SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yy6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 2yy6 PHOSPHOGLYCOLATE
PHOSPHATASE
(Aquifex
aeolicus) 		4 / 6 PHE A 124
ALA A 101
LEU A 100
ILE A   4
 None
 0.99A 1sbrA-2yy6A:
undetectable
1sbrB-2yy6A:
undetectable		 1sbrA-2yy6A:
21.93
1sbrB-2yy6A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 2yy6 PHOSPHOGLYCOLATE
PHOSPHATASE
(Aquifex
aeolicus) 		4 / 7 SER A  15
TYR A  72
ILE A  19
ASP A   9
 None
 1.07A 2x45B-2yy6A:
undetectable		 2x45B-2yy6A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 2yy6 PHOSPHOGLYCOLATE
PHOSPHATASE
(Aquifex
aeolicus) 		4 / 5 PRO A  84
ILE A  86
PRO A  87
TYR A  88
 None
 1.29A 3d9lA-2yy6A:
undetectable
3d9lY-2yy6A:
undetectable		 3d9lA-2yy6A:
20.18
3d9lY-2yy6A:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2yy6 PHOSPHOGLYCOLATE
PHOSPHATASE
(Aquifex
aeolicus) 		4 / 5 SER A 197
ASP A 162
ASP A 164
ILE A 167
 None
 1.24A 3uj7B-2yy6A:
undetectable		 3uj7B-2yy6A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2yy6 PHOSPHOGLYCOLATE
PHOSPHATASE
(Aquifex
aeolicus) 		4 / 6 THR A 163
GLY A 161
ARG A 172
ILE A 159
 None
 1.25A 4acaC-2yy6A:
3.8		 4acaC-2yy6A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2yy6 PHOSPHOGLYCOLATE
PHOSPHATASE
(Aquifex
aeolicus) 		4 / 8 LEU A  51
THR A  26
LEU A  27
LEU A  23
 None
 0.73A 4z90F-2yy6A:
undetectable
4z90G-2yy6A:
undetectable
4z90H-2yy6A:
undetectable
4z90I-2yy6A:
undetectable
4z90J-2yy6A:
undetectable		 4z90F-2yy6A:
20.86
4z90G-2yy6A:
20.86
4z90H-2yy6A:
20.86
4z90I-2yy6A:
20.86
4z90J-2yy6A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2yy6 PHOSPHOGLYCOLATE
PHOSPHATASE
(Aquifex
aeolicus) 		5 / 10 LEU A  56
THR A  26
LEU A  27
LEU A  23
LEU A  51
 None
 1.04A 4z91A-2yy6A:
undetectable
4z91B-2yy6A:
undetectable
4z91C-2yy6A:
undetectable
4z91D-2yy6A:
undetectable
4z91E-2yy6A:
undetectable		 4z91A-2yy6A:
20.86
4z91B-2yy6A:
20.86
4z91C-2yy6A:
20.86
4z91D-2yy6A:
20.86
4z91E-2yy6A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2yy6 PHOSPHOGLYCOLATE
PHOSPHATASE
(Aquifex
aeolicus) 		5 / 12 LEU A  23
VAL A  67
VAL A  48
TYR A  64
LEU A  27
 None
 1.25A 5cymA-2yy6A:
undetectable		 5cymA-2yy6A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWV_A_BEZA202_0
(ARA H 8 ALLERGEN)		 2yy6 PHOSPHOGLYCOLATE
PHOSPHATASE
(Aquifex
aeolicus) 		4 / 4 PHE A 124
ASP A 125
LEU A  90
LYS A  94
 None
 1.13A 6awvA-2yy6A:
undetectable		 6awvA-2yy6A:
25.22