SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yx6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NNI_A_MTKA501_1 (CYTOCHROME P450 2C8)	2yx6	HYPOTHETICAL PROTEIN PH0822 (Pyrococcus horikoshii)	5 / 12	SER A 24 SER A 18 VAL A 98 VAL A 28 VAL A 3	None	1.27A	2nniA-2yx6A: undetectable	2nniA-2yx6A: 12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VCV_A_ASDA1224_1 (GLUTATHIONE S-TRANSFERASE A3)	2yx6	HYPOTHETICAL PROTEIN PH0822 (Pyrococcus horikoshii)	4 / 7	PRO A 56 ALA A 76 LEU A 55 PHE A 27	None	1.15A	2vcvA-2yx6A: undetectable	2vcvA-2yx6A: 20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DCJ_B_THHB401_0 (PROBABLE 5'-PHOSPHORIBOSYLGLY CINAMIDE FORMYLTRANSFERASE PURN)	2yx6	HYPOTHETICAL PROTEIN PH0822 (Pyrococcus horikoshii)	4 / 8	SER A 24 ILE A 59 LEU A 55 VAL A 45	None	0.76A	3dcjB-2yx6A: undetectable	3dcjB-2yx6A: 17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	2yx6	HYPOTHETICAL PROTEIN PH0822 (Pyrococcus horikoshii)	5 / 9	LEU A 107 LYS A 108 VAL A 17 GLY A 93 LEU A 68	None	1.03A	4b3oA-2yx6A: 3.1	4b3oA-2yx6A: 12.14

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2NNI_A_MTKA501_1","CYTOCHROME P450 2C8","2yx6","HYPOTHETICAL PROTEIN PH0822","Pyrococcus horikoshii",5,"SER A  24;SER A  18;VAL A  98;VAL A  28;VAL A   3","None","1.27A","2nniA-2yx6A:undetectable","2nniA-2yx6A:12.97"],["2VCV_A_ASDA1224_1","GLUTATHIONE S-TRANSFERASE A3","2yx6","HYPOTHETICAL PROTEIN PH0822","Pyrococcus horikoshii",4,"PRO A  56;ALA A  76;LEU A  55;PHE A  27","None","1.15A","2vcvA-2yx6A:undetectable","2vcvA-2yx6A:20.27"],["3DCJ_B_THHB401_0","PROBABLE 5'-PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE PURN","2yx6","HYPOTHETICAL PROTEIN PH0822","Pyrococcus horikoshii",4,"SER A  24;ILE A  59;LEU A  55;VAL A  45","None","0.76A","3dcjB-2yx6A:undetectable","3dcjB-2yx6A:17.67"],["4B3O_A_EFZA1557_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","2yx6","HYPOTHETICAL PROTEIN PH0822","Pyrococcus horikoshii",5,"LEU A 107;LYS A 108;VAL A  17;GLY A  93;LEU A  68","None","1.03A","4b3oA-2yx6A:3.1","4b3oA-2yx6A:12.14"]]