SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yys'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 9 LEU A  81
LEU A  69
VAL A  10
GLY A  11
LEU A  15
 None
 1.19A 1e7aB-2yysA:
undetectable		 1e7aB-2yysA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		4 / 6 LEU A 284
LEU A 276
LEU A 113
LEU A 110
 None
GOL  A 501 ( 3.6A)
None
None
 0.93A 1errA-2yysA:
undetectable		 1errA-2yysA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 12 VAL A  78
ASP A  79
LEU A 243
LEU A 214
THR A 215
 None
 0.98A 1jffB-2yysA:
undetectable		 1jffB-2yysA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_0
(PROTEIN (METHIONINE
REPRESSOR))		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 9 GLU A 111
ARG A 114
ARG A 115
GLU A  83
ALA A  80
 None
 1.43A 1mj2C-2yysA:
undetectable		 1mj2C-2yysA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 9 GLU A 111
ARG A 114
ARG A 115
GLU A  83
ALA A  80
 None
 1.45A 1mjoA-2yysA:
undetectable		 1mjoA-2yysA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 9 GLU A 111
ARG A 114
ARG A 115
GLU A  83
ALA A  80
 None
 1.42A 1mjoB-2yysA:
undetectable		 1mjoB-2yysA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 9 GLU A 111
ARG A 114
ARG A 115
GLU A  83
ALA A  80
 None
 1.44A 1mjoC-2yysA:
undetectable		 1mjoC-2yysA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 12 TYR A 210
LEU A 208
ASP A  79
VAL A  82
ALA A 101
 None
 1.29A 2g70A-2yysA:
undetectable		 2g70A-2yysA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 12 TYR A 210
LEU A 208
ASP A  79
VAL A  82
ALA A 101
 None
 1.32A 2g72A-2yysA:
2.0		 2g72A-2yysA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 12 VAL A  78
ASP A  79
LEU A 243
LEU A 214
THR A 215
 None
 0.98A 2hxfB-2yysA:
undetectable		 2hxfB-2yysA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 12 VAL A  78
ASP A  79
LEU A 243
LEU A 214
THR A 215
 None
 0.98A 2hxhB-2yysA:
undetectable		 2hxhB-2yysA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 12 VAL A  78
ASP A  79
LEU A 243
LEU A 214
THR A 215
 None
 0.98A 2p4nB-2yysA:
undetectable		 2p4nB-2yysA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		4 / 7 TRP A 258
TYR A  40
TYR A 256
ILE A 259
 None
 1.08A 2ph9A-2yysA:
undetectable
2ph9B-2yysA:
undetectable		 2ph9A-2yysA:
17.63
2ph9B-2yysA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		3 / 3 LEU A  69
PRO A  70
LEU A  75
 None
 0.60A 2po5B-2yysA:
3.1		 2po5B-2yysA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		3 / 3 LEU A  69
PRO A  70
LEU A  75
 None
 0.56A 2po7B-2yysA:
3.0		 2po7B-2yysA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		3 / 3 LEU A  69
PRO A  70
LEU A  75
 None
 0.29A 2qd5B-2yysA:
1.9		 2qd5B-2yysA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 12 VAL A  78
ASP A  79
LEU A 243
LEU A 214
THR A 215
 None
 0.98A 2wbeB-2yysA:
undetectable		 2wbeB-2yysA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 11 ILE A 259
GLY A 177
TYR A 181
PHE A 172
GLY A 254
 None
 1.31A 2y7kA-2yysA:
undetectable		 2y7kA-2yysA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 12 VAL A  78
ASP A  79
LEU A 243
LEU A 214
THR A 215
 None
 0.98A 3dcoB-2yysA:
undetectable		 3dcoB-2yysA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 12 VAL A  78
ASP A  79
LEU A 243
LEU A 214
THR A 215
 None
 0.98A 3edlB-2yysA:
undetectable		 3edlB-2yysA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		3 / 3 LEU A  69
PRO A  70
LEU A  75
 None
 0.54A 3hcrA-2yysA:
3.2		 3hcrA-2yysA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 12 VAL A  78
ASP A  79
LEU A 243
LEU A 214
THR A 215
 None
 0.96A 3iz0B-2yysA:
1.0		 3iz0B-2yysA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 197
GLY A  37
SER A  63
ARG A  61
ASP A  84
 None
 0.97A 3keeC-2yysA:
undetectable		 3keeC-2yysA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_B_PNNB5002_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		4 / 5 ASN A 153
ALA A 139
ALA A 136
ARG A 137
 None
 1.43A 3kp2B-2yysA:
undetectable		 3kp2B-2yysA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		4 / 8 ARG A 169
LEU A 158
ALA A 139
ALA A 142
 None
 1.01A 3ns1L-2yysA:
