SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yxz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 2yxz THIAMIN-MONOPHOSPHAT
E KINASE
(Thermus
thermophilus) 		4 / 7 VAL A 252
LEU A 298
VAL A 229
LEU A 234
 None
 0.79A 1cqpA-2yxzA:
undetectable
1cqpB-2yxzA:
undetectable		 1cqpA-2yxzA:
19.35
1cqpB-2yxzA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 2yxz THIAMIN-MONOPHOSPHAT
E KINASE
(Thermus
thermophilus) 		5 / 12 ARG A 163
GLY A 162
LEU A 232
LEU A 239
ALA A 242
 None
 1.05A 1gseB-2yxzA:
undetectable		 1gseB-2yxzA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 2yxz THIAMIN-MONOPHOSPHAT
E KINASE
(Thermus
thermophilus) 		5 / 11 LEU A 284
LEU A 199
LEU A 203
SER A 206
ALA A 261
 None
 1.06A 1ha2A-2yxzA:
undetectable		 1ha2A-2yxzA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 2yxz THIAMIN-MONOPHOSPHAT
E KINASE
(Thermus
thermophilus) 		5 / 10 GLU A 173
GLU A 250
ALA A 247
LEU A 251
ALA A 242
 None
 1.25A 1mjqG-2yxzA:
undetectable
1mjqH-2yxzA:
undetectable		 1mjqG-2yxzA:
20.08
1mjqH-2yxzA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 2yxz THIAMIN-MONOPHOSPHAT
E KINASE
(Thermus
thermophilus) 		5 / 11 LEU A 298
ALA A 247
VAL A 229
TYR A 254
LEU A 213
 None
 1.00A 1rlbF-2yxzA:
undetectable		 1rlbF-2yxzA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2yxz THIAMIN-MONOPHOSPHAT
E KINASE
(Thermus
thermophilus) 		6 / 12 GLY A 162
ALA A 248
ALA A 240
LEU A 253
LEU A 249
LEU A 156
 None
 1.44A 2nyuA-2yxzA:
undetectable		 2nyuA-2yxzA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2yxz THIAMIN-MONOPHOSPHAT
E KINASE
(Thermus
thermophilus) 		5 / 6 PHE A  86
LEU A  77
ALA A 138
LEU A  84
ALA A 117
 None
 1.45A 2vcvB-2yxzA:
undetectable		 2vcvB-2yxzA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2yxz THIAMIN-MONOPHOSPHAT
E KINASE
(Thermus
thermophilus) 		5 / 6 PHE A  86
LEU A  77
ALA A 138
LEU A  84
ALA A 117
 None
 1.45A 2vcvK-2yxzA:
undetectable		 2vcvK-2yxzA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 2yxz THIAMIN-MONOPHOSPHAT
E KINASE
(Thermus
thermophilus) 		4 / 7 LEU A  90
ALA A 108
GLY A  68
PHE A  91
 None
 0.96A 2wq5A-2yxzA:
undetectable		 2wq5A-2yxzA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 2yxz THIAMIN-MONOPHOSPHAT
E KINASE
(Thermus
thermophilus) 		4 / 8 ARG A 160
SER A 210
ASP A  47
VAL A  69
 None
 1.15A 3jq7C-2yxzA:
undetectable		 3jq7C-2yxzA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 2yxz THIAMIN-MONOPHOSPHAT
E KINASE
(Thermus
thermophilus) 		5 / 12 VAL A 134
LEU A 132
VAL A 105
GLY A 107
ALA A 108
 None
 1.06A 3nt1A-2yxzA:
undetectable		 3nt1A-2yxzA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 2yxz THIAMIN-MONOPHOSPHAT
E KINASE
(Thermus
thermophilus) 		5 / 12 VAL A 134
LEU A 132
VAL A 105
GLY A 107
ALA A 108
 None
 1.07A 3nt1B-2yxzA:
undetectable		 3nt1B-2yxzA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 2yxz THIAMIN-MONOPHOSPHAT
E KINASE
(Thermus
thermophilus) 		4 / 7 LEU A 220
VAL A 227
VAL A 264
LEU A 298
 None
 0.96A 3rgfA-2yxzA:
undetectable		 3rgfA-2yxzA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2yxz THIAMIN-MONOPHOSPHAT
E KINASE
(Thermus
thermophilus) 		5 / 12 VAL A 134
LEU A 132
VAL A 105
GLY A 107
ALA A 108
 None
 1.10A 3rr3C-2yxzA:
undetectable		 3rr3C-2yxzA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2yxz THIAMIN-MONOPHOSPHAT
E KINASE
(Thermus
thermophilus) 		5 / 12 VAL A 134
LEU A 132
VAL A 105
GLY A 107
ALA A 108
 None
 1.10A 3rr3D-2yxzA:
undetectable		 3rr3D-2yxzA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 2yxz THIAMIN-MONOPHOSPHAT
E KINASE
(Thermus
thermophilus) 		4 / 5 GLU A 110
GLY A 107
TYR A 189
GLU A  63
 None
 1.20A 3w9tC-2yxzA:
undetectable		 3w9tC-2yxzA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 2yxz THIAMIN-MONOPHOSPHAT
E KINASE
(Thermus
thermophilus) 		3 / 3 ASP A  30
ARG A 146
ASP A  75
 None
 0.87A 4fp9D-2yxzA:
undetectable		 4fp9D-2yxzA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2yxz THIAMIN-MONOPHOSPHAT
E KINASE
(Thermus
thermophilus) 		5 / 12 VAL A 134
LEU A 132
VAL A 105
GLY A 107
ALA A 108
 None
 1.08A 4rrwC-2yxzA:
undetectable		 4rrwC-2yxzA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2yxz THIAMIN-MONOPHOSPHAT
E KINASE
(Thermus
thermophilus) 		5 / 12 VAL A 134
LEU A 132
VAL A 105
GLY A 107
ALA A 108
 None
 1.08A 4rrzC-2yxzA:
undetectable		 4rrzC-2yxzA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2yxz THIAMIN-MONOPHOSPHAT
E KINASE
(Thermus
thermophilus) 		3 / 4 ARG A 175
GLY A 174
GLU A 173
 None
 0.58A 4z2dB-2yxzA:
undetectable
4z2dC-2yxzA:
undetectable		 4z2dB-2yxzA:
20.75
4z2dC-2yxzA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2yxz THIAMIN-MONOPHOSPHAT
E KINASE
(Thermus
thermophilus) 		4 / 8 LEU A 156
THR A 216
LEU A 217
LEU A 213
 None
 0.72A 4z90F-2yxzA:
undetectable
4z90G-2yxzA:
undetectable
4z90H-2yxzA:
undetectable
4z90I-2yxzA:
undetectable
4z90J-2yxzA:
undetectable		 4z90F-2yxzA:
24.86
4z90G-2yxzA:
24.86
4z90H-2yxzA:
24.86
4z90I-2yxzA:
24.86
4z90J-2yxzA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 2yxz THIAMIN-MONOPHOSPHAT
E KINASE
(Thermus
thermophilus) 		5 / 10 PHE A  86
ALA A 112
LEU A 197
LEU A  76
LEU A  77
 None
 1.29A 4zmeB-2yxzA:
undetectable		 4zmeB-2yxzA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2yxz THIAMIN-MONOPHOSPHAT
E KINASE
(Thermus
thermophilus) 		5 / 12 VAL A 134
LEU A 132
VAL A 105
GLY A 107
ALA A 108
 None
 1.09A 5jvzA-2yxzA:
undetectable		 5jvzA-2yxzA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2yxz THIAMIN-MONOPHOSPHAT
E KINASE
(Thermus
thermophilus) 		4 / 8 THR A 164
GLY A 165
ALA A 167
GLY A 255
 None
 0.59A 5vw9A-2yxzA:
undetectable		 5vw9A-2yxzA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 2yxz THIAMIN-MONOPHOSPHAT
E KINASE
(Thermus
thermophilus) 		5 / 12 LEU A 253
LEU A 232
ALA A 287
LEU A 213
GLY A 226
 None
 0.97A 6b0cD-2yxzA:
undetectable		 6b0cD-2yxzA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 2yxz THIAMIN-MONOPHOSPHAT
E KINASE
(Thermus
thermophilus) 		3 / 3 TYR A 137
PRO A  83
LEU A  76
 None
 0.93A 6beoA-2yxzA:
undetectable		 6beoA-2yxzA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 2yxz THIAMIN-MONOPHOSPHAT
E KINASE
(Thermus
thermophilus) 		4 / 8 LEU A 298
LEU A 303
GLY A 162
TYR A 254
 None
 0.82A 6ce2A-2yxzA:
undetectable		 6ce2A-2yxzA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2yxz THIAMIN-MONOPHOSPHAT
E KINASE
(Thermus
thermophilus) 		5 / 9 VAL A 264
LEU A 154
LEU A 217
GLN A 219
VAL A 225
 None
 1.03A 6czmA-2yxzA:
2.7
6czmB-2yxzA:
2.4		 6czmA-2yxzA:
24.43
6czmB-2yxzA:
24.43