SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yy7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		5 / 12 TYR A 170
GLY A  15
PHE A 114
TYR A 143
LEU A  78
 None
None
None
GOL  A1001 ( 4.1A)
None
 1.08A 1fduA-2yy7A:
16.3		 1fduA-2yy7A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		4 / 7 VAL A 165
TYR A 156
TYR A 157
TRP A 153
 None
None
None
PE8  A2002 (-4.8A)
 0.91A 1lweA-2yy7A:
undetectable		 1lweA-2yy7A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		4 / 8 VAL A 165
TYR A 156
TYR A 157
TRP A 153
 None
None
None
PE8  A2002 (-4.8A)
 1.02A 1s1xA-2yy7A:
undetectable		 1s1xA-2yy7A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		4 / 8 TYR A 267
THR A 248
TYR A 187
LEU A 300
 None
 1.47A 1uw6D-2yy7A:
undetectable
1uw6E-2yy7A:
undetectable		 1uw6D-2yy7A:
20.90
1uw6E-2yy7A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		4 / 8 TYR A 267
THR A 248
TYR A 187
LEU A 300
 None
 1.47A 1uw6P-2yy7A:
undetectable
1uw6Q-2yy7A:
undetectable		 1uw6P-2yy7A:
20.90
1uw6Q-2yy7A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		4 / 8 LEU A 300
TYR A 267
THR A 248
TYR A 187
 None
 1.48A 1uw6P-2yy7A:
undetectable
1uw6T-2yy7A:
undetectable		 1uw6P-2yy7A:
20.90
1uw6T-2yy7A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		5 / 12 LEU A 300
ALA A 253
ILE A 256
ILE A 191
ALA A 188
 None
 1.04A 2bxcA-2yy7A:
undetectable		 2bxcA-2yy7A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		4 / 6 SER A 302
PHE A 298
ASP A 299
GLU A 309
 None
 1.26A 2vn1B-2yy7A:
undetectable		 2vn1B-2yy7A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HVT_A_NVPA557_1
(HIV-1 REVERSE
TRANSCRIPTASE
(SUBUNIT P66))		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		5 / 9 VAL A 163
TYR A 156
TYR A 157
GLY A 162
TRP A 153
 None
None
None
None
PE8  A2002 (-4.8A)
 1.45A 3hvtA-2yy7A:
0.9		 3hvtA-2yy7A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		5 / 11 ILE A   5
ALA A  33
MET A  75
ILE A 220
LEU A  22
 None
None
NAD  A3001 (-4.8A)
None
None
 1.31A 3qg2B-2yy7A:
2.6		 3qg2B-2yy7A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		4 / 5 ILE A 145
PRO A 139
SER A  80
GLY A 144
 None
None
GOL  A1001 (-3.6A)
None
 1.14A 3tkdB-2yy7A:
undetectable		 3tkdB-2yy7A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		4 / 5 ILE A 145
PRO A 139
SER A  80
GLY A 144
 None
None
GOL  A1001 (-3.6A)
None
 1.13A 3tkdA-2yy7A:
undetectable		 3tkdA-2yy7A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		5 / 12 ASP A 186
ILE A 220
THR A 185
PHE A 114
ALA A  76
 None
None
GOL  A1001 (-3.2A)
None
NAD  A3001 (-3.5A)
 1.30A 3ua1A-2yy7A:
undetectable		 3ua1A-2yy7A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		5 / 12 LEU A  18
ILE A   5
TYR A  73
PHE A 114
TYR A 170
 None
 1.44A 4a79A-2yy7A:
3.1		 4a79A-2yy7A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		5 / 12 LEU A  18
ILE A   5
TYR A  73
PHE A 114
TYR A 170
 None
 1.44A 4a79B-2yy7A:
3.1		 4a79B-2yy7A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		5 / 11 LEU A  18
ILE A   5
TYR A  73
PHE A 114
TYR A 170
 None
 1.44A 4a7aA-2yy7A:
3.0		 4a7aA-2yy7A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		4 / 8 MET A 245
