SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yxx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 7 PHE A 296
LEU A 326
VAL A 265
VAL A 262
 None
 0.86A 1epbA-2yxxA:
undetectable		 1epbA-2yxxA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 12 SER A 255
VAL A 252
LEU A  57
GLY A 341
MET A  64
 None
 1.45A 1fdsA-2yxxA:
undetectable		 1fdsA-2yxxA:
22.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TUF_A_AZ1A502_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		6 / 9 HIS A 179
GLY A 181
SER A 182
ARG A 249
ARG A 285
TYR A 289
 PLP  A 401 (-3.6A)
None
PLP  A 401 (-2.6A)
None
None
None
 0.57A 1tufA-2yxxA:
47.1
1tufB-2yxxA:
47.5		 1tufA-2yxxA:
38.78
1tufB-2yxxA:
38.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TUF_B_AZ1B503_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 6 SER A 182
ARG A 249
ARG A 285
TYR A 289
TYR A 343
 PLP  A 401 (-2.6A)
None
None
None
PLP  A 401 (-4.6A)
 0.68A 1tufA-2yxxA:
47.1
1tufB-2yxxA:
47.5		 1tufA-2yxxA:
38.78
1tufB-2yxxA:
38.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 12 GLU A 359
TYR A  18
TYR A  16
ASN A  48
VAL A 252
 None
 1.45A 1x70A-2yxxA:
undetectable		 1x70A-2yxxA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 12 GLU A 359
TYR A  18
TYR A  16
ASN A  48
VAL A 252
 None
 1.44A 1x70B-2yxxA:
undetectable		 1x70B-2yxxA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 11 ARG A 174
ILE A 173
HIS A 177
GLY A 205
LEU A 161
 None
None
PLP  A 401 ( 4.8A)
None
None
 1.14A 2azyA-2yxxA:
undetectable		 2azyA-2yxxA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 8 ARG A 174
ILE A 173
ASP A 162
LEU A 161
PHE A 164
 None
 1.40A 2tsrB-2yxxA:
undetectable		 2tsrB-2yxxA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 9 ILE A 209
ILE A 211
PHE A  34
ILE A 107
VAL A 252
 None
 1.41A 2ygpA-2yxxA:
0.0		 2ygpA-2yxxA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 12 GLU A 359
TYR A  18
TYR A  16
ASN A  48
VAL A 252
 None
 1.44A 3bjmA-2yxxA:
2.6		 3bjmA-2yxxA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 12 GLU A 359
TYR A  18
TYR A  16
ASN A  48
VAL A 252
 None
 1.44A 3bjmB-2yxxA:
undetectable		 3bjmB-2yxxA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 12 GLU A 359
TYR A  18
TYR A  16
ASN A  48
VAL A 252
 None
 1.45A 3g0bA-2yxxA:
undetectable		 3g0bA-2yxxA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 12 GLU A 359
TYR A  18
TYR A  16
ASN A  48
VAL A 252
 None
 1.46A 3g0bB-2yxxA:
undetectable		 3g0bB-2yxxA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 12 GLU A 359
TYR A  18
TYR A  16
ASN A  48
VAL A 252
 None
 1.44A 3g0bC-2yxxA:
undetectable		 3g0bC-2yxxA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 12 GLU A 359
TYR A  18
TYR A  16
ASN A  48
VAL A 252
 None
 1.43A 3g0bD-2yxxA:
undetectable		 3g0bD-2yxxA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 12 GLY A 213
GLY A 212
VAL A 252
ASP A  65
LEU A  54
 PLP  A 401 ( 4.1A)
PLP  A 401 ( 4.6A)
None
PLP  A 401 (-4.1A)
None
 0.84A 3m6vA-2yxxA:
undetectable		 3m6vA-2yxxA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 12 GLY A 213
GLY A 212
VAL A 252
ASP A  65
LEU A  54
 PLP  A 401 ( 4.1A)
PLP  A 401 ( 4.6A)
None
PLP  A 401 (-4.1A)
None
 0.90A 3m6vB-2yxxA:
undetectable		 3m6vB-2yxxA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_B_AG2B1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 9 LYS A  46
HIS A 179
GLY A 181
SER A 182
TYR A 343
 PLP  A 401 (-2.0A)
PLP  A 401 (-3.6A)
None
PLP  A 401 (-2.6A)
PLP  A 401 (-4.6A)
 0.73A 3n2oA-2yxxA:
14.5
3n2oB-2yxxA:
14.2		 3n2oA-2yxxA:
22.63
3n2oB-2yxxA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_D_AG2D1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 10 LYS A  46
HIS A 179
GLY A 181
ARG A 249
TYR A 343
 PLP  A 401 (-2.0A)
PLP  A 401 (-3.6A)
None
None
PLP  A 401 (-4.6A)
 0.60A 3n2oC-2yxxA:
26.7
3n2oD-2yxxA:
13.2		 3n2oC-2yxxA:
22.63
3n2oD-2yxxA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		3 / 3 VAL A  66
VAL A  80
SER A  82
 None
 0.67A 3n8xB-2yxxA:
undetectable		 3n8xB-2yxxA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 5 VAL A  33
PHE A  62
ILE A 251
PHE A  43
 None
 1.12A 3owxB-2yxxA:
undetectable		 3owxB-2yxxA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 11 ALA A 321
VAL A 337
GLY A 311
VAL A 275
ILE A 295
 None
 1.05A 3oxvD-2yxxA:
undetectable		 3oxvD-2yxxA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		3 / 3 LEU A 260
ARG A 285
ASN A 349
 None
 0.75A 3qxvD-2yxxA:
undetectable		 3qxvD-2yxxA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 6 VAL A 110
