SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yxl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 PRO A 270
GLY A 271
GLY A 272
ARG A 320
LEU A 371
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-4.5A)
None
 0.55A 1eizA-2yxlA:
12.0		 1eizA-2yxlA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 ASP A 291
ASP A 318
ASP A 337
 SFG  A5748 (-2.9A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.6A)
 0.58A 1eizA-2yxlA:
12.0		 1eizA-2yxlA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 PRO A 270
GLY A 271
GLY A 272
ARG A 320
LEU A 371
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-4.5A)
None
 0.51A 1ej0A-2yxlA:
12.1		 1ej0A-2yxlA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 ASP A 291
ASP A 318
ASP A 337
 SFG  A5748 (-2.9A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.6A)
 0.63A 1ej0A-2yxlA:
12.1		 1ej0A-2yxlA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 GLY A  14
LEU A  53
VAL A  92
LEU A 110
ALA A 114
 None
 1.07A 1gseB-2yxlA:
undetectable		 1gseB-2yxlA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 GLU A 246
THR A 438
TYR A 420
TYR A 443
GLY A 440
 None
 1.20A 1httB-2yxlA:
undetectable		 1httB-2yxlA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 GLU A 246
THR A 438
TYR A 420
TYR A 443
GLY A 440
 None
 1.27A 1httC-2yxlA:
undetectable		 1httC-2yxlA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 GLU A 246
THR A 438
TYR A 420
TYR A 443
GLY A 440
 None
 1.22A 1httD-2yxlA:
undetectable		 1httD-2yxlA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		8 / 12 ALA A 269
GLY A 271
GLY A 272
LYS A 273
ASP A 293
ASP A 318
ARG A 320
PRO A 339
 SFG  A5748 (-4.3A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
None
SFG  A5748 (-3.7A)
SFG  A5748 (-4.5A)
SFG  A5748 (-4.0A)
 0.72A 1sqfA-2yxlA:
40.8		 1sqfA-2yxlA:
29.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 PRO A 270
ASP A 291
ASP A 337
 SFG  A5748 (-3.6A)
SFG  A5748 (-2.9A)
SFG  A5748 (-3.6A)
 0.48A 1sqfA-2yxlA:
40.8		 1sqfA-2yxlA:
29.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 LEU A  49
VAL A  52
VAL A  92
ILE A  96
 None
 0.89A 1t87B-2yxlA:
undetectable		 1t87B-2yxlA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 ALA A  97
TYR A 140
ILE A 137
ILE A  71
 None
 0.92A 1upfB-2yxlA:
undetectable		 1upfB-2yxlA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 SER A 374
VAL A 264
LEU A 266
 None
 0.70A 1yajG-2yxlA:
undetectable		 1yajG-2yxlA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		6 / 12 PRO A 270
GLY A 271
LYS A 273
ASP A 293
ARG A 296
ASP A 318
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
None
SFG  A5748 (-3.0A)
SFG  A5748 (-3.7A)
 0.70A 2b9eA-2yxlA:
31.1		 2b9eA-2yxlA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG9_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 GLU A 206
VAL A 212
ILE A 224
LEU A 222
TYR A 228
 None
 1.14A 2dg9A-2yxlA:
undetectable		 2dg9A-2yxlA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ALA A 267
VAL A 292
ASP A 293
ASP A 337
PRO A 339
 SFG  A5748 (-3.4A)
SFG  A5748 ( 3.9A)
None
SFG  A5748 (-3.6A)
SFG  A5748 (-4.0A)
 0.86A 2f8lA-2yxlA:
12.7		 2f8lA-2yxlA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 LEU A 335
LEU A 336
SER A 365
TYR A 443
 None
 1.05A 2hc4A-2yxlA:
2.3		 2hc4A-2yxlA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		4 / 4 PRO A 270
ASP A 291
ASP A 318
ASP A 265
 SFG  A5748 (-3.6A)
SFG  A5748 (-2.9A)
SFG  A5748 (-3.7A)
SFG  A5748 ( 4.4A)
 0.96A 2nyuA-2yxlA:
11.7		 2nyuA-2yxlA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		4 / 4 PRO A 270
ASP A 291
ASP A 318
ASP A 337
 SFG  A5748 (-3.6A)
SFG  A5748 (-2.9A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.6A)
 0.50A 2nyuA-2yxlA:
11.7		 2nyuA-2yxlA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 PRO A 270
ASP A 291
ASP A 318
ASP A 265
 SFG  A5748 (-3.6A)
SFG  A5748 (-2.9A)
SFG  A5748 (-3.7A)
SFG  A5748 ( 4.4A)
 1.02A 2nyuB-2yxlA:
