undetectable		 3kk6A-2ywdA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		4 / 6 HIS A  36
VAL A  66
LEU A  21
LEU A  77
 None
 0.99A 3kk6A-2ywdA:
undetectable		 3kk6A-2ywdA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		5 / 12 VAL A 102
LEU A 103
LEU A 100
SER A 169
GLY A 164
 None
 1.22A 3kk6B-2ywdA:
undetectable		 3kk6B-2ywdA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		6 / 12 VAL A 107
VAL A 161
LEU A 160
GLY A  79
ALA A  84
LEU A 103
 None
 1.34A 3n8wA-2ywdA:
undetectable		 3n8wA-2ywdA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		6 / 12 VAL A 161
LEU A 160
LEU A 144
GLY A  79
ALA A  84
LEU A 103
 None
 1.19A 3n8wA-2ywdA:
undetectable		 3n8wA-2ywdA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		5 / 12 VAL A 107
VAL A 161
LEU A 160
GLY A  79
ALA A  84
 None
 1.07A 3n8zA-2ywdA:
undetectable		 3n8zA-2ywdA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		5 / 12 VAL A 161
LEU A 160
LEU A 144
GLY A  79
LEU A 103
 None
 1.02A 3n8zA-2ywdA:
undetectable		 3n8zA-2ywdA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		5 / 11 VAL A 161
LEU A 160
LEU A 144
GLY A  79
ALA A  84
 None
 1.08A 3pghB-2ywdA:
undetectable		 3pghB-2ywdA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		6 / 12 VAL A  31
VAL A  66
LEU A  37
GLY A  54
ALA A  57
LEU A   8
 None
 1.47A 3pghC-2ywdA:
undetectable		 3pghC-2ywdA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		6 / 12 VAL A 161
LEU A 160
LEU A 144
GLY A  79
ALA A  84
LEU A 103
 None
 1.13A 3pghC-2ywdA:
undetectable		 3pghC-2ywdA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		6 / 12 VAL A 161
LEU A 160
LEU A 144
GLY A  79
ALA A  84
LEU A 103
 None
 1.13A 3pghD-2ywdA:
undetectable		 3pghD-2ywdA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		5 / 12 PRO A  46
GLY A  47
GLY A  48
LEU A 167
LEU A 103
 None
 1.04A 4fp9A-2ywdA:
undetectable		 4fp9A-2ywdA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		5 / 12 PRO A  46
GLY A  47
GLY A  48
LEU A 167
LEU A 103
 None
 1.04A 4fp9C-2ywdA:
undetectable		 4fp9C-2ywdA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		5 / 12 PRO A  46
GLY A  47
GLY A  48
LEU A 167
LEU A 103
 None
 1.05A 4fp9D-2ywdA:
undetectable		 4fp9D-2ywdA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		5 / 12 PRO A  46
GLY A  47
GLY A  48
LEU A 167
LEU A 103
 None
 1.05A 4fp9F-2ywdA:
undetectable		 4fp9F-2ywdA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		5 / 12 PRO A  46
GLY A  47
GLY A  48
LEU A 167
LEU A 103
 None
 0.98A 4fzvA-2ywdA:
undetectable		 4fzvA-2ywdA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		5 / 12 LEU A 103
GLU A 149
VAL A 161
ARG A 162
GLY A 190
 None
 1.10A 4q15A-2ywdA:
undetectable		 4q15A-2ywdA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		5 / 12 LEU A 103
GLU A 149
VAL A 161
ARG A 162
GLY A 190
 None
 1.12A 4q15B-2ywdA:
2.4		 4q15B-2ywdA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		6 / 9 VAL A 161
LEU A 160
LEU A 144
GLY A  79
ALA A  84
LEU A 103
 None
 1.14A 4rs0A-2ywdA:
undetectable		 4rs0A-2ywdA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		5 / 12 LEU A 103
GLU A 149
VAL A 161
ARG A 162
GLY A 190
 None
 1.11A 4ydqA-2ywdA:
2.2		 4ydqA-2ywdA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		5 / 12 LEU A 103
GLU A 149
VAL A 161
ARG A 162
GLY A 190
 None
 1.12A 5f9zA-2ywdA:
undetectable		 5f9zA-2ywdA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		5 / 12 LEU A 103
GLU A 149
VAL A 161
ARG A 162
GLY A 190
 None
 1.14A 5f9zB-2ywdA:
2.2		 5f9zB-2ywdA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		6 / 12 VAL A 161
LEU A 160
LEU A 144
GLY A  79
ALA A  84
LEU A 103
 None
 1.25A 5ikrB-2ywdA:
undetectable		 5ikrB-2ywdA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		5 / 12 LEU A 160
LEU A 144
GLY A  79
ALA A  84
LEU A 103
 None
 1.09A 5jw1B-2ywdA:
undetectable		 5jw1B-2ywdA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		4 / 5 ILE A  85
PHE A 141
SER A 169
ALA A  88
 None
 1.23A 5msdA-2ywdA:
undetectable		 5msdA-2ywdA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		5 / 12 LEU A 103
GLU A 149
VAL A 161
ARG A 162
GLY A 190
 None
 1.12A 5xipA-2ywdA:
undetectable		 5xipA-2ywdA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		5 / 12 LEU A 103
GLU A 149
VAL A 161
ARG A 162
GLY A 190
 None
 1.08A 5xiqD-2ywdA:
2.1		 5xiqD-2ywdA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT
(Thermus
thermophilus) 		4 / 8 LEU A  43
LEU A  37
GLY A  54
ARG A  58
 None
 0.87A 6ce2A-2ywdA:
undetectable		 6ce2A-2ywdA:
17.39