SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yxe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		4 / 8 GLU A 109
ASP A 136
THR A 138
LEU A 207
 None
 0.92A 1hmyA-2yxeA:
5.1		 1hmyA-2yxeA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 LEU A  38
PRO A  39
LEU A  42
 None
 0.53A 1hrkA-2yxeA:
2.2		 1hrkA-2yxeA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 140
ASP A 136
GLY A  85
ILE A 131
ILE A 133
 None
 0.84A 1hshA-2yxeA:
undetectable		 1hshA-2yxeA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 140
ASP A 136
GLY A  85
ILE A 131
ILE A 133
 None
 0.90A 1hshC-2yxeA:
undetectable		 1hshC-2yxeA:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		7 / 12 GLN A  58
ILE A 111
LEU A 114
ASP A 136
GLY A 137
ALA A 154
LEU A 207
 None
 0.77A 1jg2A-2yxeA:
35.1		 1jg2A-2yxeA:
50.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		11 / 12 GLY A  85
GLY A  87
GLU A 109
ILE A 111
LEU A 114
ASP A 136
GLY A 137
THR A 153
ALA A 154
VAL A 205
LEU A 207
 None
 0.47A 1jg2A-2yxeA:
35.1		 1jg2A-2yxeA:
50.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		9 / 11 GLN A  58
GLY A  85
GLU A 109
ILE A 111
LEU A 114
ASP A 136
GLY A 137
THR A 153
LEU A 207
 None
 0.72A 1jg3A-2yxeA:
35.0		 1jg3A-2yxeA:
50.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		10 / 11 GLY A  85
GLY A  87
GLU A 109
ARG A 110
ILE A 111
LEU A 114
ASP A 136
GLY A 137
THR A 153
LEU A 207
 None
 0.46A 1jg3A-2yxeA:
35.0		 1jg3A-2yxeA:
50.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		9 / 11 GLN A  58
GLY A  85
GLU A 109
ILE A 111
LEU A 114
ASP A 136
GLY A 137
THR A 153
LEU A 207
 None
 0.70A 1jg3B-2yxeA:
35.0		 1jg3B-2yxeA:
50.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		10 / 11 GLY A  85
GLY A  87
GLU A 109
ARG A 110
ILE A 111
LEU A 114
ASP A 136
GLY A 137
THR A 153
LEU A 207
 None
 0.45A 1jg3B-2yxeA:
35.0		 1jg3B-2yxeA:
50.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		7 / 12 GLN A  58
THR A  59
SER A  61
GLY A 137
ALA A 154
VAL A 205
LEU A 207
 None
 1.01A 1jg4A-2yxeA:
35.3		 1jg4A-2yxeA:
50.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		8 / 12 THR A  59
SER A  61
GLY A  87
GLY A 137
THR A 153
ALA A 154
VAL A 205
LEU A 207
 None
 0.66A 1jg4A-2yxeA:
35.3		 1jg4A-2yxeA:
50.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		7 / 8 GLU A  83
GLY A  85
GLU A 109
ARG A 110
ILE A 111
LEU A 114
ASP A 136
 None
 0.41A 1jg4A-2yxeA:
35.3		 1jg4A-2yxeA:
50.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLU A  83
GLY A  85
GLY A  87
LEU A 114
ASP A 136
 None
 0.72A 1qaoA-2yxeA:
9.3		 1qaoA-2yxeA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		4 / 6 PRO A 206
GLY A 156
PRO A 157
GLY A 178
 None
 0.72A 1usqB-2yxeA:
undetectable		 1usqB-2yxeA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		4 / 6 PRO A 206
GLY A 156
PRO A 157
GLY A 178
 None
 0.76A 1usqC-2yxeA:
undetectable		 1usqC-2yxeA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		4 / 6 PRO A 206
GLY A 156
PRO A 157
GLY A 178
 None
 0.74A 1usqD-2yxeA:
undetectable		 1usqD-2yxeA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		4 / 6 PRO A 206
GLY A 156
PRO A 157
GLY A 178
 None
 0.74A 1usqE-2yxeA:
undetectable		 1usqE-2yxeA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		4 / 7 PRO A 206
GLY A 156
PRO A 157
GLY A 178
 None
 0.74A 1usqF-2yxeA:
undetectable		 1usqF-2yxeA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A  75
ALA A  28
HIS A  91
TYR A 151
 None
 1.30A 2dpzA-2yxeA:
undetectable		 2dpzA-2yxeA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		4 / 6 PRO A 206
GLY A 156
PRO A 157
GLY A 178
 None
 0.71A 2jkjA-2yxeA:
undetectable		 2jkjA-2yxeA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		4 / 6 PRO A 206
GLY A 156
PRO A 157
GLY A 178
 None
 0.70A 2jkjB-2yxeA:
undetectable		 2jkjB-2yxeA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		4 / 6 PRO A 206
GLY A 156
PRO A 157
GLY A 178
 None
 0.71A 2jkjC-2yxeA:
undetectable		 2jkjC-2yxeA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		4 / 7 PRO A 206
GLY A 156
PRO A 157
GLY A 178
 None
 0.71A 2jkjE-2yxeA:
undetectable		 2jkjE-2yxeA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		4 / 6 PRO A 206
GLY A 156
PRO A 157
GLY A 178
 None
 0.74A 2jklB-2yxeA:
undetectable		 2jklB-2yxeA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		4 / 7 PRO A 206