11.9		 2nyuB-2yxlA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 PRO A 270
ASP A 291
ASP A 318
ASP A 337
 SFG  A5748 (-3.6A)
SFG  A5748 (-2.9A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.6A)
 0.46A 2nyuB-2yxlA:
11.9		 2nyuB-2yxlA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ALA A 319
THR A 274
ALA A 268
ASP A 291
ARG A 296
 SFG  A5748 (-3.4A)
None
None
SFG  A5748 (-2.9A)
SFG  A5748 (-3.0A)
 1.40A 2qm9A-2yxlA:
undetectable		 2qm9A-2yxlA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 ALA A 267
ASP A 291
ASP A 318
ARG A 320
 SFG  A5748 (-3.4A)
SFG  A5748 (-2.9A)
SFG  A5748 (-3.7A)
SFG  A5748 (-4.5A)
 0.66A 2uyqA-2yxlA:
9.4		 2uyqA-2yxlA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 ARG A 111
PHE A 138
LEU A 134
PHE A 130
 None
 1.19A 3abmC-2yxlA:
undetectable
3abmJ-2yxlA:
undetectable		 3abmC-2yxlA:
20.18
3abmJ-2yxlA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 ASP A 291
ASP A 318
ASP A 337
 SFG  A5748 (-2.9A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.6A)
 0.49A 3douA-2yxlA:
10.4		 3douA-2yxlA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 GLY A 272
ASP A 293
ASP A 318
PRO A 339
LEU A 371
 SFG  A5748 (-3.7A)
None
SFG  A5748 (-3.7A)
SFG  A5748 (-4.0A)
None
 0.93A 3eeoA-2yxlA:
9.0		 3eeoA-2yxlA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 LEU A 371
SER A 374
LEU A 378
LEU A 336
 None
 0.79A 3f33A-2yxlA:
undetectable		 3f33A-2yxlA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 PRO A 314
GLY A 272
GLY A 308
MET A 307
ILE A 242
 None
SFG  A5748 (-3.7A)
None
None
None
 0.93A 3ku1C-2yxlA:
10.9		 3ku1C-2yxlA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		8 / 12 ALA A 267
GLY A 271
GLY A 272
LYS A 273
VAL A 292
ASP A 293
ARG A 296
ASP A 337
 SFG  A5748 (-3.4A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 ( 3.9A)
None
SFG  A5748 (-3.0A)
SFG  A5748 (-3.6A)
 0.90A 3m6vA-2yxlA:
37.6		 3m6vA-2yxlA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		6 / 12 ALA A 267
GLY A 272
LYS A 273
ASP A 293
ARG A 296
ASP A 337
 SFG  A5748 (-3.4A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
None
SFG  A5748 (-3.0A)
SFG  A5748 (-3.6A)
 1.10A 3m6vA-2yxlA:
37.6		 3m6vA-2yxlA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		7 / 12 ALA A 267
GLY A 272
LYS A 273
ASP A 293
ASP A 337
PRO A 339
LEU A 371
 SFG  A5748 (-3.4A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
None
SFG  A5748 (-3.6A)
SFG  A5748 (-4.0A)
None
 0.92A 3m6vA-2yxlA:
37.6		 3m6vA-2yxlA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		10 / 12 ALA A 267
PRO A 270
GLY A 271
GLY A 272
LYS A 273
VAL A 292
ASP A 293
ASP A 337
PRO A 339
LEU A 371
 SFG  A5748 (-3.4A)
SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 ( 3.9A)
None
SFG  A5748 (-3.6A)
SFG  A5748 (-4.0A)
None
 0.78A 3m6vA-2yxlA:
37.6		 3m6vA-2yxlA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		6 / 12 PRO A 270
GLY A 271
VAL A 292
ASP A 293
PRO A 339
LEU A 367
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 ( 3.9A)
None
SFG  A5748 (-4.0A)
None
 1.50A 3m6vA-2yxlA:
37.6		 3m6vA-2yxlA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		8 / 12 ALA A 267
GLY A 271
GLY A 272
LYS A 273
VAL A 292
ASP A 293
ARG A 296
ASP A 337
 SFG  A5748 (-3.4A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 ( 3.9A)
None
SFG  A5748 (-3.0A)
SFG  A5748 (-3.6A)
 0.92A 3m6vB-2yxlA:
37.5		 3m6vB-2yxlA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		6 / 12 ALA A 267
GLY A 272
LYS A 273
ASP A 293
ARG A 296
ASP A 337
 SFG  A5748 (-3.4A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
None
SFG  A5748 (-3.0A)
SFG  A5748 (-3.6A)
 1.09A 3m6vB-2yxlA:
37.5		 3m6vB-2yxlA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		7 / 12 ALA A 267
GLY A 272
LYS A 273
ASP A 293
ASP A 337
PRO A 339
LEU A 371
 SFG  A5748 (-3.4A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
None
SFG  A5748 (-3.6A)
SFG  A5748 (-4.0A)
None
 0.92A 3m6vB-2yxlA:
37.5		 3m6vB-2yxlA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		10 / 12 ALA A 267
PRO A 270
GLY A 271
GLY A 272
LYS A 273
VAL A 292
ASP A 293
ASP A 337
PRO A 339
LEU A 371
 SFG  A5748 (-3.4A)
SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 ( 3.9A)
None
SFG  A5748 (-3.6A)
SFG  A5748 (-4.0A)
None
 0.84A 3m6vB-2yxlA:
37.5		 3m6vB-2yxlA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		6 / 12 PRO A 270
GLY A 271
VAL A 292
ASP A 293
PRO A 339
LEU A 367
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 ( 3.9A)
None
SFG  A5748 (-4.0A)
None
 1.47A 3m6vB-2yxlA:
37.5		 3m6vB-2yxlA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		6 / 12 ALA A 267
GLY A 272
LYS A 273
ASP A 293
PRO A 339
LEU A 371
 SFG  A5748 (-3.4A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
None
SFG  A5748 (-4.0A)
None
 0.92A 3m6wA-2yxlA:
37.6		 3m6wA-2yxlA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		9 / 12 ALA A 267
PRO A 270
GLY A 271
GLY A 272
LYS A 273
VAL A 292
ASP A 293
PRO A 339
LEU A 371
 SFG  A5748 (-3.4A)
SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 ( 3.9A)
None
SFG  A5748 (-4.0A)
None
 0.83A 3m6wA-2yxlA:
37.6		 3m6wA-2yxlA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		6 / 12 GLY A 271
GLY A 272
LYS A 273
VAL A 292
ASP A 293
ARG A 296
 SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 ( 3.9A)
None
SFG  A5748 (-3.0A)
 0.85A 3m6wA-2yxlA:
37.6		 3m6wA-2yxlA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 ARG A 353
LEU A 161
THR A 173
 None
 0.68A 3oxcA-2yxlA:
undetectable		 3oxcA-2yxlA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 PHE A 117
ILE A  19
GLY A  14
HIS A  42
 None
 1.39A 3r0lD-2yxlA:
undetectable		 3r0lD-2yxlA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 THR A 388
GLY A 440
PHE A 441
SER A 343
 None
 0.90A 3tzfB-2yxlA:
undetectable		 3tzfB-2yxlA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 ASP A 291
ASP A 293
ASP A 318
PRO A 339
LEU A 367
 SFG  A5748 (-2.9A)
None
SFG  A5748 (-3.7A)
SFG  A5748 (-4.0A)
None
 1.19A 3v8vB-2yxlA:
13.4		 3v8vB-2yxlA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 ASP A 291
ASP A 293
ASP A 318
PRO A 339
LEU A 371
 SFG  A5748 (-2.9A)
None
SFG  A5748 (-3.7A)
SFG  A5748 (-4.0A)
None
 1.10A 3v8vB-2yxlA:
13.4		 3v8vB-2yxlA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		6 / 12 PRO A 270
GLY A 271
GLY A 272
ASP A 291
ASP A 318
ASP A 337
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-2.9A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.6A)
 0.75A 4b17A-2yxlA:
10.5		 4b17A-2yxlA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DMG_A_SAMA401_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ASP A 291
ASP A 293
ALA A 319
ASP A 337
PRO A 339
 SFG  A5748 (-2.9A)
None
SFG  A5748 (-3.4A)
SFG  A5748 (-3.6A)
SFG  A5748 (-4.0A)
 0.65A 4dmgA-2yxlA:
14.4		 4dmgA-2yxlA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DMG_B_SAMB401_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 ASP A 291
ASP A 293
ALA A 319
ASP A 337
PRO A 339
 SFG  A5748 (-2.9A)
None
SFG  A5748 (-3.4A)
SFG  A5748 (-3.6A)
SFG  A5748 (-4.0A)
 0.76A 4dmgB-2yxlA:
14.5		 4dmgB-2yxlA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		7 / 12 PRO A 270
GLY A 271
GLY A 272
LYS A 273
ASP A 337
PRO A 339
LEU A 371
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 (-3.6A)
SFG  A5748 (-4.0A)
None
 0.32A 4fp9A-2yxlA:
28.2		 4fp9A-2yxlA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		7 / 12 PRO A 270
GLY A 271
GLY A 272
LYS A 273
ASP A 337
PRO A 339
LEU A 371
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 (-3.6A)
SFG  A5748 (-4.0A)
None
 0.30A 4fp9C-2yxlA:
28.2		 4fp9C-2yxlA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		7 / 12 PRO A 270
GLY A 271
GLY A 272
LYS A 273
ASP A 318
PRO A 339
LEU A 371
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 (-3.7A)
SFG  A5748 (-4.0A)
None
 0.40A 4fp9D-2yxlA:
28.3		 4fp9D-2yxlA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		7 / 12 PRO A 270
GLY A 271
GLY A 272
LYS A 273
ASP A 337
PRO A 339
LEU A 371
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 (-3.6A)
SFG  A5748 (-4.0A)
None
 0.32A 4fp9F-2yxlA:
28.1		 4fp9F-2yxlA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		7 / 12 PRO A 270
GLY A 271
GLY A 272
LYS A 273
ASP A 318
PRO A 339
LEU A 371
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 (-3.7A)
SFG  A5748 (-4.0A)
None
 0.36A 4fzvA-2yxlA:
28.1		 4fzvA-2yxlA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 VAL A  52
ARG A  51
MET A  55
GLU A 185
 None
 1.26A 4hojA-2yxlA:
undetectable		 4hojA-2yxlA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 ARG A 353
LYS A  63
LYS A  62
 None
 1.02A 4k50A-2yxlA:
2.0		 4k50A-2yxlA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 ARG A 353
LYS A  63
LYS A  62
 None
 1.07A 4k50E-2yxlA:
1.4		 4k50E-2yxlA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 ARG A 353
LYS A  63
LYS A  62
 None
 1.02A 4k50I-2yxlA:
undetectable		 4k50I-2yxlA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 PRO A 270
GLY A 272
ASP A 318
ASP A 337
 SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.6A)
 0.51A 4n48B-2yxlA:
10.6		 4n48B-2yxlA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 GLU A 246
THR A 438
TYR A 420
TYR A 443
GLY A 440
 None
 1.24A 5e3iA-2yxlA:
undetectable		 5e3iA-2yxlA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 GLU A 246
THR A 438
TYR A 420
TYR A 443
GLY A 440
 None
 1.25A 5e3iB-2yxlA:
undetectable		 5e3iB-2yxlA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ALA A 322
ASP A 291
PRO A 339
PHE A 290
SER A 374
 None
SFG  A5748 (-2.9A)
SFG  A5748 (-4.0A)
None
None
 1.08A 5hfjE-2yxlA:
2.9		 5hfjE-2yxlA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ALA A 269
PRO A 270
ASP A 291
ASP A 318
LEU A 367
 SFG  A5748 (-4.3A)
SFG  A5748 (-3.6A)
SFG  A5748 (-2.9A)
SFG  A5748 (-3.7A)
None
 0.93A 5wwsA-2yxlA:
32.2		 5wwsA-2yxlA:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		8 / 12 ALA A 269
PRO A 270
GLY A 272
ASP A 291
ASP A 318
ASP A 337
LEU A 367
LEU A 371
 SFG  A5748 (-4.3A)
SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-2.9A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.6A)
None
None
 0.31A 5wwsA-2yxlA:
32.2		 5wwsA-2yxlA:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		7 / 12 ALA A 269
PRO A 270
GLY A 272
LYS A 273
ASP A 291
ASP A 318
ASP A 337
 SFG  A5748 (-4.3A)
SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 (-2.9A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.6A)
 0.36A 5wwsB-2yxlA:
35.6		 5wwsB-2yxlA:
27.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		8 / 12 ALA A 267
PRO A 270
GLY A 272
LYS A 273
ASP A 318
ALA A 319
ARG A 320
PRO A 339
 SFG  A5748 (-3.4A)
SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.4A)
SFG  A5748 (-4.5A)
SFG  A5748 (-4.0A)
 0.32A 5zvgA-2yxlA:
38.4		 5zvgA-2yxlA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		8 / 12 ALA A 267
PRO A 270
GLY A 272
LYS A 273
ASP A 318
ALA A 319
ARG A 320
PRO A 339
 SFG  A5748 (-3.4A)
SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.4A)
SFG  A5748 (-4.5A)
SFG  A5748 (-4.0A)
 0.32A 5zvgB-2yxlA:
38.5		 5zvgB-2yxlA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 ASP A 291
ARG A 296
ASP A 337
 SFG  A5748 (-2.9A)
SFG  A5748 (-3.0A)
SFG  A5748 (-3.6A)
 0.89A 5zvgB-2yxlA:
38.5		 5zvgB-2yxlA:
32.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ASP A 291
ASP A 293
ASP A 318
ALA A 319
LEU A 371
 SFG  A5748 (-2.9A)
None
SFG  A5748 (-3.7A)
SFG  A5748 (-3.4A)
None
 0.83A 6bq4A-2yxlA:
11.3		 6bq4A-2yxlA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 SER A 115
LEU A 134
ALA A  93
ALA A  89
PHE A 130
 None
 1.45A 6qgbA-2yxlA:
undetectable		 6qgbA-2yxlA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 SER A 115
LEU A 134
ALA A  93
ALA A  89
PHE A 130
 None
 1.48A 6qgbE-2yxlA:
undetectable		 6qgbE-2yxlA:
19.31