GLU A 251
GLU A 255
LYS A 258
 None
 1.18A 4bqfB-2yy7A:
3.7		 4bqfB-2yy7A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_B_EF2B151_1
(CEREBLON ISOFORM 4)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		4 / 7 PRO A 280
PHE A 122
TRP A 279
TYR A 143
 None
None
None
GOL  A1001 ( 4.1A)
 1.43A 4v2yB-2yy7A:
undetectable		 4v2yB-2yy7A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_A_Y70A151_1
(CEREBLON ISOFORM 4)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		4 / 7 PRO A 280
PHE A 122
TRP A 279
TYR A 143
 None
None
None
GOL  A1001 ( 4.1A)
 1.47A 4v2zA-2yy7A:
undetectable		 4v2zA-2yy7A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_B_Y70B151_1
(CEREBLON ISOFORM 4)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		4 / 8 PRO A 280
PHE A 122
TRP A 279
TYR A 143
 None
None
None
GOL  A1001 ( 4.1A)
 1.45A 4v2zB-2yy7A:
undetectable		 4v2zB-2yy7A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		4 / 8 PRO A 280
PHE A 122
TRP A 279
TYR A 143
 None
None
None
GOL  A1001 ( 4.1A)
 1.43A 5amiB-2yy7A:
undetectable		 5amiB-2yy7A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_B_EF2B151_1
(CEREBLON ISOFORM 4)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		4 / 7 PRO A 280
PHE A 122
TRP A 279
TYR A 143
 None
None
None
GOL  A1001 ( 4.1A)
 1.47A 5amjB-2yy7A:
undetectable		 5amjB-2yy7A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		4 / 8 PRO A 280
PHE A 122
TRP A 279
TYR A 143
 None
None
None
GOL  A1001 ( 4.1A)
 1.31A 5amkA-2yy7A:
undetectable		 5amkA-2yy7A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		5 / 7 ALA A 120
GLU A  84
GLY A 144
SER A 140
GLY A 123
 GOL  A1001 ( 4.9A)
None
None
None
None
 1.38A 5e26A-2yy7A:
undetectable
5e26B-2yy7A:
undetectable		 5e26A-2yy7A:
20.91
5e26B-2yy7A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_B_EF2B202_0
(CEREBLON ISOFORM 4)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		4 / 7 PRO A 280
PHE A 122
TRP A 279
TYR A 143
 None
None
None
GOL  A1001 ( 4.1A)
 1.49A 5oh1B-2yy7A:
undetectable		 5oh1B-2yy7A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH3_B_9V2B202_0
(CEREBLON ISOFORM 4)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		4 / 7 PRO A 280
PHE A 122
TRP A 279
TYR A 143
 None
None
None
GOL  A1001 ( 4.1A)
 1.44A 5oh3B-2yy7A:
undetectable		 5oh3B-2yy7A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		5 / 12 ASP A 186
ILE A 220
THR A 185
PHE A 114
ALA A  76
 None
None
GOL  A1001 (-3.2A)
None
NAD  A3001 (-3.5A)
 1.29A 5vcgA-2yy7A:
undetectable		 5vcgA-2yy7A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		5 / 12 GLU A 155
GLN A 287
PRO A 139
ILE A 136
PHE A 122
 None
 1.21A 6becA-2yy7A:
undetectable
6becB-2yy7A:
undetectable
6becC-2yy7A:
undetectable		 6becA-2yy7A:
20.14
6becB-2yy7A:
20.14
6becC-2yy7A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 2yy7 L-THREONINE
DEHYDROGENASE
(Flavobacterium
frigidimaris) 		4 / 5 GLY A 172
LEU A 173
SER A 118
TYR A 143
 NAD  A3001 ( 3.9A)
NAD  A3001 (-3.7A)
GOL  A1001 ( 2.8A)
GOL  A1001 ( 4.1A)
 1.30A 6ji6A-2yy7A:
undetectable		 6ji6A-2yy7A:
20.69