SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yyh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 2yyh 8-OXO-DGTPASE DOMAIN
(Aquifex
aeolicus) 		4 / 5 ASP A  13
SER A  90
GLY A  44
ARG A  85
 None
 1.14A 2j2pA-2yyhA:
undetectable
2j2pB-2yyhA:
undetectable		 2j2pA-2yyhA:
19.16
2j2pB-2yyhA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 2yyh 8-OXO-DGTPASE DOMAIN
(Aquifex
aeolicus) 		5 / 9 ALA A  97
VAL A  28
GLY A  65
VAL A  14
ILE A  16
 None
 1.19A 4ll3B-2yyhA:
undetectable		 4ll3B-2yyhA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yyh 8-OXO-DGTPASE DOMAIN
(Aquifex
aeolicus) 		4 / 5 THR A  64
GLU A  59
THR A  12
LEU A  70
 None
 1.07A 5hm8G-2yyhA:
undetectable		 5hm8G-2yyhA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2yyh 8-OXO-DGTPASE DOMAIN
(Aquifex
aeolicus) 		4 / 5 ILE A  94
LYS A 129
ILE A 131
HIS A 127
 None
 0.98A 5jmnA-2yyhA:
undetectable		 5jmnA-2yyhA:
9.38