MET A 116
PHE A 164
VAL A 133
 None
 1.02A 3soaA-2yxxA:
undetectable		 3soaA-2yxxA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 12 PHE A 190
LEU A  39
VAL A  37
ILE A 211
HIS A 179
 None
None
None
None
PLP  A 401 (-3.6A)
 1.27A 3sp9A-2yxxA:
undetectable		 3sp9A-2yxxA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 7 ASN A 134
ILE A 156
PHE A 164
MET A 165
 None
 1.17A 3tvxB-2yxxA:
undetectable		 3tvxB-2yxxA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 8 THR A 355
ARG A 356
PRO A 357
GLY A 278
 None
 0.97A 3tzfB-2yxxA:
9.2		 3tzfB-2yxxA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 12 GLU A 359
TYR A  18
TYR A  16
ASN A  48
VAL A 252
 None
 1.44A 3w2tA-2yxxA:
undetectable		 3w2tA-2yxxA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 12 GLU A 359
TYR A  18
TYR A  16
ASN A  48
VAL A 252
 None
 1.42A 3w2tB-2yxxA:
undetectable		 3w2tB-2yxxA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 6 GLY A 311
PRO A 312
LEU A 260
VAL A 276
 None
 0.64A 4dubA-2yxxA:
undetectable		 4dubA-2yxxA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 6 GLY A 311
PRO A 312
LEU A 260
VAL A 276
 None
 0.63A 4dubB-2yxxA:
undetectable		 4dubB-2yxxA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 9 ARG A 324
ASP A 277
LEU A 260
GLY A 278
ASN A 281
 None
 1.32A 4eb4C-2yxxA:
undetectable		 4eb4C-2yxxA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 7 ILE A 173
ASP A 162
LEU A 161
PHE A 164
 None
 0.89A 4iqqA-2yxxA:
undetectable		 4iqqA-2yxxA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 8 ILE A 173
ASP A 162
LEU A 161
PHE A 164
 None
 0.86A 4iqqD-2yxxA:
undetectable		 4iqqD-2yxxA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 11 GLY A 205
ALA A 200
GLY A 175
ILE A 184
LEU A 224
 None
 1.11A 4kt0A-2yxxA:
undetectable
4kt0J-2yxxA:
undetectable		 4kt0A-2yxxA:
18.75
4kt0J-2yxxA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 7 GLU A  59
GLU A  60
GLU A  20
GLU A 364
 None
 1.08A 4r87I-2yxxA:
undetectable		 4r87I-2yxxA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 5 ILE A 180
VAL A 178
PHE A 164
HIS A 142
 None
 1.32A 4rzvA-2yxxA:
undetectable		 4rzvA-2yxxA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		3 / 3 ASP A 104
VAL A  85
LEU A  72
 None
 0.67A 5e5jB-2yxxA:
undetectable		 5e5jB-2yxxA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 7 ILE A 173
ASP A 162
LEU A 161
PHE A 164
 None
 0.77A 5h3aB-2yxxA:
undetectable		 5h3aB-2yxxA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_B_Z80B401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 9 ILE A 180
PHE A 190
VAL A 197
ASN A 210
GLU A 246
 None
None
None
None
PLP  A 401 (-3.6A)
 1.31A 5lg3B-2yxxA:
undetectable		 5lg3B-2yxxA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_C_Z80C401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 9 ILE A 180
PHE A 190
VAL A 197
ASN A 210
GLU A 246
 None
None
None
None
PLP  A 401 (-3.6A)
 1.29A 5lg3C-2yxxA:
undetectable		 5lg3C-2yxxA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_D_Z80D401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 9 ILE A 180
PHE A 190
VAL A 197
ASN A 210
GLU A 246
 None
None
None
None
PLP  A 401 (-3.6A)
 1.28A 5lg3D-2yxxA:
undetectable		 5lg3D-2yxxA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 10 ILE A 180
PHE A 190
VAL A 197
ASN A 210
GLU A 246
 None
None
None
None
PLP  A 401 (-3.6A)
 1.29A 5lg3G-2yxxA:
undetectable		 5lg3G-2yxxA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 10 ILE A 180
PHE A 190
VAL A 197
ASN A 210
GLU A 246
 None
None
None
None
PLP  A 401 (-3.6A)
 1.27A 5lg3H-2yxxA:
undetectable		 5lg3H-2yxxA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 9 ILE A 180
PHE A 190
VAL A 197
ASN A 210
 None
 0.93A 5lg3I-2yxxA:
undetectable		 5lg3I-2yxxA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 8 ARG A 132
ILE A 173
ASP A 162
LEU A 161
PHE A 164
 PLP  A 401 ( 4.0A)
None
None
None
None
 0.98A 5nooD-2yxxA:
undetectable		 5nooD-2yxxA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 9 VAL A 329
GLY A 311
VAL A 310
ASP A 277
GLY A 278
 None
 1.17A 5zniA-2yxxA:
undetectable		 5zniA-2yxxA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 12 GLU A 359
TYR A  18
TYR A  16
ASN A  48
VAL A 252
 None
 1.45A 6b1eB-2yxxA:
undetectable		 6b1eB-2yxxA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 2yxx DIAMINOPIMELATE
DECARBOXYLASE
(Thermotoga
maritima) 		3 / 3 ASP A 225
LEU A 224
ARG A  26
 None
 0.87A 7dfrA-2yxxA:
undetectable		 7dfrA-2yxxA:
18.77