SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yxb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 2yxb COENZYME
B12-DEPENDENT MUTASE
(Aeropyrum
pernix) 		5 / 8 ARG A  90
LEU A  87
GLY A  76
ILE A  75
ILE A  79
 None
 1.35A 1d4yB-2yxbA:
undetectable		 1d4yB-2yxbA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yxb COENZYME
B12-DEPENDENT MUTASE
(Aeropyrum
pernix) 		4 / 8 LEU A 107
ILE A 127
GLU A 117
HIS A  84
 None
 0.89A 2azxA-2yxbA:
undetectable		 2azxA-2yxbA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2yxb COENZYME
B12-DEPENDENT MUTASE
(Aeropyrum
pernix) 		4 / 6 ILE A  75
ILE A 111
LEU A  95
MET A  88
 None
 0.85A 3adsA-2yxbA:
undetectable		 3adsA-2yxbA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2yxb COENZYME
B12-DEPENDENT MUTASE
(Aeropyrum
pernix) 		4 / 7 ILE A  75
ILE A 111
LEU A  95
MET A  88
 None
 0.83A 3adxA-2yxbA:
undetectable		 3adxA-2yxbA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_2
(PHOSPHOLIPASE A2)		 2yxb COENZYME
B12-DEPENDENT MUTASE
(Aeropyrum
pernix) 		5 / 9 VAL A  40
VAL A  39
GLY A  36
GLY A  76
ARG A  42
 None
 1.28A 3bjwG-2yxbA:
undetectable		 3bjwG-2yxbA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2yxb COENZYME
B12-DEPENDENT MUTASE
(Aeropyrum
pernix) 		5 / 10 ALA A  43
LEU A  44
PHE A  49
VAL A  23
ALA A 145
 None
 0.85A 4j14A-2yxbA:
undetectable		 4j14A-2yxbA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 2yxb COENZYME
B12-DEPENDENT MUTASE
(Aeropyrum
pernix) 		4 / 5 GLY A 109
THR A 110
HIS A  84
GLY A  82
 None
 1.20A 4v20A-2yxbA:
undetectable		 4v20A-2yxbA:
17.62