GLY A 156
PRO A 157
GLY A 178
 None
 0.74A 2jklE-2yxeA:
undetectable		 2jklE-2yxeA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A  32
SER A 107
THR A 153
ARG A  34
ILE A  54
 None
 1.14A 2qm9B-2yxeA:
undetectable		 2qm9B-2yxeA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE A  11
LEU A  30
TYR A  90
THR A  95
 None
 0.95A 3ag2N-2yxeA:
2.5
3ag2W-2yxeA:
undetectable		 3ag2N-2yxeA:
17.67
3ag2W-2yxeA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 8 VAL A  81
THR A  95
PHE A  37
GLY A  89
ALA A  92
 None
 1.30A 3aruA-2yxeA:
undetectable		 3aruA-2yxeA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		6 / 11 GLU A  83
GLY A  85
GLY A  87
ILE A 108
GLU A 109
ASP A 136
 None
 0.62A 3dxyA-2yxeA:
10.0		 3dxyA-2yxeA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 11 GLY A  85
GLY A  87
GLU A 109
LEU A 114
ASP A 136
 None
 0.75A 3grvA-2yxeA:
11.6		 3grvA-2yxeA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		6 / 12 GLU A  83
GLY A  85
GLY A  87
GLU A 109
LEU A 114
ASP A 136
 None
 0.79A 3gryA-2yxeA:
11.5		 3gryA-2yxeA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		3 / 3 MET A  65
CYH A 199
PRO A 176
 None
 1.18A 3h52C-2yxeA:
undetectable		 3h52C-2yxeA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 131
SER A 107
GLU A  83
ARG A 123
THR A  86
 None
 1.17A 3r75A-2yxeA:
undetectable		 3r75A-2yxeA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 131
SER A 107
GLU A  83
ARG A 123
THR A  86
 None
 1.17A 3r75B-2yxeA:
undetectable		 3r75B-2yxeA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 131
SER A 107
GLU A  83
ARG A 123
THR A  86
 None
 1.16A 3r76A-2yxeA:
undetectable		 3r76A-2yxeA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 131
SER A 107
GLU A  83
ARG A 123
THR A  86
 None
 1.21A 3r76B-2yxeA:
undetectable		 3r76B-2yxeA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 140
ASP A 136
GLY A  85
ILE A 131
ILE A 133
 None
 0.82A 3s54B-2yxeA:
undetectable		 3s54B-2yxeA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ASP A 136
GLU A 211
GLY A 212
LEU A 139
 None
 0.97A 3w9tB-2yxeA:
undetectable		 3w9tB-2yxeA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ASP A 136
GLU A 211
GLY A 212
LEU A 139
 None
 0.97A 3w9tE-2yxeA:
undetectable		 3w9tE-2yxeA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ASP A 136
GLU A 211
GLY A 212
LEU A 139
 None
 0.96A 3w9tF-2yxeA:
undetectable		 3w9tF-2yxeA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		4 / 5 VAL A  99
ILE A 133
TYR A 127
ILE A 108
 None
 0.93A 4c8bA-2yxeA:
undetectable		 4c8bA-2yxeA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  87
CYH A  88
LEU A  38
LEU A 122
TYR A 127
 None
 1.47A 4emaA-2yxeA:
undetectable		 4emaA-2yxeA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 140
ASP A 136
GLY A  85
ILE A 131
ILE A 133
 None
 0.80A 5e5jA-2yxeA:
undetectable		 5e5jA-2yxeA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 140
ASP A 136
GLY A  85
ILE A 131
ILE A 133
 None
 0.82A 5e5kB-2yxeA:
undetectable		 5e5kB-2yxeA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		4 / 5 THR A  95
ALA A  92
TYR A 127
HIS A  91
 None
 1.40A 5ecmA-2yxeA:
undetectable		 5ecmA-2yxeA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		4 / 7 GLY A  85
GLY A  87
GLU A 109
ASP A 136
 None
 0.64A 5ergB-2yxeA:
11.9		 5ergB-2yxeA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 187
LEU A 186
ARG A 149
ILE A 150
LEU A 207
 None
ACT  A1001 (-4.6A)
None
None
None
 1.20A 5ljcA-2yxeA:
undetectable		 5ljcA-2yxeA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 130
ASP A 128
ALA A  93
PHE A  37
ARG A 120
 None
 1.38A 5nd2B-2yxeA:
undetectable		 5nd2B-2yxeA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 PRO A  51
ALA A  62
HIS A  64
GLU A 109
THR A 153
 None
 1.31A 5x6yC-2yxeA:
undetectable		 5x6yC-2yxeA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 140
ASP A 136
GLY A  85
ILE A 131
ILE A 133
 None
 0.88A 6dh3A-2yxeA:
undetectable		 6dh3A-2yxeA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLU A  83
ILE A  84
GLY A  85
GLY A  87
LEU A 114
 None
 0.49A 6iftA-2yxeA:
10.1		 6iftA-2yxeA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ILE A  11
LEU A  30
TYR A  90
THR A  95
 None
 1.02A 6nmfN-2yxeA:
2.4
6nmfW-2yxeA:
undetectable		 6nmfN-2yxeA:
17.67
6nmfW-2yxeA:
14.76