SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yyo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 2yyo SPRY
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens) 		4 / 8 THR A 126
ASP A 105
GLY A 133
TYR A  80
 None
 1.03A 1bu5B-2yyoA:
undetectable		 1bu5B-2yyoA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2yyo SPRY
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens) 		4 / 7 VAL A  58
TYR A  80
GLY A  59
TYR A  42
 None
 0.92A 1lweA-2yyoA:
undetectable		 1lweA-2yyoA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 2yyo SPRY
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens) 		3 / 3 GLY A 143
ASP A 142
SER A 140
 None
 0.74A 2qhfA-2yyoA:
undetectable		 2qhfA-2yyoA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 2yyo SPRY
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens) 		4 / 7 LEU A  60
LEU A  36
PRO A 113
ILE A 111
 None
 0.83A 3s56B-2yyoA:
undetectable		 3s56B-2yyoA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 2yyo SPRY
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens) 		5 / 12 TYR A  65
GLY A  59
ALA A 147
ILE A 123
VAL A  78
 None
 1.30A 4azsA-2yyoA:
undetectable		 4azsA-2yyoA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2yyo SPRY
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens) 		4 / 8 VAL A  58
VAL A  78
TYR A  80
TYR A  42
 None
 1.05A 4puoC-2yyoA:
undetectable		 4puoC-2yyoA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2yyo SPRY
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens) 		4 / 6 ARG A  53
ASP A  83
LYS A  86
HIS A  81
 None
 1.41A 5a06A-2yyoA:
undetectable		 5a06A-2yyoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2yyo SPRY
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens) 		3 / 3 LEU A 161
TYR A  30
SER A  33
 None
 0.82A 5iktA-2yyoA:
undetectable		 5iktA-2yyoA:
15.56