SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ywx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 2ywx PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 130
ILE A  58
ILE A  56
VAL A  54
ILE A 117
 None
 1.35A 1r5lA-2ywxA:
undetectable		 1r5lA-2ywxA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 2ywx PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 104
ILE A 122
PRO A  76
PHE A  55
THR A  73
 None
 1.26A 3bjwF-2ywxA:
undetectable		 3bjwF-2ywxA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2ywx PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  22
VAL A  80
ILE A 122
LEU A 118
VAL A 107
 None
 1.18A 3w68C-2ywxA:
undetectable		 3w68C-2ywxA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 2ywx PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 9 ALA A 119
ALA A  18
GLY A 112
ILE A  58
ILE A   4
 None
 1.08A 4eatB-2ywxA:
4.1		 4eatB-2ywxA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 2ywx PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 7 ARG A 111
GLY A 112
ILE A  21
GLU A 113
 None
 0.88A 4g0vA-2ywxA:
undetectable		 4g0vA-2ywxA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2ywx PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  58
VAL A  77
PHE A  55
VAL A  54
VAL A  31
 None
 1.16A 5n0oA-2ywxA:
undetectable		 5n0oA-2ywxA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2ywx PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  58
VAL A  77
PHE A  55
VAL A  54
VAL A  31
 None
 1.13A 5n0rA-2ywxA:
undetectable		 5n0rA-2ywxA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2ywx PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  58
VAL A  77
PHE A  55
VAL A  54
VAL A  31
 None
 1.16A 5n0sB-2ywxA:
undetectable		 5n0sB-2ywxA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2ywx PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  58
VAL A  77
PHE A  55
VAL A  54
VAL A  31
 None
 1.16A 5n0wA-2ywxA:
undetectable		 5n0wA-2ywxA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 2ywx PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 8 ALA A  52
ILE A 122
ALA A 119
LEU A 123
 None
 0.77A 5te8B-2ywxA:
undetectable		 5te8B-2ywxA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 2ywx PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A 110
VAL A  80
ILE A  14
ILE A  21
VAL A 107
 None
 0.96A 6dh0A-2ywxA:
undetectable		 6dh0A-2ywxA:
19.11