SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yy5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 12 HIS A  16
GLY A  18
GLY A 152
ASP A 154
GLN A 155
 SO4  A1362 ( 4.1A)
WSA  A1350 (-3.5A)
WSA  A1350 (-3.2A)
WSA  A1350 (-2.7A)
SO4  A1363 ( 3.2A)
 0.69A 1ffyA-2yy5A:
5.8		 1ffyA-2yy5A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 11 GLY A   8
HIS A  16
GLY A 152
ASP A 154
GLN A 155
 WSA  A1350 (-3.7A)
SO4  A1362 ( 4.1A)
WSA  A1350 (-3.2A)
WSA  A1350 (-2.7A)
SO4  A1363 ( 3.2A)
 0.81A 1jzsA-2yy5A:
undetectable		 1jzsA-2yy5A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 11 GLY A   8
HIS A  16
GLY A 152
GLN A 155
ILE A 191
 WSA  A1350 (-3.7A)
SO4  A1362 ( 4.1A)
WSA  A1350 (-3.2A)
SO4  A1363 ( 3.2A)
WSA  A1350 (-3.7A)
 0.89A 1jzsA-2yy5A:
undetectable		 1jzsA-2yy5A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 12 HIS A  16
GLY A  18
GLY A 152
ASP A 154
GLN A 155
 SO4  A1362 ( 4.1A)
WSA  A1350 (-3.5A)
WSA  A1350 (-3.2A)
WSA  A1350 (-2.7A)
SO4  A1363 ( 3.2A)
 0.69A 1qu2A-2yy5A:
5.8		 1qu2A-2yy5A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 12 ILE A 225
ALA A 228
MET A 249
LEU A  17
ILE A 191
 None
None
None
None
WSA  A1350 (-3.7A)
 1.35A 1y0xX-2yy5A:
undetectable		 1y0xX-2yy5A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		4 / 4 LEU A  17
PRO A 260
ILE A 300
LEU A 297
 None
 1.06A 1ya4B-2yy5A:
undetectable		 1ya4B-2yy5A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 12 PHE A  79
ALA A 323
ALA A 327
THR A 330
MET A 137
 None
None
None
None
WSA  A1350 (-3.9A)
 1.39A 2x2nD-2yy5A:
undetectable		 2x2nD-2yy5A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 12 ALA A 288
GLU A 291
LEU A 265
GLY A 270
LEU A 273
 None
 1.20A 2yjaB-2yy5A:
undetectable		 2yjaB-2yy5A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 10 ALA A 288
GLU A 291
LEU A 257
LEU A 265
LEU A 273
 None
 1.34A 3erdB-2yy5A:
undetectable		 3erdB-2yy5A:
23.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		9 / 10 GLY A   8
GLN A  10
HIS A  44
MET A 137
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-3.9A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.52A 3fhjA-2yy5A:
35.6		 3fhjA-2yy5A:
40.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		9 / 10 GLY A   8
GLN A  10
HIS A  44
MET A 137
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-3.9A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.61A 3fhjB-2yy5A:
33.8		 3fhjB-2yy5A:
40.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		9 / 10 GLY A   8
GLN A  10
HIS A  44
MET A 137
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-3.9A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.58A 3fhjC-2yy5A:
33.6		 3fhjC-2yy5A:
40.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
HIS A  44
MET A 137
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.5A)
WSA  A1350 (-3.9A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.45A 3fhjD-2yy5A:
34.4		 3fhjD-2yy5A:
40.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		9 / 10 GLY A   8
GLN A  10
HIS A  44
MET A 137
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-3.9A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.56A 3fhjE-2yy5A:
34.6		 3fhjE-2yy5A:
40.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
HIS A  44
MET A 137
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.5A)
WSA  A1350 (-3.9A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.44A 3fhjF-2yy5A:
35.8		 3fhjF-2yy5A:
40.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
GLN A  10
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.59A 3fi0A-2yy5A:
35.2		 3fi0A-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		7 / 8 GLY A   8
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.53A 3fi0B-2yy5A:
34.5		 3fi0B-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
GLN A  10
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.63A 3fi0C-2yy5A:
35.5		 3fi0C-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
GLN A  10
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.61A 3fi0D-2yy5A:
35.7		 3fi0D-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 7 GLY A   8
HIS A  44
ASP A 140
ILE A 141
VAL A 149
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
 0.35A 3fi0E-2yy5A:
33.9		 3fi0E-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 7 HIS A  44
ASP A 140
ILE A 141
VAL A 149
GLN A 155
 WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
SO4  A1363 ( 3.2A)
 0.49A 3fi0E-2yy5A:
33.9		 3fi0E-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
GLN A  10
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.69A 3fi0F-2yy5A:
34.5		 3fi0F-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		7 / 8 GLY A   8
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.45A 3fi0G-2yy5A:
35.7		 3fi0G-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
GLN A  10
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.60A 3fi0H-2yy5A:
35.2		 3fi0H-2yy5A:
40.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		7 / 8 GLY A   8
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.46A 3fi0I-2yy5A:
35.3		 3fi0I-2yy5A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
GLN A  10
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.62A 3fi0J-2yy5A:
35.7		 3fi0J-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