undetectable		 3ns1L-2yysA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 12 GLU A  12
ALA A  13
GLY A  62
ASP A  59
LEU A  15
 None
 1.23A 3ou6C-2yysA:
undetectable		 3ou6C-2yysA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 12 GLU A  12
ALA A  13
GLY A  62
ASP A  59
LEU A  15
 None
 1.23A 3ou6D-2yysA:
2.2		 3ou6D-2yysA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		4 / 6 LEU A 243
LEU A 221
LEU A 224
PRO A 127
 None
 1.10A 3q1eA-2yysA:
undetectable
3q1eC-2yysA:
undetectable		 3q1eA-2yysA:
14.49
3q1eC-2yysA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		3 / 3 LEU A  69
PRO A  70
LEU A  75
 None
 0.43A 3w1wB-2yysA:
3.2		 3w1wB-2yysA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA502_1
(CHITINASE)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		4 / 5 TRP A 258
GLY A 103
ALA A 126
PHE A 269
 None
 1.00A 3wqwA-2yysA:
undetectable		 3wqwA-2yysA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		3 / 3 ARG A 115
PHE A 116
PRO A 117
 None
 0.86A 3zoaB-2yysA:
undetectable		 3zoaB-2yysA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		6 / 12 GLY A  62
GLY A  64
GLY A  37
SER A  66
LEU A  67
ALA A  13
 None
 1.44A 4uciA-2yysA:
undetectable		 4uciA-2yysA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		6 / 12 GLY A  62
GLY A  64
GLY A  37
SER A  66
LEU A  67
ALA A  13
 None
 1.43A 4uciB-2yysA:
undetectable		 4uciB-2yysA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		6 / 12 GLY A  62
GLY A  64
GLY A  37
SER A  66
LEU A  67
ALA A  13
 None
 1.42A 4uckA-2yysA:
undetectable		 4uckA-2yysA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A  62
GLU A  14
ASP A  19
VAL A  56
ASP A  84
 None
 1.02A 5ehiC-2yysA:
undetectable		 5ehiC-2yysA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A  62
GLU A  14
ASP A  19
VAL A  56
ASP A  84
 None
 0.98A 5eiwA-2yysA:
undetectable		 5eiwA-2yysA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A  88
PHE A  58
GLU A  18
VAL A  17
GLY A  52
 None
None
None
GOL  A 502 ( 4.8A)
None
 1.25A 5f9zB-2yysA:
2.5		 5f9zB-2yysA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 12 VAL A 277
PRO A 278
ALA A 275
PHE A 269
ILE A 123
 None
 1.44A 5hgcA-2yysA:
undetectable		 5hgcA-2yysA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 12 VAL A  78
ASP A  79
LEU A 243
LEU A 214
THR A 215
 None
 0.86A 5hnwB-2yysA:
undetectable		 5hnwB-2yysA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 12 VAL A  78
ASP A  79
LEU A 243
LEU A 214
THR A 215
 None
 0.92A 5hnyB-2yysA:
undetectable		 5hnyB-2yysA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A  88
LEU A 113
PHE A  97
LEU A 124
LEU A 221
 None
 1.29A 5tiwA-2yysA:
undetectable		 5tiwA-2yysA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A  62
GLU A  14
ASP A  19
VAL A  56
ASP A  84
 None
 1.00A 5wz1C-2yysA:
undetectable		 5wz1C-2yysA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A  62
GLU A  14
ASP A  19
VAL A  56
ASP A  84
 None
 0.99A 5wz1D-2yysA:
undetectable		 5wz1D-2yysA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A  62
GLU A  14
ASP A  19
VAL A  56
ASP A  84
 None
 1.00A 5wz1E-2yysA:
undetectable		 5wz1E-2yysA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A  62
GLU A  14
ASP A  19
VAL A  56
ASP A  84
 None
 0.99A 5wz1F-2yysA:
undetectable		 5wz1F-2yysA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A  62
GLU A  14
ASP A  19
VAL A  56
ASP A  84
 None
 1.00A 5wz1G-2yysA:
undetectable		 5wz1G-2yysA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A  62
GLU A  14
ASP A  19
VAL A  56
ASP A  84
 None
 0.97A 5wz1H-2yysA:
undetectable		 5wz1H-2yysA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		5 / 7 GLY A 103
GLY A  34
PRO A  35
GLY A  36
GLY A  37
 None
GOL  A 500 (-3.9A)
None
None
None
 0.98A 6ag0A-2yysA:
undetectable		 6ag0A-2yysA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		3 / 3 GLU A 156
ASP A 149
PRO A 148
 None
 0.78A 6berA-2yysA:
undetectable		 6berA-2yysA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN
(Thermus
thermophilus) 		4 / 5 ARG A  65
GLY A  64
ASN A  38
ASP A  59
 None
 1.35A 6dwjB-2yysA:
undetectable
6dwjD-2yysA:
undetectable		 6dwjB-2yysA:
19.93
6dwjD-2yysA:
19.93