SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yy8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1I7Q_A_BEZA1501_0 (ANTHRANILATE SYNTHASE)	2yy8	UPF0106 PROTEIN PH0461 (Pyrococcus horikoshii)	5 / 11	ILE A 33 THR A 18 GLU A 134 LEU A 5 GLY A 109	None None MTA A 400 (-4.0A) None MTA A 400 (-3.3A)	1.30A	1i7qA-2yy8A: undetectable	1i7qA-2yy8A: 16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L7X_B_CFFB1863_1 (GLYCOGEN PHOSPHORYLASE, LIVER FORM)	2yy8	UPF0106 PROTEIN PH0461 (Pyrococcus horikoshii)	4 / 6	ASN A 129 HIS A 132 ALA A 126 GLY A 84	None MTA A 400 (-3.7A) MTA A 400 (-4.3A) None	1.14A	1l7xB-2yy8A: undetectable	1l7xB-2yy8A: 12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JN3_A_JN3A130_1 (FATTY ACID-BINDING PROTEIN, LIVER)	2yy8	UPF0106 PROTEIN PH0461 (Pyrococcus horikoshii)	5 / 12	LEU A 138 ALA A 30 ILE A 2 ILE A 127 LEU A 80	None None None MTA A 400 (-4.3A) MTA A 400 (-4.2A)	1.13A	2jn3A-2yy8A: undetectable	2jn3A-2yy8A: 19.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2YY8_B_SAMB500_0 (UPF0106 PROTEIN PH0461)	2yy8	UPF0106 PROTEIN PH0461 (Pyrococcus horikoshii)	10 / 11	LEU A 80 MET A 82 VAL A 108 GLY A 109 LYS A 112 VAL A 113 ILE A 127 HIS A 132 GLU A 134 ALA A 137	MTA A 400 (-4.2A) MTA A 400 (-4.9A) MTA A 400 ( 3.7A) MTA A 400 (-3.3A) None None MTA A 400 (-4.3A) MTA A 400 (-3.7A) MTA A 400 (-4.0A) MTA A 400 (-3.5A)	0.38A	2yy8A-2yy8A: 34.4 2yy8B-2yy8A: 31.9	2yy8A-2yy8A: 100.00 2yy8B-2yy8A: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LMN_A_EUIA503_1 (DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1)	2yy8	UPF0106 PROTEIN PH0461 (Pyrococcus horikoshii)	5 / 12	LEU A 141 LEU A 138 ILE A 106 GLY A 29 LEU A 145	None	1.04A	4lmnA-2yy8A: undetectable	4lmnA-2yy8A: 21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OF1_A_SALA301_1 (SPORE COAT-ASSOCIATED PROTEIN N)	2yy8	UPF0106 PROTEIN PH0461 (Pyrococcus horikoshii)	4 / 5	ALA A 25 VAL A 21 PHE A 58 ILE A 35	None	1.01A	5of1A-2yy8A: undetectable	5of1A-2yy8A: 16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	2yy8	UPF0106 PROTEIN PH0461 (Pyrococcus horikoshii)	4 / 8	ILE A 34 THR A 18 VAL A 17 GLU A 134	None None None MTA A 400 (-4.0A)	0.95A	6fbvC-2yy8A: undetectable	6fbvC-2yy8A: 10.55

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1I7Q_A_BEZA1501_0","ANTHRANILATE SYNTHASE","2yy8","UPF0106 PROTEIN PH0461","Pyrococcus horikoshii",5,"ILE A  33;THR A  18;GLU A 134;LEU A   5;GLY A 109","None;None;MTA A 400 (-4.0A);None;MTA A 400 (-3.3A)","1.30A","1i7qA-2yy8A:undetectable","1i7qA-2yy8A:16.47"],["1L7X_B_CFFB1863_1","GLYCOGEN PHOSPHORYLASE, LIVER FORM","2yy8","UPF0106 PROTEIN PH0461","Pyrococcus horikoshii",4,"ASN A 129;HIS A 132;ALA A 126;GLY A  84","None;MTA A 400 (-3.7A);MTA A 400 (-4.3A);None","1.14A","1l7xB-2yy8A:undetectable","1l7xB-2yy8A:12.28"],["2JN3_A_JN3A130_1","FATTY ACID-BINDING PROTEIN, LIVER","2yy8","UPF0106 PROTEIN PH0461","Pyrococcus horikoshii",5,"LEU A 138;ALA A  30;ILE A   2;ILE A 127;LEU A  80","None;None;None;MTA A 400 (-4.3A);MTA A 400 (-4.2A)","1.13A","2jn3A-2yy8A:undetectable","2jn3A-2yy8A:19.21"],["2YY8_B_SAMB500_0","UPF0106 PROTEIN PH0461","2yy8","UPF0106 PROTEIN PH0461","Pyrococcus horikoshii",10,"LEU A  80;MET A  82;VAL A 108;GLY A 109;LYS A 112;VAL A 113;ILE A 127;HIS A 132;GLU A 134;ALA A 137","MTA A 400 (-4.2A);MTA A 400 (-4.9A);MTA A 400 ( 3.7A);MTA A 400 (-3.3A);None;None;MTA A 400 (-4.3A);MTA A 400 (-3.7A);MTA A 400 (-4.0A);MTA A 400 (-3.5A)","0.38A","2yy8A-2yy8A:34.4;2yy8B-2yy8A:31.9","2yy8A-2yy8A:100.00;2yy8B-2yy8A:100.00"],["4LMN_A_EUIA503_1","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1","2yy8","UPF0106 PROTEIN PH0461","Pyrococcus horikoshii",5,"LEU A 141;LEU A 138;ILE A 106;GLY A  29;LEU A 145","None","1.04A","4lmnA-2yy8A:undetectable","4lmnA-2yy8A:21.79"],["5OF1_A_SALA301_1","SPORE COAT-ASSOCIATED PROTEIN N","2yy8","UPF0106 PROTEIN PH0461","Pyrococcus horikoshii",4,"ALA A  25;VAL A  21;PHE A  58;ILE A  35","None","1.01A","5of1A-2yy8A:undetectable","5of1A-2yy8A:16.00"],["6FBV_D_FI8D1904_0","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA;DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA'","2yy8","UPF0106 PROTEIN PH0461","Pyrococcus horikoshii",4,"ILE A  34;THR A  18;VAL A  17;GLU A 134","None;None;None;MTA A 400 (-4.0A)","0.95A","6fbvC-2yy8A:undetectable","6fbvC-2yy8A:10.55"]]