SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ywg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ywg GTP-BINDING PROTEIN
LEPA
(Aquifex
aeolicus) 		5 / 12 THR A  30
PHE A  64
PHE A   9
VAL A 257
ALA A 241
 None
 1.40A 1q23D-2ywgA:
undetectable
1q23E-2ywgA:
undetectable		 1q23D-2ywgA:
16.36
1q23E-2ywgA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 2ywg GTP-BINDING PROTEIN
LEPA
(Aquifex
aeolicus) 		5 / 12 VAL A 131
LEU A  26
GLY A 170
ALA A 163
LEU A 103
 None
 1.00A 1r9oA-2ywgA:
undetectable		 1r9oA-2ywgA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 2ywg GTP-BINDING PROTEIN
LEPA
(Aquifex
aeolicus) 		4 / 6 LEU A 126
ALA A  96
LEU A  94
VAL A 257
 None
 1.16A 1sn5A-2ywgA:
undetectable		 1sn5A-2ywgA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 2ywg GTP-BINDING PROTEIN
LEPA
(Aquifex
aeolicus) 		5 / 12 TYR A 201
ALA A 195
GLY A 240
GLY A 258
ILE A 214
 None
 1.13A 1x1aA-2ywgA:
undetectable		 1x1aA-2ywgA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 2ywg GTP-BINDING PROTEIN
LEPA
(Aquifex
aeolicus) 		5 / 10 PHE A 118
LEU A 439
GLU A 447
LEU A 153
VAL A 152
 None
 1.23A 2bxeA-2ywgA:
undetectable		 2bxeA-2ywgA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2ywg GTP-BINDING PROTEIN
LEPA
(Aquifex
aeolicus) 		4 / 6 ARG A 144
GLU A 150
PRO A 157
ALA A 160
 None
 1.37A 2ejfB-2ywgA:
undetectable		 2ejfB-2ywgA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2ywg GTP-BINDING PROTEIN
LEPA
(Aquifex
aeolicus) 		3 / 3 ARG A 356
GLU A 360
SER A  20
 None
None
GTP  A 701 (-2.6A)
 0.84A 2xctD-2ywgA:
4.4		 2xctD-2ywgA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2ywg GTP-BINDING PROTEIN
LEPA
(Aquifex
aeolicus) 		4 / 8 GLN A 113
HIS A  83
VAL A 408
VAL A 410
 None
 0.74A 3fi0Q-2ywgA:
undetectable		 3fi0Q-2ywgA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2ywg GTP-BINDING PROTEIN
LEPA
(Aquifex
aeolicus) 		4 / 6 VAL A 131
ILE A 171
ILE A 161
LEU A 162
 None
 0.68A 3hegA-2ywgA:
undetectable		 3hegA-2ywgA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 2ywg GTP-BINDING PROTEIN
LEPA
(Aquifex
aeolicus) 		5 / 12 LEU A 425
CYH A 426
ILE A 455
ILE A 466
VAL A  84
 None
 1.14A 3vw1D-2ywgA:
undetectable		 3vw1D-2ywgA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 2ywg GTP-BINDING PROTEIN
LEPA
(Aquifex
aeolicus) 		4 / 8 LEU A 425
CYH A 426
TYR A 448
PRO A 421
 None
 1.12A 4j7uD-2ywgA:
2.4		 4j7uD-2ywgA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 2ywg GTP-BINDING PROTEIN
LEPA
(Aquifex
aeolicus) 		5 / 9 ASP A 323
ALA A 325
VAL A 327
GLY A 346
ILE A 326
 None
 1.22A 4ll3B-2ywgA:
undetectable		 4ll3B-2ywgA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2ywg GTP-BINDING PROTEIN
LEPA
(Aquifex
aeolicus) 		4 / 6 SER A 333
GLU A 331
VAL A 490
THR A 489
 None
 1.33A 4lnxA-2ywgA:
undetectable		 4lnxA-2ywgA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 2ywg GTP-BINDING PROTEIN
LEPA
(Aquifex
aeolicus) 		3 / 3 PRO A 185
ASN A   8
HIS A  76
 None
 0.92A 4ma3H-2ywgA:
2.4
4ma3L-2ywgA:
2.4		 4ma3H-2ywgA:
14.81
4ma3L-2ywgA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 2ywg GTP-BINDING PROTEIN
LEPA
(Aquifex
aeolicus) 		4 / 6 PHE A  86
HIS A 349
ILE A 352
TYR A 319
 None
 1.24A 4o7gB-2ywgA:
undetectable		 4o7gB-2ywgA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		 2ywg GTP-BINDING PROTEIN
LEPA
(Aquifex
aeolicus) 		5 / 12 ALA A 299
ARG A 388
ILE A 373
ILE A 456
TYR A 374
 None
 1.44A 4qe6A-2ywgA:
0.0		 4qe6A-2ywgA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2ywg GTP-BINDING PROTEIN
LEPA
(Aquifex
aeolicus) 		5 / 10 ARG A 213
ILE A  78
ALA A  96
LEU A 196
ALA A 195
 None
 1.39A 4xk8B-2ywgA:
undetectable		 4xk8B-2ywgA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ywg GTP-BINDING PROTEIN
LEPA
(Aquifex
aeolicus) 		4 / 4 ALA A 195
PRO A 185
LEU A  75
HIS A  76
 None
 1.38A 5eskA-2ywgA:
undetectable		 5eskA-2ywgA:
22.12