SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yxg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 2yxg DIHYDRODIPICOLINATE
SYNTHASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ALA A  98
VAL A 130
GLY A  37
ILE A  38
 None
 0.85A 1t7jB-2yxgA:
undetectable		 1t7jB-2yxgA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 2yxg DIHYDRODIPICOLINATE
SYNTHASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ALA A 253
LEU A 279
ALA A 240
SER A 202
VAL A 204
 None
 1.14A 2bxeA-2yxgA:
undetectable		 2bxeA-2yxgA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 2yxg DIHYDRODIPICOLINATE
SYNTHASE
(Methanocaldococc
us
jannaschii) 		3 / 3 HIS A 231
MET A 215
MET A 238
 None
 1.18A 2vj1A-2yxgA:
undetectable		 2vj1A-2yxgA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2yxg DIHYDRODIPICOLINATE
SYNTHASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 142
HIS A 117
SER A 124
GLY A  75
LEU A 100
 None
 1.19A 3j6pB-2yxgA:
1.9		 3j6pB-2yxgA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2yxg DIHYDRODIPICOLINATE
SYNTHASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 192
GLY A 197
ILE A 179
ASN A 133
ASN A 141
 None
 1.04A 4a81A-2yxgA:
undetectable		 4a81A-2yxgA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2yxg DIHYDRODIPICOLINATE
SYNTHASE
(Methanocaldococc
us
jannaschii) 		4 / 5 GLY A  42
LEU A  23
ILE A  59
LEU A 264
 None
 0.88A 4o8fA-2yxgA:
undetectable		 4o8fA-2yxgA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2yxg DIHYDRODIPICOLINATE
SYNTHASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ALA A  84
ARG A 115
GLY A 113
GLU A 112
 None
 0.91A 5bs8A-2yxgA:
undetectable
5bs8C-2yxgA:
undetectable
5bs8D-2yxgA:
undetectable		 5bs8A-2yxgA:
22.17
5bs8C-2yxgA:
22.17
5bs8D-2yxgA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2yxg DIHYDRODIPICOLINATE
SYNTHASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ALA A  84
ARG A 115
GLY A 113
GLU A 112
 None
 0.83A 5btgA-2yxgA:
undetectable
5btgB-2yxgA:
undetectable
5btgC-2yxgA:
undetectable		 5btgA-2yxgA:
22.17
5btgB-2yxgA:
22.68
5btgC-2yxgA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2yxg DIHYDRODIPICOLINATE
SYNTHASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ALA A  84
ARG A 115
GLY A 113
GLU A 112
 None
 0.81A 5btgA-2yxgA:
undetectable
5btgC-2yxgA:
undetectable
5btgD-2yxgA:
undetectable		 5btgA-2yxgA:
22.17
5btgC-2yxgA:
22.17
5btgD-2yxgA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 2yxg DIHYDRODIPICOLINATE
SYNTHASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  50
LEU A 254
MET A 257
ALA A   8
LEU A  30
 None
 1.37A 5ienA-2yxgA:
undetectable		 5ienA-2yxgA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 2yxg DIHYDRODIPICOLINATE
SYNTHASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A   8
LEU A  30
ILE A  31
ARG A  69
VAL A  62
 None
 1.18A 5vlmG-2yxgA:
undetectable		 5vlmG-2yxgA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2yxg DIHYDRODIPICOLINATE
SYNTHASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  87
GLY A  42
LEU A  23
ILE A  59
LEU A 264
 None
 1.20A 5y2tA-2yxgA:
undetectable		 5y2tA-2yxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 2yxg DIHYDRODIPICOLINATE
SYNTHASE
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A 190
PHE A 224
GLY A 196
GLY A   4
VAL A 200
 None
 1.12A 6eu9B-2yxgA:
undetectable		 6eu9B-2yxgA:
17.91