SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ywi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 2ywi HYPOTHETICAL
CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		5 / 12 THR A 129
ILE A 163
TYR A 112
ILE A  31
ALA A 103
 None
 1.22A 1jtxA-2ywiA:
undetectable		 1jtxA-2ywiA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUF_B_AZ1B503_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 2ywi HYPOTHETICAL
CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		4 / 6 SER A  13
ARG A 144
TYR A 143
TYR A 133
 None
 1.47A 1tufA-2ywiA:
undetectable
1tufB-2ywiA:
undetectable		 1tufA-2ywiA:
17.74
1tufB-2ywiA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_B_CHDB1_0
(FERROCHELATASE)		 2ywi HYPOTHETICAL
CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		5 / 10 LEU A  66
LYS A 189
PRO A 152
SER A 150
GLY A 185
 None
 1.46A 2qd2B-2ywiA:
1.1		 2qd2B-2ywiA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ywi HYPOTHETICAL
CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		4 / 7 LEU A  66
PRO A 152
SER A 150
GLY A 185
 None
 1.06A 3hcnA-2ywiA:
undetectable		 3hcnA-2ywiA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ywi HYPOTHETICAL
CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		4 / 7 LEU A  66
PRO A 152
SER A 150
GLY A 185
 None
 1.05A 3hcrB-2ywiA:
undetectable		 3hcrB-2ywiA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 2ywi HYPOTHETICAL
CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		5 / 11 TYR A 133
ASP A 131
GLU A 119
VAL A 120
ILE A  52
 None
 1.34A 4drjA-2ywiA:
undetectable		 4drjA-2ywiA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2ywi HYPOTHETICAL
CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		4 / 5 TYR A 143
GLN A 146
GLY A 145
SER A  13
 None
 1.18A 4fu8A-2ywiA:
undetectable		 4fu8A-2ywiA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ywi HYPOTHETICAL
CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		4 / 5 ALA A 126
TYR A 124
PRO A  17
PHE A 135
 None
 1.21A 4ze2A-2ywiA:
undetectable		 4ze2A-2ywiA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 2ywi HYPOTHETICAL
CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		4 / 6 ILE A  49
TYR A 133
PHE A 132
TRP A 190
 None
 1.37A 5g08A-2ywiA:
undetectable		 5g08A-2ywiA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 2ywi HYPOTHETICAL
CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		3 / 3 GLU A  12
ASP A 131
PRO A 130
 None
 0.78A 6berA-2ywiA:
undetectable		 6berA-2ywiA:
8.05