SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ywo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ywo PROBABLE
THIOL-DISULFIDE
ISOMERASE/THIOREDOXI
N
(Thermus
thermophilus) 		5 / 10 SER A  11
PHE A 121
VAL A 108
PHE A  40
VAL A  38
 None
 1.47A 1q23E-2ywoA:
undetectable		 1q23E-2ywoA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ywo PROBABLE
THIOL-DISULFIDE
ISOMERASE/THIOREDOXI
N
(Thermus
thermophilus) 		5 / 10 SER A  11
PHE A 121
VAL A 108
PHE A  40
VAL A  38
 None
 1.48A 1q23K-2ywoA:
undetectable		 1q23K-2ywoA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 2ywo PROBABLE
THIOL-DISULFIDE
ISOMERASE/THIOREDOXI
N
(Thermus
thermophilus) 		5 / 12 LEU A 122
LEU A 157
ARG A 159
LEU A 158
ALA A 152
 None
 1.00A 2bxqA-2ywoA:
undetectable		 2bxqA-2ywoA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 2ywo PROBABLE
THIOL-DISULFIDE
ISOMERASE/THIOREDOXI
N
(Thermus
thermophilus) 		4 / 4 LEU A 122
ARG A 159
LEU A 158
ALA A 152
 None
 1.00A 3b9mA-2ywoA:
undetectable		 3b9mA-2ywoA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 2ywo PROBABLE
THIOL-DISULFIDE
ISOMERASE/THIOREDOXI
N
(Thermus
thermophilus) 		5 / 12 THR A 174
GLN A 106
ALA A 109
ASN A  72
ILE A  71
 None
 1.14A 3ddyA-2ywoA:
undetectable		 3ddyA-2ywoA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 2ywo PROBABLE
THIOL-DISULFIDE
ISOMERASE/THIOREDOXI
N
(Thermus
thermophilus) 		3 / 3 GLU A 104
ASP A 103
ASP A  75
 None
 0.70A 3jb2A-2ywoA:
undetectable		 3jb2A-2ywoA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 2ywo PROBABLE
THIOL-DISULFIDE
ISOMERASE/THIOREDOXI
N
(Thermus
thermophilus) 		5 / 10 PHE A 121
PHE A 123
ALA A 111
ILE A  71
PHE A  40
 None
 1.42A 3t3qA-2ywoA:
undetectable		 3t3qA-2ywoA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 2ywo PROBABLE
THIOL-DISULFIDE
ISOMERASE/THIOREDOXI
N
(Thermus
thermophilus) 		5 / 10 PHE A 121
PHE A 123
ALA A 111
ILE A  71
PHE A  40
 None
 1.40A 3t3qD-2ywoA:
undetectable		 3t3qD-2ywoA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ywo PROBABLE
THIOL-DISULFIDE
ISOMERASE/THIOREDOXI
N
(Thermus
thermophilus) 		5 / 12 SER A  11
LEU A  28
PHE A  40
VAL A  38
ALA A 111
 None
 1.38A 3u9fD-2ywoA:
undetectable
3u9fE-2ywoA:
undetectable		 3u9fD-2ywoA:
21.86
3u9fE-2ywoA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ywo PROBABLE
THIOL-DISULFIDE
ISOMERASE/THIOREDOXI
N
(Thermus
thermophilus) 		5 / 10 SER A  11
PHE A 121
LEU A  28
PHE A  40
VAL A  38
 None
 1.37A 3u9fR-2ywoA:
undetectable		 3u9fR-2ywoA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2ywo PROBABLE
THIOL-DISULFIDE
ISOMERASE/THIOREDOXI
N
(Thermus
thermophilus) 		4 / 5 GLY A  23
ASP A  20
GLU A  17
VAL A 108
 None
 1.08A 4nkvD-2ywoA:
undetectable		 4nkvD-2ywoA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 2ywo PROBABLE
THIOL-DISULFIDE
ISOMERASE/THIOREDOXI
N
(Thermus
thermophilus) 		5 / 12 GLY A  53
LEU A  55
VAL A 135
VAL A  66
PHE A  68
 None
 1.13A 4wnwA-2ywoA:
undetectable		 4wnwA-2ywoA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ywo PROBABLE
THIOL-DISULFIDE
ISOMERASE/THIOREDOXI
N
(Thermus
thermophilus) 		4 / 5 ALA A 114
TYR A 112
PRO A   8
PHE A 123
 None
 1.15A 4ze2A-2ywoA:
undetectable		 4ze2A-2ywoA:
16.20