SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yyb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 2yyb HYPOTHETICAL PROTEIN
TTHA1606
(Thermus
thermophilus) 		3 / 3 VAL A 180
VAL A 166
TRP A 124
 None
 0.97A 1av2C-2yybA:
undetectable
1av2D-2yybA:
undetectable		 1av2C-2yybA:
5.61
1av2D-2yybA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 2yyb HYPOTHETICAL PROTEIN
TTHA1606
(Thermus
thermophilus) 		4 / 8 ASP A 101
HIS A  64
HIS A  65
HIS A  97
 None
 0.95A 1ei6D-2yybA:
undetectable		 1ei6D-2yybA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2yyb HYPOTHETICAL PROTEIN
TTHA1606
(Thermus
thermophilus) 		4 / 5 ASP A 101
ASP A 125
LEU A 176
LEU A  98
 None
 1.14A 1nh8A-2yybA:
undetectable		 1nh8A-2yybA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2yyb HYPOTHETICAL PROTEIN
TTHA1606
(Thermus
thermophilus) 		3 / 3 GLU A 214
HIS A  65
HIS A 210
 None
 0.71A 1oe2A-2yybA:
undetectable		 1oe2A-2yybA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 2yyb HYPOTHETICAL PROTEIN
TTHA1606
(Thermus
thermophilus) 		4 / 4 HIS A  64
GLU A 214
HIS A  65
HIS A  97
 None
 1.28A 1uttA-2yybA:
undetectable		 1uttA-2yybA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 2yyb HYPOTHETICAL PROTEIN
TTHA1606
(Thermus
thermophilus) 		3 / 3 VAL A 180
VAL A 166
TRP A 124
 None
 0.97A 1w5uC-2yybA:
undetectable
1w5uD-2yybA:
undetectable		 1w5uC-2yybA:
5.61
1w5uD-2yybA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 2yyb HYPOTHETICAL PROTEIN
TTHA1606
(Thermus
thermophilus) 		5 / 12 ALA A  45
LEU A  61
ILE A  62
LEU A  28
LEU A  86
 None
 0.90A 1xdkF-2yybA:
undetectable		 1xdkF-2yybA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 2yyb HYPOTHETICAL PROTEIN
TTHA1606
(Thermus
thermophilus) 		3 / 3 ARG A 144
ASP A 183
ASP A 181
 None
 0.80A 2ejtA-2yybA:
undetectable		 2ejtA-2yybA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 2yyb HYPOTHETICAL PROTEIN
TTHA1606
(Thermus
thermophilus) 		5 / 11 ARG A  82
LEU A  28
ALA A  95
GLU A  47
LEU A  61
 None
 1.31A 2v0mD-2yybA:
undetectable		 2v0mD-2yybA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2yyb HYPOTHETICAL PROTEIN
TTHA1606
(Thermus
thermophilus) 		5 / 12 HIS A 210
HIS A  64
THR A 187
VAL A 169
LEU A 176
 None
 1.49A 2xrlA-2yybA:
undetectable		 2xrlA-2yybA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yyb HYPOTHETICAL PROTEIN
TTHA1606
(Thermus
thermophilus) 		3 / 3 HIS A  97
HIS A  65
HIS A  64
 None
 0.74A 3ag4A-2yybA:
undetectable		 3ag4A-2yybA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 2yyb HYPOTHETICAL PROTEIN
TTHA1606
(Thermus
thermophilus) 		3 / 3 ARG A   3
ASP A  11
ASP A   4
 None
 0.87A 3jayA-2yybA:
undetectable		 3jayA-2yybA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 2yyb HYPOTHETICAL PROTEIN
TTHA1606
(Thermus
thermophilus) 		4 / 8 ARG A 201
VAL A 194
LEU A 177
PRO A 178
 None
 1.11A 3jq7C-2yybA:
undetectable		 3jq7C-2yybA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 2yyb HYPOTHETICAL PROTEIN
TTHA1606
(Thermus
thermophilus) 		3 / 3 HIS A  64
HIS A  97
HIS A  65
 None
 0.86A 3mihA-2yybA:
undetectable		 3mihA-2yybA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 2yyb HYPOTHETICAL PROTEIN
TTHA1606
(Thermus
thermophilus) 		3 / 3 HIS A  97
HIS A  65
HIS A  64
 None
 0.73A 3mihA-2yybA:
undetectable		 3mihA-2yybA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 2yyb HYPOTHETICAL PROTEIN
TTHA1606
(Thermus
thermophilus) 		4 / 5 LEU A  98
HIS A  65
GLU A 214
HIS A 210
 None
 1.38A 4a7bB-2yybA:
undetectable		 4a7bB-2yybA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2yyb HYPOTHETICAL PROTEIN
TTHA1606
(Thermus
thermophilus) 		5 / 12 VAL A 163
ASP A 183
THR A 213
GLY A 130
LEU A 168
 None
 1.49A 5m50B-2yybA:
undetectable		 5m50B-2yybA:
22.07