SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yx0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 2yx0 RADICAL SAM ENZYME
(Pyrococcus
horikoshii) 		4 / 6 TRP A 222
GLY A 221
ASN A 214
PRO A 219
 None
 1.23A 1dedA-2yx0A:
undetectable		 1dedA-2yx0A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 2yx0 RADICAL SAM ENZYME
(Pyrococcus
horikoshii) 		4 / 7 MET A 251
SER A 291
ALA A 273
ILE A 295
 None
 1.07A 1fxhA-2yx0A:
undetectable
1fxhB-2yx0A:
undetectable		 1fxhA-2yx0A:
21.18
1fxhB-2yx0A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 2yx0 RADICAL SAM ENZYME
(Pyrococcus
horikoshii) 		5 / 11 VAL A 241
ILE A 202
LEU A 243
LEU A 306
LEU A 302
 None
 1.10A 2a15A-2yx0A:
undetectable		 2a15A-2yx0A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 2yx0 RADICAL SAM ENZYME
(Pyrococcus
horikoshii) 		4 / 8 ALA A 146
ILE A 147
PRO A 153
PRO A  76
 None
 0.86A 3fxrA-2yx0A:
0.6		 3fxrA-2yx0A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2yx0 RADICAL SAM ENZYME
(Pyrococcus
horikoshii) 		5 / 12 ALA A 264
LEU A 235
THR A 177
ILE A 175
LEU A 185
 None
 1.07A 3nrrA-2yx0A:
undetectable		 3nrrA-2yx0A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2yx0 RADICAL SAM ENZYME
(Pyrococcus
horikoshii) 		5 / 12 ALA A 264
LEU A 235
THR A 177
ILE A 175
LEU A 185
 None
 1.09A 3nrrB-2yx0A:
undetectable		 3nrrB-2yx0A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2yx0 RADICAL SAM ENZYME
(Pyrococcus
horikoshii) 		4 / 7 GLY A 179
THR A 180
ILE A 225
THR A 244
 None
 0.79A 4acaC-2yx0A:
2.8		 4acaC-2yx0A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 2yx0 RADICAL SAM ENZYME
(Pyrococcus
horikoshii) 		4 / 7 VAL A 240
GLN A 197
TYR A 199
LEU A 322
 None
 1.19A 4hxyB-2yx0A:
undetectable		 4hxyB-2yx0A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 2yx0 RADICAL SAM ENZYME
(Pyrococcus
horikoshii) 		5 / 12 MET A 159
LEU A 231
MET A 232
LEU A 235
ILE A 175
 None
 1.00A 4j24C-2yx0A:
undetectable		 4j24C-2yx0A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 2yx0 RADICAL SAM ENZYME
(Pyrococcus
horikoshii) 		5 / 12 GLU A 152
PHE A 228
LEU A 229
LEU A 260
ALA A 204
 None
 1.03A 4wcxC-2yx0A:
10.6		 4wcxC-2yx0A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_C_PACC601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 2yx0 RADICAL SAM ENZYME
(Pyrococcus
horikoshii) 		5 / 12 PRO A 142
PHE A 171
PHE A 166
ILE A 115
VAL A  42
 None
 1.24A 4yfbC-2yx0A:
undetectable		 4yfbC-2yx0A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_F_PACF601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 2yx0 RADICAL SAM ENZYME
(Pyrococcus
horikoshii) 		5 / 12 PRO A 142
PHE A 171
PHE A 166
ILE A 115
VAL A  42
 None
 1.24A 4yfbF-2yx0A:
undetectable		 4yfbF-2yx0A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 2yx0 RADICAL SAM ENZYME
(Pyrococcus
horikoshii) 		5 / 12 PRO A 142
PHE A 171
PHE A 166
ILE A 115
VAL A  42
 None
 1.23A 4yfbI-2yx0A:
undetectable		 4yfbI-2yx0A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_L_PACL601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 2yx0 RADICAL SAM ENZYME
(Pyrococcus
horikoshii) 		5 / 12 PRO A 142
PHE A 171
PHE A 166
ILE A 115
VAL A  42
 None
 1.23A 4yfbL-2yx0A:
undetectable		 4yfbL-2yx0A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 2yx0 RADICAL SAM ENZYME
(Pyrococcus
horikoshii) 		4 / 5 LYS A 263
ALA A 264
LEU A 231
VAL A 241
 None
 1.07A 5cr1A-2yx0A:
undetectable		 5cr1A-2yx0A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 2yx0 RADICAL SAM ENZYME
(Pyrococcus
horikoshii) 		4 / 6 GLN A  73
MET A 159
ARG A 169
PRO A 142
 None
 1.13A 6brdB-2yx0A:
undetectable		 6brdB-2yx0A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 2yx0 RADICAL SAM ENZYME
(Pyrococcus
horikoshii) 		3 / 3 GLU A  99
LEU A 155
ARG A 184
 None
 0.63A 6d8fA-2yx0A:
undetectable		 6d8fA-2yx0A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 2yx0 RADICAL SAM ENZYME
(Pyrococcus
horikoshii) 		3 / 3 TYR A 125
ALA A 139
LEU A  44
 None
 0.72A 6d9kF-2yx0A:
undetectable		 6d9kF-2yx0A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 2yx0 RADICAL SAM ENZYME
(Pyrococcus
horikoshii) 		4 / 5 LEU A 231
LEU A 198
THR A 180
PRO A  76
 None
 1.09A 6ew0F-2yx0A:
3.3		 6ew0F-2yx0A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 2yx0 RADICAL SAM ENZYME
(Pyrococcus
horikoshii) 		4 / 6 LEU A 231
LEU A 198
THR A 180
PRO A  76
 None
 1.09A 6ew0G-2yx0A:
3.0		 6ew0G-2yx0A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 2yx0 RADICAL SAM ENZYME
(Pyrococcus
horikoshii) 		4 / 7 ARG A 265
LEU A 243
TYR A 309
VAL A 241
 None
 1.27A 6g2pA-2yx0A:
undetectable		 6g2pA-2yx0A:
19.95