SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yxd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]
(Methanocaldococc
us
jannaschii) 		5 / 9 ASN A 136
GLU A 143
ARG A 147
ALA A 104
ILE A 106
 None
 1.33A 1aj6A-2yxdA:
undetectable		 1aj6A-2yxdA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]
(Methanocaldococc
us
jannaschii) 		4 / 8 GLY A  45
GLY A  47
GLY A  48
MET A  49
 SO4  A1001 ( 3.8A)
SO4  A1001 (-3.4A)
SO4  A1001 (-3.0A)
None
 0.49A 1qzzA-2yxdA:
14.1		 1qzzA-2yxdA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A  92
ILE A  63
ALA A 129
LEU A  31
MET A  49
 None
 1.33A 1udtA-2yxdA:
undetectable		 1udtA-2yxdA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAO_A_ACTA601_0
(VANILLYL-ALCOHOL
OXIDASE)		 2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]
(Methanocaldococc
us
jannaschii) 		4 / 5 TYR A 149
PHE A 144
ILE A 116
ARG A 183
 None
 1.50A 1vaoA-2yxdA:
0.0		 1vaoA-2yxdA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAO_B_ACTB601_0
(VANILLYL-ALCOHOL
OXIDASE)		 2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]
(Methanocaldococc
us
jannaschii) 		4 / 5 TYR A 149
PHE A 144
ILE A 116
ARG A 183
 None
 1.50A 1vaoB-2yxdA:
1.1		 1vaoB-2yxdA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A  19
GLY A  43
GLY A  45
GLY A  48
MET A  49
 SO4  A1001 (-3.8A)
None
SO4  A1001 ( 3.8A)
SO4  A1001 (-3.0A)
None
 0.92A 2b25A-2yxdA:
19.5		 2b25A-2yxdA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A  19
GLY A  45
SER A  46
GLY A  48
MET A  49
 SO4  A1001 (-3.8A)
SO4  A1001 ( 3.8A)
SO4  A1001 (-4.5A)
SO4  A1001 (-3.0A)
None
 0.68A 2b25B-2yxdA:
17.8		 2b25B-2yxdA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]
(Methanocaldococc
us
jannaschii) 		6 / 12 ILE A 132
ALA A 129
GLY A 107
VAL A  42
ASN A 136
PHE A 144
 None
 1.26A 2okcA-2yxdA:
11.9		 2okcA-2yxdA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]
(Methanocaldococc
us
jannaschii) 		6 / 12 ILE A 132
ALA A 129
GLY A 107
VAL A  42
ASN A 136
PHE A 144
 None
 1.24A 2okcB-2yxdA:
12.0		 2okcB-2yxdA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A  87
ALA A  62
LEU A  99
ILE A 127
ILE A 112
 None
 1.11A 3prsA-2yxdA:
undetectable		 3prsA-2yxdA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A 131
ALA A 129
ILE A 127
ALA A 181
ILE A 106
 None
 0.78A 4o2bD-2yxdA:
3.2		 4o2bD-2yxdA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  68
GLY A  90
VAL A  95
ASP A  64
ILE A  63
 None
 1.02A 5ehiA-2yxdA:
9.6		 5ehiA-2yxdA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  68
GLY A  90
VAL A  95
ASP A  64
ILE A  63
 None
 1.07A 5ehiC-2yxdA:
9.7		 5ehiC-2yxdA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  68
GLY A  90
VAL A  95
ASP A  64
ILE A  63
 None
 1.01A 5eiwA-2yxdA:
9.6		 5eiwA-2yxdA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  68
GLY A  90
VAL A  95
ASP A  64
ILE A  63
 None
 1.00A 5ekxA-2yxdA:
8.5		 5ekxA-2yxdA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A 131
ALA A 129
ILE A 127
ALA A 181
ILE A 106
 None
 0.78A 5eypB-2yxdA:
3.1		 5eypB-2yxdA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 127
LEU A 119
ASP A  41
VAL A  42
SER A  27
 None
 0.98A 5km9B-2yxdA:
undetectable		 5km9B-2yxdA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 112
ILE A 115
ASP A 120
ILE A 127
ALA A 104
 None
 1.05A 5lg3A-2yxdA:
undetectable		 5lg3A-2yxdA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 112
ILE A 115
ASP A 120
ILE A 127
ALA A 104
 None
 1.04A 5lg3E-2yxdA:
undetectable		 5lg3E-2yxdA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  68
GLY A  90
VAL A  95
ASP A  64
ILE A  63
 None
 1.03A 5wz1A-2yxdA:
9.6		 5wz1A-2yxdA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  68
GLY A  90
VAL A  95
ASP A  64
ILE A  63
 None
 1.01A 5wz1C-2yxdA:
9.6		 5wz1C-2yxdA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  68
GLY A  90
VAL A  95
ASP A  64
ILE A  63
 None
 1.01A 5wz1D-2yxdA:
9.7		 5wz1D-2yxdA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  68
GLY A  90
VAL A  95
ASP A  64
ILE A  63
 None
 1.03A 5wz1E-2yxdA:
9.7		 5wz1E-2yxdA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  68
GLY A  90
VAL A  95
ASP A  64
ILE A  63
 None
 1.00A 5wz1F-2yxdA:
9.7		 5wz1F-2yxdA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  68
GLY A  90
VAL A  95
ASP A  64
ILE A  63
 None
 1.05A 5wz1G-2yxdA:
9.7		 5wz1G-2yxdA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  68
GLY A  90
VAL A  95
ASP A  64
ILE A  63
 None
 1.01A 5wz1H-2yxdA:
9.6		 5wz1H-2yxdA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A 131
ALA A 129
ILE A 127
ALA A 181
ILE A 106
 None
 0.75A 5xiwB-2yxdA:
undetectable		 5xiwB-2yxdA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A 131
ALA A 129
ILE A 127
ALA A 181
ILE A 106
 None
 0.77A 5xiwD-2yxdA:
3.3		 5xiwD-2yxdA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]
(Methanocaldococc
us
jannaschii) 		4 / 6 VAL A 133
ASN A 136
ILE A 112
GLU A 113
 None
 1.21A 6h7uA-2yxdA:
undetectable		 6h7uA-2yxdA:
17.55