GLN A  10
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.64A 3fi0K-2yy5A:
34.8		 3fi0K-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
GLN A  10
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.50A 3fi0L-2yy5A:
35.6		 3fi0L-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
GLN A  10
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.62A 3fi0M-2yy5A:
35.0		 3fi0M-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
GLN A  10
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.63A 3fi0N-2yy5A:
35.6		 3fi0N-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
GLN A  10
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.56A 3fi0O-2yy5A:
35.2		 3fi0O-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		6 / 7 GLY A   8
GLN A  10
HIS A  44
ASP A 140
ILE A 141
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
SO4  A1363 ( 3.2A)
 0.70A 3fi0P-2yy5A:
34.7		 3fi0P-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		7 / 8 GLY A   8
GLN A  10
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
 0.70A 3fi0Q-2yy5A:
35.2		 3fi0Q-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
GLN A  10
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.60A 3fi0R-2yy5A:
33.8		 3fi0R-2yy5A:
40.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 12 LEU A 273
PHE A 277
ALA A 255
ILE A 191
GLY A 245
 None
None
None
WSA  A1350 (-3.7A)
None
 1.05A 3nxuA-2yy5A:
undetectable		 3nxuA-2yy5A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 12 LEU A 257
ALA A 292
THR A 293
ASN A 295
LEU A 296
 None
 0.76A 3r9cA-2yy5A:
undetectable		 3r9cA-2yy5A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		4 / 6 MET A  90
LEU A 143
PRO A 146
TYR A 144
 None
 1.44A 3vkxA-2yy5A:
undetectable		 3vkxA-2yy5A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		4 / 6 ASP A 231
GLY A 245
VAL A 246
THR A 229
 None
 0.80A 3vqrA-2yy5A:
undetectable		 3vqrA-2yy5A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		4 / 5 ASP A 231
GLY A 245
VAL A 246
THR A 229
 None
 0.81A 3vqrB-2yy5A:
undetectable		 3vqrB-2yy5A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 11 SER A  98
LEU A 331
ASP A 140
LEU A 136
GLY A 139
 None
None
WSA  A1350 (-4.1A)
None
None
 1.48A 4foxC-2yy5A:
undetectable		 4foxC-2yy5A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		4 / 8 LEU A 250
LEU A 253
LEU A 257
ILE A 236
 None
 0.88A 4klaA-2yy5A:
undetectable		 4klaA-2yy5A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUF_A_ACTA605_0
(SERUM ALBUMIN)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		4 / 4 ALA A  41
HIS A  87
PHE A  39
LEU A  80
 WSA  A1350 ( 3.8A)
None
WSA  A1350 (-4.8A)
None
 1.46A 4lufA-2yy5A:
0.0		 4lufA-2yy5A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA609_0
(SERUM ALBUMIN)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		4 / 4 ALA A  41
HIS A  87
PHE A  39
LEU A  80
 WSA  A1350 ( 3.8A)
None
WSA  A1350 (-4.8A)
None
 1.50A 4luhA-2yy5A:
0.3		 4luhA-2yy5A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		4 / 5 GLY A  18
ILE A 212
LEU A 256
LEU A  27
 WSA  A1350 (-3.5A)
None
None
None
 0.78A 4o8fA-2yy5A:
undetectable		 4o8fA-2yy5A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 11 ALA A 288
GLU A 291
LEU A 265
GLY A 270
LEU A 273
 None
 1.23A 4pxmB-2yy5A:
undetectable		 4pxmB-2yy5A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 11 ALA A 288
GLU A 291
LEU A 257
LEU A 265
LEU A 273
 None
 1.31A 4zn7B-2yy5A:
undetectable		 4zn7B-2yy5A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		3 / 3 THR A 326
THR A 329
PHE A 334
 None
 0.91A 5cxvA-2yy5A:
undetectable		 5cxvA-2yy5A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 10 ALA A 288
GLU A 291
LEU A 265
GLY A 270
LEU A 273
 None
 1.19A 5dx3A-2yy5A:
undetectable		 5dx3A-2yy5A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 10 ALA A 288
GLU A 291
LEU A 265
GLY A 270
LEU A 273
 None
 1.21A 5dxbA-2yy5A:
undetectable		 5dxbA-2yy5A:
23.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V0I_A_TRPA402_0
(TRYPTOPHAN--TRNA
LIGASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
GLN A  10
HIS A  44
MET A 137
ASP A 140
ILE A 141
VAL A 149
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-3.9A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
SO4  A1363 ( 3.2A)
 0.59A 5v0iA-2yy5A:
36.6		 5v0iA-2yy5A:
38.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V0I_B_TRPB402_0
(TRYPTOPHAN--TRNA
LIGASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
GLN A  10
HIS A  44
MET A 137
ASP A 140
ILE A 141
VAL A 149
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-3.9A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
SO4  A1363 ( 3.2A)
 0.56A 5v0iB-2yy5A:
37.3		 5v0iB-2yy5A:
38.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		4 / 5 PRO A 244
GLY A 245
THR A 247
ASN A 248
 None
 1.16A 5x23A-2yy5A:
undetectable		 5x23A-2yy5A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 10 LEU A 296
TYR A  20
LEU A  27
LEU A  67
ALA A  68
 None
 1.27A 5y7pD-2yy5A:
undetectable		 5y7pD-2yy5A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 10 LEU A  62
LEU A 316
ASP A  83
ILE A   9
GLY A   8
 None
None
None
WSA  A1350 ( 4.3A)
WSA  A1350 (-3.7A)
 1.24A 6dm0B-2yy5A:
undetectable
6dm0C-2yy5A:
undetectable		 6dm0B-2yy5A:
13.18
6dm0C-2yy5A:
13.18