SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ywr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Aquifex
aeolicus) 		3 / 3 GLN A 180
ILE A 113
HIS A 109
 None
None
CO  A 704 (-3.3A)
 0.72A 1fm9A-2ywrA:
undetectable		 1fm9A-2ywrA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Aquifex
aeolicus) 		4 / 7 LEU A 166
ILE A 170
ILE A 113
PRO A 110
 None
 0.99A 1oniB-2ywrA:
undetectable
1oniC-2ywrA:
undetectable		 1oniB-2ywrA:
20.47
1oniC-2ywrA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 10 LEU A  86
VAL A 137
ILE A 150
ILE A 192
PHE A 185
 None
 0.87A 1q6iB-2ywrA:
undetectable		 1q6iB-2ywrA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Aquifex
aeolicus) 		4 / 6 LEU A  83
LEU A  15
LEU A 178
ILE A  19
 None
 1.01A 1z95A-2ywrA:
undetectable		 1z95A-2ywrA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Aquifex
aeolicus) 		3 / 3 ASP A  37
PHE A  68
ARG A  91
 None
 0.71A 2a3aA-2ywrA:
undetectable		 2a3aA-2ywrA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_E_SAME500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 11 SER A   9
GLY A  12
SER A  13
LEU A  86
ASP A  37
 None
MG  A 703 ( 3.9A)
MG  A 703 (-4.1A)
None
None
 1.45A 2c2bE-2ywrA:
0.7
2c2bF-2ywrA:
4.0		 2c2bE-2ywrA:
18.40
2c2bF-2ywrA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 LEU A 178
LEU A  15
ILE A  31
ILE A   4
ALA A  29
 None
 1.23A 2gj5A-2ywrA:
undetectable		 2gj5A-2ywrA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 LEU A  76
LEU A   7
SER A   9
ILE A  57
CYH A  54
 None
None
None
None
CO  A 767 (-3.6A)
 1.12A 2oipD-2ywrA:
undetectable		 2oipD-2ywrA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 11 LEU A  76
VAL A  81
GLY A  80
ILE A  35
GLU A  32
 None
None
None
None
CO  A 766 ( 4.9A)
 1.03A 2yy8A-2ywrA:
2.7
2yy8B-2ywrA:
undetectable		 2yy8A-2ywrA:
26.56
2yy8B-2ywrA:
26.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 ILE A  92
LEU A  93
LEU A  98
ASN A 107
VAL A 140
 None
None
None
CO  A 704 ( 4.4A)
None
 0.64A 3dcjA-2ywrA:
28.3
3dcjB-2ywrA:
29.0		 3dcjA-2ywrA:
33.92
3dcjB-2ywrA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 LEU A  93
LEU A  98
ASN A 107
PRO A 110
VAL A 140
 None
None
CO  A 704 ( 4.4A)
None
None
 0.68A 3dcjA-2ywrA:
28.3
3dcjB-2ywrA:
29.0		 3dcjA-2ywrA:
33.92
3dcjB-2ywrA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 MET A  90
ILE A  92
LEU A  93
LEU A  98
VAL A 140
 None
 0.86A 3dcjA-2ywrA:
28.3
3dcjB-2ywrA:
29.0		 3dcjA-2ywrA:
33.92
3dcjB-2ywrA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Aquifex
aeolicus) 		4 / 8 ILE A  92
LEU A  93
ASN A 107
VAL A 140
 None
None
CO  A 704 ( 4.4A)
None
 0.44A 3dcjB-2ywrA:
29.0		 3dcjB-2ywrA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Aquifex
aeolicus) 		4 / 8 LEU A  93
LEU A  98
ASN A 107
VAL A 140
 None
None
CO  A 704 ( 4.4A)
None
 0.47A 3dcjB-2ywrA:
29.0		 3dcjB-2ywrA:
33.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 ILE A  44
VAL A  52
ILE A   4
VAL A   6
VAL A   8
 CO  A 767 (-4.5A)
None
None
None
None
 1.22A 3iw1A-2ywrA:
undetectable		 3iw1A-2ywrA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 10 ASN A  38
ALA A  43
ASN A  14
LEU A  15
VAL A   8
 None
None
MG  A 703 (-4.0A)
None
None
 1.21A 3o02A-2ywrA:
undetectable
3o02B-2ywrA:
undetectable		 3o02A-2ywrA:
21.14
3o02B-2ywrA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Aquifex
aeolicus) 		3 / 3 HIS A 109
HIS A 138
ILE A 113
 CO  A 704 (-3.3A)
None
None
 0.75A 3u52A-2ywrA:
undetectable
3u52C-2ywrA:
undetectable		 3u52A-2ywrA:
16.99
3u52C-2ywrA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Aquifex
aeolicus) 		4 / 8 VAL A 137
ILE A 150
ILE A 192
PHE A 185
 None
 0.75A 3uqbA-2ywrA:
undetectable		 3uqbA-2ywrA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 ILE A  31
ILE A   4
ALA A  29
ALA A  21
LEU A 178
 None
 1.07A 3uvvA-2ywrA:
undetectable		 3uvvA-2ywrA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 ILE A  31
GLY A   5
ILE A 106
VAL A 137
LEU A   2
 None
 1.16A 4a81A-2ywrA:
undetectable		 4a81A-2ywrA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 LEU A  15
VAL A   6
LEU A   2
ILE A  31
ILE A  19
 None
 0.98A 4ltwA-2ywrA:
undetectable		 4ltwA-2ywrA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 VAL A 137
ARG A 195
ILE A 192
PHE A 185
PRO A 114
 None
 1.23A 4nnrA-2ywrA:
undetectable
4nnrB-2ywrA:
undetectable		 4nnrA-2ywrA:
22.22
4nnrB-2ywrA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Aquifex
aeolicus) 		4 / 5 ILE A  35
LYS A   3
ILE A   4
VAL A  84
 None
 0.96A 5jmnA-2ywrA:
undetectable		 5jmnA-2ywrA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Aquifex
aeolicus) 		4 / 7 ILE A 150
VAL A 151
TYR A 204
GLN A 180
 None
 1.28A 5kkzM-2ywrA:
undetectable
5kkzO-2ywrA:
undetectable		 5kkzM-2ywrA:
22.67
5kkzO-2ywrA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Aquifex
aeolicus) 		4 / 6 LEU A   7
LYS A  65
GLU A  69
LEU A  93
 None
 1.45A 5xooA-2ywrA:
undetectable		 5xooA-2ywrA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Aquifex
aeolicus) 		4 / 5 PRO A 211
VAL A 199
GLY A 147
VAL A 137
 None
 1.06A 6ak3B-2ywrA:
undetectable		 6ak3B-2ywrA:
16.20